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Understanding the endosomal network in neurodegeneration

Online event

Overview

Online discussion meeting organised by Professor Peter Cullen, Professor Peter St George-Hyslop, Professor Scott Small and Dr Henne Holstege.

Cryo-ET image of the yeast retromer complex associated with membrane tubules. Credit Brett M Collins

Abnormalities in the endosomal network are a signature feature of Alzheimer's disease, Parkinson's disease and numerous other neurological disorders. In bringing together world leading researchers from a range of disciplines, this meeting seeks to discuss the latest advances in this rapidly moving field and foster collaborative efforts to enhance the rate of discovery in this medically important research field.

The schedule of talks and speaker biographies are available below. Speaker abstracts will be available closer to the meeting date.

Poster session

There will be a poster session at this meeting. If you would like to apply to present a poster please submit your proposed title, abstract (not more than 200 words and in third person), author list, name of the proposed presenter and institution to the Scientific Programmes team no later than 28 September 2020. Please include the text ‘Poster abstract submission’ in the email subject line. Please note that places are limited and posters are selected at the scientific organiser’s discretion. Poster abstracts will only be considered if the presenter is registered to attend the meeting.

Attending this event

This event is intended for researchers in relevant fields and will take place online. Please register to attend to receive the joining instructions closer to the meeting date.

Enquiries: contact the Scientific Programmes team

Schedule of talks

09 November

Session 1 10:00-12:00

Mechanistic endosomal cargo sorting

7 talks Show detail Hide detail

10:00-10:05 Introduction

10:05-10:25 The role of AP-5/SPG15/SPG11 in endo-lysosomal homeostasis

Dr Jennifer Hirst, Cambridge Institute for Medical Research, UK

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10:25-10:45 Speaker tbc

10:45-11:05 Professor Peter Cullen, University of Bristol, UK

11:05-11:25 Endosomal coat assembly and regulation in neurodegeneration

Dr Lauren Parker Jackson, Vanderbilt University, USA

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11:25-11:45 De novo macrocyclic peptides for inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex

Professor Brett Collins, The University of Queensland, Australia

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11:45-12:00 Selected poster presentations

Session 2 13:00-15:00

Live panel discussion

1 talk Show detail Hide detail

13:00-15:00 Live panel discussion

Dr Jennifer Hirst, Cambridge Institute for Medical Research, UK
Dr Lauren Parker Jackson, Vanderbilt University, USA
Professor Brett Collins, The University of Queensland, Australia

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Session 3 16:00-17:00

Early career 'table' discussions

1 talk Show detail Hide detail

16:00-17:00 Early career 'table' discussions

Dr Jennifer Hirst, Cambridge Institute for Medical Research, UK
Dr Lauren Parker Jackson, Vanderbilt University, USA

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10 November

Session 1 10:00-12:00

Endo-lysosomal deregulation in neurodegeneration I

6 talks Show detail Hide detail

10:00-10:20 Professor Scott Small, Columbia University, USA

10:20-10:40 Roles of the endo-lysosomal system in dementia initiation and pathogenesis

Professor Rick Livesey, UCL/Great Ormond Street Institute of Child Health, UK

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10:40-11:00 Proteostasis in dendrites: regulating endosomal flux for lysosomal degradation

Dr Bettina Winckler, University of Virginia Medical School, USA

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11:20-11:40 Speaker tbc

11:20-11:40 SORL1 function and dysfunction in Alzheimer’s disease

Professor Olav Andersen, Aarhus University, Denmark

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11:40-11:55 Selected poster presentations

Session 2 13:00-15:00

Live panel discussion

1 talk Show detail Hide detail

13:00-15:00 Live panel discussion

Professor Rick Livesey, UCL/Great Ormond Street Institute of Child Health, UK
Dr Bettina Winckler, University of Virginia Medical School, USA
Professor Olav Andersen, Aarhus University, Denmark

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Session 6 16:00-17:00

Early career 'table' discussions

1 talk Show detail Hide detail

16:00-17:00 Early career 'table' discussions

Professor Rick Livesey, UCL/Great Ormond Street Institute of Child Health, UK
Dr Bettina Winckler, University of Virginia Medical School, USA
Professor Olav Andersen, Aarhus University, Denmark

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11 November

Session 1 10:00-12:00

Endo-lysosomal deregulation in neurodegeneration II

6 talks Show detail Hide detail

10:00-10:20 The role of the LRRK2-Rab signalling pathway in regulating endo-lysosomal biology and Parkinson’s disease

Professor Dario Alessi, University of Dundee, UK

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10:20-10:40 Unravelling the downstream effects of endolysosomal dysfunction on the gut-brain axis in Parkinson's disease

Dr Kerri Kinghorn, University College London, UK

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10:40-11:00 LRRK2 activation and pathobiology of Parkinson’s disease

Dr Mark Cookson, NIA, NIH, USA

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11:00-11:20 Endo-lysosomal dysfunction – a unifying mechanism for hereditary spastic paraplegia

Dr Evan Reid, Cambridge Institute of Medical Research, UK

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11:20-11:40 Axonal autophagy and neurodegeneration

Professor Erika Holzbaur, University of Pennsylvania, USA

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11:40-11:55 Selected poster presentations

Session 2 13:00-15:00

Live panel discussion

1 talk Show detail Hide detail

13:00-15:00 Live panel discussion

Professor Dario Alessi, University of Dundee, UK
Dr Kerri Kinghorn, University College London, UK
Dr Evan Reid, Cambridge Institute of Medical Research, UK

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Session 3 16:00-17:00

Early career 'table' discussions

1 talk Show detail Hide detail

16:00-17:00 Early career 'table' discussions

Professor Dario Alessi, University of Dundee, UK
Dr Kerri Kinghorn, University College London, UK
Dr Evan Reid, Cambridge Institute of Medical Research, UK

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12 November

Session 1 10:00-12:00

Genetics of endo-lysosomal neurodegenerative disease

6 talks Show detail Hide detail

10:00-10:20 Dr Henne Holstege, Amsterdam UMC, The Netherlands

10:20-10:40 Professor Peter St George-Hyslop FRS, Cambridge Institute for Medical Research, UK and University of Toronto, Canada

10:40-11:00 Speaker tbc

11:00-11:20 Therapeutic effects of retromer stabilization in Amyotrophic Lateral Sclerosis models

Professor Pierfausto Seneci, University of Milan, Italy
Dr Luca Muzio, San Raffaele Scientific Institute, Italy

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11:20-11:40 Speaker tbc

11:40-11:55 Selected poster presentations

Session 2 13:00-15:00

Live panel discussion

Session 3 16:00-17:00

Early career 'table' discussions

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