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Meeting the challenges of modelling neurodegenerative disease in mice

Scientific meeting

Location

Kavli Royal Society Centre, Chicheley Hall, Newport Pagnell, Buckinghamshire, MK16 9JJ

Overview

Theo Murphy international scientific meeting organised by Professor Elizabeth Fisher, Professor Giampietro Schiavo and Dr Pietro Fratta

Neuromuscular junction and vascular plexus. Copyright James Sleigh, UCL Institute of Neurology

New technologies for engineering the mouse genome are increasingly sophisticated. However, mouse models of neurodegeneration try to recapitulate human late-onset disorders in an animal that lives for two years and has important differences in physiology and biochemistry. How can we best model neurodegeneration? What features matter? What has given us most insight? What is the future we would like?

The schedule of talks and speaker biographies will shortly be available below. A draft programme is available to download.

Recorded audio of the presentations will be available on this page after the meeting has taken place.

Attending this event

  • Free to attend
  • Advanced registration essential (please request an invite)
  • Catering and accommodation available to purchase during registration

Enquires: Contact the Scientific Programmes team

Event organisers

Select an organiser for more information

Schedule of talks

26 June

09:00-13:00

Using new technologies to model key questions in neurodegeneration

7 talks Show detail Hide detail

Chairs

Professor Giampietro Schiavo, UCL Institue of Neurology, UK

09:10-09:40 Genomic humanisation and other technologies in mouse

Professor Allan Bradley FRS, The Wellcome Trust Sanger Institute, UK

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09:40-10:10 Viral models in neurodegeneration

Professor Elizabeth M. Simpson, Centre for Molecular Medicine and Therapeutics (CMMT), University of British Columbia, Canada

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10:10-10:40 CRISPR Genome-wide pooled screening approaches for studying protein quality control pathways and neurodegeneration

Dr Ophir Shalem, University of Pennsylvania and Children's Hospital of Philadelphia, USA

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10:40-11:20 Coffee

11:20-11:50 Transgenics or knockins? The hare or the tortoise?

Professor Takaomi Saido , RIKEN Brain Science Institute, Japan

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11:50-12:20 Working with complex mouse models to understand neurodegenerative disease

Dr Frances Wiseman, UCL Institute of Neurology, UK

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12:20-12:50 Phenotype-driven approaches and manipulating genetic background to produce valid disease models

Dr Robert W. Burgess, The Jackson Laboratory, Bar Harbor, Maine, USA

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12:50-13:00 Discussion: Tissue specificity, site of onset, time of onset, gain or loss of function

Professor Giampietro Schiavo, UCL Institue of Neurology, UK

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13:00-14:00

Lunch

14:00-17:00

Understanding and exploiting? – differences in mouse and human

6 talks Show detail Hide detail

Chairs

Dr Pietro Fratta, UCL Institute of Neurology, UK

14:00-14:30 Mouse physiology in modelling neurodegenerative disorders

Professor Linda Greensmith , UCL Institute of Neurology, UK

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14:30-15:00 Understanding neuropathology in neurodegeneration models aligning human and mouse

Professor Maria Grazia Spillantini, University of Cambridge, UK

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15:00-15:40 Tea

15:40-16:10 Mapping and manipulating neural circuits in vivo, possible applications in neurodegeneration models

Dr Marco Tripodi, MRC Laboratory of Molecular Biology, Cambridge, UK

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16:10-16:40 Neuroimaging of mouse models

Professor Mark Lythgoe , UCL Centre for Advanced Biomedical Imaging, UK

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16:40-17:00 Discussion: Differences in mouse versus humans, are we simply modelling mouse neurodegeneration?

Dr Pietro Fratta, UCL Institute of Neurology, UK

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27 June

09:00-12:30

What do we want from disease models?

6 talks Show detail Hide detail

Chairs

Professor Elizabeth Fisher, UCL Institute of Neurology, UK

09:15-09:45 Molecular mechanisms of neurodegeneration – insights from cellular and in vitro models

Dr Dorothee Dormann, Ludwig-Maximilians-University Munich, Germany

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09:45-10:15 Better modelling of human disease progression in mouse models - rationale and insights to be gained

Professor Karen Duff, Columbia University Medical Center, New York, USA

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10:15-10:45 Insights from mouse models of Huntington’s disease

Professor Gillian Bates, UCL Institute of Neurology, UK

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10:45-11:15 Coffee

11:15-11:45 Mouse modelling of human behavioural changes in neurodegeneration

Professor David Bannerman, University of Oxford, UK

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11:45-12:15 Aligning mouse and human behaviours in neurodegeneration

Professor Mark Good, Cardiff University, UK

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12:15-12:30 Discussion: Transgenics or knock ins? Mouse paradigms or translating into human studies?

Professor Elizabeth Fisher, UCL Institute of Neurology, UK

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12:30-13:30

Lunch

13:30-17:00

Optimising future research

6 talks Show detail Hide detail

Chairs

Dr Pietro Fratta, UCL Institute of Neurology, UK

13:30-14:00 The mouse toolbox we need for neurodegeneration - lessons from prion diseases

Professor John Collinge FRS, UCL Institute of Neurology, UK

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14:00-14:30 What biopharma needs, what we do right and what we do wrong?

Dr Eric Karran, Foundational Neuroscience Center, Cambridge, Massachusetts, USA

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14:30-15:00 Tea

15:00-15:30 Aiming for validity and reproducibility in mouse models of neurodegenerative disease

Professor Monica Justice, SickKids, Toronto, Canada

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15:30-16:00 How we get to mechanism?

Professor Susan Ackerman, University of California, USA

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16:00-16:30 Mouse human chimeric models to study Alzheimers Disease

Professor Bart De Strooper, UK Dementia Research Institute, University College London, VIB and KU Leuven Belgium

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16:30-17:00 Discussion: Differences in mouse versus humans, are we simply modelling mouse neurodegeneration?

Professor Giampietro Schiavo, UCL Institue of Neurology, UK
Professor Elizabeth Fisher, UCL Institute of Neurology, UK
Dr Pietro Fratta, UCL Institute of Neurology, UK

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Meeting the challenges of modelling neurodegenerative disease in mice Kavli Royal Society Centre, Chicheley Hall Newport Pagnell Buckinghamshire MK16 9JJ