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Macropinocytosis in physiology, disease and therapy

Scientific meeting

Location

Kavli Royal Society Centre, Chicheley Hall, Newport Pagnell, Buckinghamshire, MK16 9JJ

Overview

Theo Murphy international scientific meeting organised by Dr Jason King and Professor Joel Swanson.

Ruffling and macropinosomes formed in activated macrophages in response to pathogen detection. Pink is a Rab small GTPase, green is a membrane marker and blue is actin. Credit: Jenny Stow, University of Queensland

The engulfment of extracellular solutes or particles by macropinocytosis is an important process with newly appreciated significance for fundamental cell biology, cancer, infectious diseases and therapeutics. This first-of-its-kind meeting devoted to macropinocytosis will bring together experts from disparate fields with a shared interest in the biology of macropinosome formation and trafficking, with the goal of fostering collaboration and building a community.

The schedule of talks and speaker biographies can be found below. Recorded audio of the presentations will be available on this page after the meeting has taken place.

Poster session

There will be a poster session at 17.00 on Monday 21 May 2018. If you would like to apply to present a poster please submit your proposed title, abstract (not more than 200 words and in the third person), author list, name of the proposed presenter and institution to the Scientific Programmes team no later than Monday 26 March 2018. Please include the text 'Poster abstract submission' in the subject line. Please note that places are limited and are selected at the scientific organisers' discretion. Poster abstracts will only be considered if the presenter is registered to attend the meeting.

Short talks

There will be the opportunity to give a short talk on Tuesday 22 May 2018. If you would like to apply to give a short talk please submit your proposed title, abstract (not more than 200 words and in the third person) and institution to the Scientific Programmes team no later than Monday 26 March 2018. Please include the text 'Short talk abstract submission' in the subject line. Please note that places are limited and are selected at the scientific organisers' discretion. Abstracts will only be considered if the presenter is registered to attend the meeting.

Attending this event

This is a residential conference, which allows for increased discussion and networking.

  • Free to attend
  • Advanced registration essential
  • Catering and accommodation available to purchase during registration

Enquiries: contact the Scientific Programmes team

Event organisers

Select an organiser for more information

Schedule of talks

21 May

09:00-12:30

Session 1

4 talks Show detail Hide detail

09:05-09:30 Macropinocytosis and cellular growth control

Professor Joel Swanson, University of Michigan, USA

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09:30-09:45 Discussion

09:45-10:15 Constitutive vs inducible macropinocytosis in macrophages

Professor Sergio Grinstein, The Hospital for Sick Children, Canada

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10:15-10:30 Discussion

10:30-11:00 Coffee

11:00-11:30 Macropinocytosis and membrane recycling

Professor Julie Donaldson, National Institutes of Health, USA

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11:30-11:45 Discussion

11:45-12:15 Building a cup by coordinated regulation of small GTPases during macropinosome formation

Dr Jason King, University of Sheffield, UK

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12:15-12:30 Discussion

12:30-13:30 Lunch

13:30-18:30

Session 2

3 talks Show detail Hide detail

13:30-14:00 Unexpected roles for macropinocytosis in cell migration

Professor Ana-Maria Lennon-Duménil, Institut Curie, France

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14:00-14:15 Discussion

14:15-14:45 Macropinocytosis: Ras and PIP3 driven endocytosis

Professor Rob Kay, MRC Laboratory for Molecular Biology, UK

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14:45-15:00 Discussion

15:00-15:30 Tea

15:30-16:00 Macropinosomes: launch-pads for inflammation in macrophages

Professor Jenny Stow, University of Queensland, Australia

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16:00-16:15 Discussion

16:15-18:30 Poster session

22 May

09:00-12:30

Session 3

4 talks Show detail Hide detail

09:00-09:30 Dr Jason Mercer, MRC Laboratory for Molecular and Cellular Biology, UK

09:30-09:45 Discussion

09:45-10:35 Short talks

10:35-11:00 Coffee

11:00-11:30 Macropinocytosis through the eyes of Ebolavirus

Professor Robert Davey, Texas Biomedical Research Institute, USA

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11:30-11:45 Discussion

11:45-12:35 Short talks

12:35-13:30 Lunch

13:30-17:00

Session 4

5 talks Show detail Hide detail

13:30-14:00 Regulation of macropinocytosis in Ras-driven tumours

Dr Cosimo Commisso, NCI Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, USA

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14:00-14:15 Discussion

14:15-14:45 Feeding through engulfment

Dr Michael Overholtzer, Memorial Sloan Kettering Cancer Center, USA

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14:45-15:00 Discussion

15:00-15:30 Tea

15:30-15:45 Delivering therapeutic macromolecules into cells – challenges and opportunities

Dr Ralph Minter, Medimmune, UK

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15:45-16:00 Enhancing intracellular delivery of therapeutic mRNA

Dr Arpan Desai, AstraZeneca, UK

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16:00-16:15 Discussion

16:15-17:00 Overview and future directions

Event downloads

Macropinocytosis in physiology, disease and therapy Kavli Royal Society Centre, Chicheley Hall Newport Pagnell Buckinghamshire MK16 9JJ