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Frontiers in epigenetic chemical biology

Discussion meeting

Location

The Royal Society, London, 6-9 Carlton House Terrace, London, SW1Y 5AG

Overview

Scientific discussion meeting organised by Professor A Ganesan, Professor Marianne Rots, Dr Paola Arimondo and Dr Akane Kawamura.

Nucleosome

Epigenetics refers to the control mechanisms that determine which genes are turned on or off in eukaryotic organisms. Epigenetics is fundamental to normal development and an organism’s response to the environment while its dysregulation is linked to disease conditions. This interdisciplinary meeting will bring together chemists and biologists that are internationally leading in cutting edge areas of epigenetics.

The schedule of talks and speaker biographies are available below. Recorded audio of the presentations will be available on this page after the meeting has taken place. Meeting papers will be published in a future issue of Philosophical Transactions B.

Call for posters - deadline Wednesday 5 April

There will be a poster session at 17.00 on Monday 22 May 2017. If you would like to apply to present a poster please submit your proposed title, abstract (not more than 200 words and in the third person), name of the proposed presenter and institution to the Scientific Programmes team no later than Wednesday 5 April. Please include the text 'Poster abstract submission' and the meeting name in the subject line. Please note that places are limited and posters are selected at the scientific organisers' discretion. Poster abstracts will only be considered if the proposed presenter is registered to attend the meeting.

Attending this event

This meeting is intended for researchers in relevant fields.

  • Free to attend
  • Limited places, advanced registration is essential
  • An optional lunch can be purchased during registration

This meeting will be followed by a related satellite meeting 'Readers, writers and erasers' to be held at the Royal Society at Chicheley Hall on 24 - 25 May 2017.

Enquiries: Contact the Scientific Programmes team

Event organisers

Select an organiser for more information

Schedule of talks

22 May

09:00-12:30

Session 1: Epigenetic modulation by small molecules

4 talks Show detail Hide detail

Chairs

Dr María Berdasco Menéndez, Bellvitge Institute for Biomedical Research, Spain

09:05-09:30 From antibiotics to histone deacetylase inhibitors: elucidating and exploiting biosynthetic protein-protein interactions

Professor Gregory Challis, University of Warwich, UK; Monash University, Australia

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09:30-09:45 Discussion

09:45-10:15 HDAC inhibitors, progress and prospects

Professor A. Ganesan, University of East Anglia, UK

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10:15-10:30 Discussion

10:30-11:00 Coffee

11:00-11:30 Regulation of cancer epigenetics by synthetic inhibitors and endogenous metabolites

Professor Minoru Yoshida, RIKEN, Japan

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11:30-11:45 Discussion

11:45-12:15 Regulation of protein biosynthesis by oxygen

Professor Christopher Schofield FRS, University of Oxford, UK

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12:15-12:30 Discussion

12:30-13:30

Lunch

13:30-17:00

Session 2: Nucleic acids beyond AGTC

4 talks Show detail Hide detail

Chairs

Professor Marianne Rots, University Medical Center Groningen, The Netherlands

13:30-14:00 Design and activity of DNA methylation inhibitors in cancer cells

Dr Paola B. Arimondo, CNRS ETaC, France

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14:00-14:15 Discussion

14:15-14:45 Identification and characterisation of methylated deoxyadenosines in vertebrates

Dr Magdalena Koziol, University of Cambridge, UK

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14:45-15:00 Discussion

15:00-15:30 Tea

15:30-16:00 Deregulation of non coding RNA in cancer and their interactions with histone modifiers

Dr María Berdasco Menéndez, Bellvitge Institute for Biomedical Research, Spain

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16:00-16:15 Discussion

16:15-16:45 New bases beyond Watson and Crick

Professor Thomas Carell, Ludwig Maximilians Universität München, Germany

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16:45-17:00 Discussion

17:00-18:15

Poster session

23 May

09:00-12:30

Session 3: Epigenetic DNA and RNA targeting

4 talks Show detail Hide detail

Chairs

Dr Akane Kawamura, University of Oxford, UK

09:00-09:30 Epigenetic approaches to overcome cancer drug resistance: a moving target

Professor Robert Brown, Imperial College London, UK

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09:30-09:45 Discussion

09:45-10:15 Rewriting a gene's epigenetic signal at will

Professor Marianne Rots, University Medical Center Groningen, The Netherlands

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10:15-10:30 Discussion

10:30-11:00 Coffee

11:00-11:30 Expanding the programmability of DNA recognition

Professor Daniel Summerer, Technical University Dortmund, Germany

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11:30-11:45 Discussion

11:45-12:15 Talk title TBC

Sir Shankar Balasubramanian FMedSci FRS, University of Cambridge, UK

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12:15-12:30 Discussion

12:30-13:30

Lunch

13:30-17:00

Session 4: Epigenetic drug discovery

4 talks Show detail Hide detail

Chairs

Professor A. Ganesan, University of East Anglia, UK

13:30-14:00 Tazemetostat, a first-in-class inhibitor of EZH2: from bench to bedside to bench

Professor Robert A. Copeland, Epizyme, Inc, USA

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14:00-14:15 Discussion

14:15-14:30 Shifting the balance: epigenetic modulators in drug development

Dr Tamara Maes, Oryzon Genomics S.A., Spain

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14:45-15:00 Discussion

15:00-15:30 Tea

15:30-16:00 Selectivity: design and serendipity for epigenetic targets

Dr Chun-wa Chung, GlaxoSmithKline, UK

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16:00-16:15 Discussion

16:15-16:45 Novel epigenetic biomarker and its clinical utility in diagnostic of Alzheimer’s disease

Dr Victoria Lunyak, Aelan Cell Technologies, USA

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16:45-17:00 Discussion

Event downloads

Related events

Frontiers in epigenetic chemical biology The Royal Society, London 6-9 Carlton House Terrace London SW1Y 5AG UK