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The Francis Crick Lecture 2022 given by Professor Serena Nik-Zainal.

Professor Serena Nik-Zainal developed expertise in cancer whole genome sequence (WGS) analysis and interpretation just as next-generation sequencing approaches were coming to the fore. With only 21 breast cancer WGS samples available in 2012, it became clear that human cancers were highly individual. Each cancer is profoundly marked by an extensive amount of mutagenesis, all previously hidden, prior to the advent of WGS. Etched into the DNA of cancers are graffiti-like mutation patterns, which could be informative of underlying biological abnormalities, unique to each person’s cancer, with potential for application in precision medicine. 

In this lecture, Professor Nik-Zainal will describe how her team have explored the extraordinary DNA graffiti that has been seen in human cancers, using a combination of big data computational approaches and systematic experimental methods. She will provide an account of how they have designed algorithms that could be used to interpret cancer genomes for clinical purposes and how they have taken steps towards clinical validation studies for her algorithms. Professor Nik-Zainal will touch on her team’s recent endeavour, reporting the largest cohort of WGS cancers worldwide of nearly 20,000 patients recruited via the NHS. She will end by bringing the audience through a selection of real cancer WGS patient stories.

Attending the event

  • The event is free to join
  • Registration is recommended to attend in person otherwise availability cannot be guaranteed
  • Live subtitles will be available in person and online.

Attending in person 

  • This lecture can be attended in person at the Royal Society
  • Doors will open to the public at 6pm
  • Registration is recommended if attending in person, otherwise availability cannot be guaranteed
  • Travel and accessibility information

Attending live online

  • The lecture will also be livestreamed here and on the Royal Society YouTube channel
  • You can take part in the live Q&A which will be available on this page
  • This event will be recorded (including the live Q&A) and the recording will be available on YouTube soon after the event
  • The Royal Society has an acceptable use policy for all online events, and we expect our users to abide by these guidelines.

The award

The Francis Crick Medal and Lecture is awarded annually in any field in the biological sciences. Preference is given to genetics, molecular biology and neurobiology, the general areas in which Francis Crick worked, and to fundamental theoretical work, which was the hallmark of Crick’s science.

The lectureship was endowed by Sydney Brenner FRS in memory of Francis Crick FRS, the co-discoverer of the structure of the DNA molecule. The first lecture was given in 2003. The medal is of bronze, is awarded annually and is accompanied by a gift of £2,000.

Enquiries: contact the Events team.