The promises and pitfalls of preregistration

04 - 05 March 2024 09:00 - 17:00 The Royal Society Free

Discussion meeting organised by Dr Tom Hardwicke, Professor Marcus Munafò, Dr Sophia Crüwell, Professor Dorothy Bishop FRS FMedSci, Professor Eric-Jan Wagenmakers.

Serious concerns about research quality have provoked debate across scientific disciplines about the merits of preregistration — publicly declaring study plans before collecting or analysing data. This meeting will initiate an interdisciplinary dialogue exploring the epistemological and pragmatic dimensions of preregistration, identifying potential limits of application, and developing a practical agenda to guide future research and optimise implementation.

The schedule of talks, speaker biographies and abstracts are available below.  

Attending the meeting

This meeting is intended for researchers in relevant fields.

  • Free to attend
  • Both in person and online attendance available
  • Please register to attend via Eventbrite. An optional lunch is also available to purchase. 

Enquiries: contact the Scientific Programmes Team

Organisers

  • Dr Tom Hardwicke

    Dr Tom Hardwick, University of Melbourne, Australia

    Dr Tom Hardwicke is a Research Fellow at the School of Psychological Sciences, University of Melbourne. He received his PhD in Experimental Psychology from University College London in 2016 and subsequently completed post-doctoral fellowships at the Meta-Research Innovation Center at Stanford University (METRICS), The QUEST Center for Responsible Research at Charité, Universitätsmedizin Berlin, and the Department of Psychology at the University of Amsterdam. Tom works on a variety of meta-research (‘research-on-research’) projects related to transparency, bias, peer review, scientific criticism, and reproducibility.

  • Professor Marcus Munafò

    Professor Marcus Munafò, University of Bristol, UK

    Marcus Munafò is Associate Pro-Vice Chancellor for Research Culture at the University of Bristol, and Chair of the UK Reproducibility Network Steering Group. He completed his undergraduate degree in Psychology and Philosophy at the University of Oxford, and his PhD at the University of Southampton. He completed postdoctoral fellowships at the University of Oxford and the University of Pennsylvania, before moving to the University of Bristol. He has a long standing interest in the factors – individual and structural – that contribute to research quality, and in developing and evaluating interventions at all levels of the research ecosystem designed to improve research quality. In 2019 he co-founded the UK Reproducibility Network.

  • Dr Sophia Crüwell

    Dr Sophia Crüwell, University of Cambridge, UK

    Sophia Crüwell is currently working on a PhD in Philosophy of Science at the University of Cambridge. The focus of her philosophical research is on conceptual issues surrounding the replication crisis in Psychology, including replication, questionable research practices, and incentive structures in science. 

    Sophia also does meta-research, working on empirical projects on open and reproducible science. Outside of her academic research, she is passionate about advocating for open research and co-founded and is part of the steering committee of the international ECR community ReproducibiliTea. 

  • Professor Dorothy Bishop FMedSci FBA, University of Oxford, UK

    Dorothy Bishop studied Experimental Psychology at Oxford University and Clinical Psychology at the Institute of Psychiatry, London, before completing a D.Phil in neuropsychology back at Oxford. She was for 20 years funded by the Medical Research Council before moving in 1998 to the Department of Experimental Psychology in Oxford to take up her Wellcome Principal Research Fellowship. She is a Fellow of the British Academy and the Academy of Medical Sciences.

    Her research focuses on the nature and causes of children’s communication problems, encompassing psychological, linguistic, neurological and genetic aspects. Her book Uncommon Understanding won the British Psychology Society’s annual book prize in 1998. As well as publishing in conventional academic outlets, she writes a popular blog which was a runner-up in the Good Thinking Society’s UK Science Blog 2012 prize. She is a founder of a YouTube campaign for Raising Awareness of Language Learning Impairments.

  • Professor Eric-Jan Wagenmakers

    Professor Eric-Jan Wagenmakers, University of Amsterdam, the Netherlands

    Dr Eric-Jan ("EJ") Wagenmakers is Professor in Bayesian Methodology at the Psychological Methods Unit of the University of Amsterdam. His main research interest is Bayes factor hypothesis testing in the style of Sir Harold Jeffreys. Wagenmakers's lab spearheads the development of the JASP open-source software program for statistical analyses. Wagenmakers is also a strong advocate of Open Science and the preregistration of analysis plans.

Schedule

Chair

Dr Evan Mayo-Wilson

Dr Evan Mayo-Wilson, University of North Carolina, USA

09:05-09:30 A brief history of clinical trial registration

Clinical trial registration has become an essential part of biomedical research. Laws require it, international organisations encourage it, and journal publication is often not possible without it. This talk will explore how the prospective registration of clinical trials became an ethical, legal, and practical requirement and examine in the infrastructure that has supported the growth of the practice. This will enable a discussion of the unique facets that led to the broad uptake of prospective registration in the field of clinical trials as well as what aspects are transferrable to other areas.

Dr Nicholas DeVito, University of Oxford, UK

Dr Nicholas DeVito, University of Oxford, UK

09:30-10:00 Psychology: from crisis to change

Psychology went into a severe crisis: Major fraud cases came to light, prominent research findings failed to replicate, and the use of Questionable Research Practices (QRPs) in the collection and analysis of data and reporting of results appeared to be widespread. This crisis resulted in a call for more transparency and openness to improve psychological science. Preregistration, which is registering the hypothesis, study design, and data-analysis plan prior to data collection, was proposed to guarantee a study's confirmatory nature and increase the research process's transparency. Preregistration has become more and more common in recent years. Different preregistration templates have been developed to guide researchers in preregistering their studies, and several journals award preregistration badges. On the other hand, meta-research into these preregistrations shows that these preregistrations are often not specific enough and that the preregistered plans are not always followed. In this talk, Marjan Bakker will present the history of preregistration in psychology, how it is currently used, and present research that investigates the effectiveness of preregistration.

Dr Marjan Bakker, Tilburg University, the Netherlands

Dr Marjan Bakker, Tilburg University, the Netherlands

10:00-10:30 Break
10:30-11:00 A history of preregistration

Professor Fidler's abstract will follow shortly.

Professor Fiona Fidler, University of Melbourne, Australia

Professor Fiona Fidler, University of Melbourne, Australia

11:00-11:30 Do pre-registration and pre-analysis plans reduce p-hacking and publication bias? Evidence from the universe of RCTs in Economics and suggestions for improvement

Randomised controlled trials (RCTs) are increasingly prominent in academic economics and their results are influential in policy circles. Pre-registration is regarded as an important contributor to research credibility. We investigate this by analysing the pattern of test statistics from the universe of RCT studies published in 15 leading economics journals from 2018 through 2021. Broadly, we draw two conclusions: (a) In contrast to other disciplines, pre-registration in economics frequently does not involve a pre-analysis plan (PAP), or sufficient detail to constrain meaningfully the actions and decisions of researchers after data is collected. Consistent with this, we find no evidence that pre-registration in itself reduces p-hacking and publication bias. (b) When pre-registration is accompanied by a PAP we find evidence consistent with both reduced p-hacking and publication bias. We make some policy proposals and hope the analysis can contribute to the ongoing debate about the appropriate approach to pre-registration in economics.

Dr Abel Brodeur, University of Ottawa, Canada

Dr Abel Brodeur, University of Ottawa, Canada

11:30-12:15 Response and discussion

Speakers from the session to respond to each other's talks. This will be followed by an open discussion.

Dr Marjan Bakker, Tilburg University, the Netherlands

Dr Marjan Bakker, Tilburg University, the Netherlands

Professor Fiona Fidler, University of Melbourne, Australia

Professor Fiona Fidler, University of Melbourne, Australia

Dr Nicholas DeVito, University of Oxford, UK

Dr Nicholas DeVito, University of Oxford, UK

Chair

Professor Simine Vazire

Professor Simine Vazire, University of Melbourne, Australia

13:15-13:45 Lightning talks

Lightning talks on meta-research, ideas and tools. The session is to be filled by an open call and Dr Jessie Baldwin will Chair.

Dr Jessie Baldwin, UCL, UK

Dr Jessie Baldwin, UCL, UK

13:45-14:15 Title to be confirmed

Speaker to be confirmed. Abstract to follow shortly.

14:15-14:45 Statistical practice as scientific exploration

Much has been written on the philosophy of statistics: How can noisy data, mediated by probabilistic models, inform our understanding of the world? Researchers when using and developing statistical methods can be seen to be acting as scientists, forming, evaluating, and elaborating provisional theories about the data and processes they are modelling. This perspective has the conceptual value of pointing toward ways that statistical theory can be expanded to incorporate aspects of workflow that were formally tacit or informal aspects of good practice, and the practical value of motivating tools for improved statistical workflow.

Professor Andrew Gelman, Columbia University, USA

Professor Andrew Gelman, Columbia University, USA

14:45-15:15 Break
15:15-15:45 The epistemic benefits of registered reports and policy opportunities

Many arguments for the benefits of registered reports focus on the way in which they reduce the incentives for questionable research practices (QRPs) such as HARKing and p-hacking. In the context of the prediction vs. accommodation debate, I will discuss why it is important to reduce QRPs. I also want to bring additional possible benefits of registered reports into focus. The first is that accepting registered report proposals should include peer review of detailed methodologies, and the timing of such review can be particularly beneficial. Instead of reviewing a paper when the work is already completed, the peer review could improve the methodologies before the work is done, thus strengthening the evidential warrant for whatever results emerge. Registered reports also would allow for the publication of a broader swath of scientific practice, so scientists can know what has not worked. In addition, if registered reports became the norm, it would allow for better tracking of what scientists are attempting and pursuing, allowing for clearer assessments of the range research efforts in a field. Finally, peer reviewed methodologies accepted for publication could be tied to funding pools. If a proposal for research passes through peer review for a registered report publication, the proposal would meet the minimum standards for a funding lottery system (which has other benefits for science). In short, registered reports could change the way science is pursued in a number of salutary ways if we made accompanying policy shifts to take advantage of them.

Professor Heather Douglas, Michigan State University, USA

Professor Heather Douglas, Michigan State University, USA

15:45-16:15 Preregistration will not improve our theories

Proponents of preregistration argue that, among other benefits, it improves the diagnosticity of statistical tests. In the strong version of this argument, preregistration does this by solving statistical problems, such as family-wise error rates. In the weak version, it nudges people to think more deeply about their theories, methods, and analyses. We argue against both: the diagnosticity of statistical tests depend entirely on how well statistical models map onto underlying theories, and so improving statistical techniques does little to improve theories when the mapping is weak. There is also little reason to expect that preregistration will spontaneously help researchers to develop better theories (and, hence, better methods and analyses).

Professor Chris Donkin, LMU Munich, Germany

Professor Chris Donkin, LMU Munich, Germany

16:15-17:00 Response and discussion

Speakers from the session to respond to each other's talks. This will be followed by an open discussion.

Professor Andrew Gelman, Columbia University, USA

Professor Andrew Gelman, Columbia University, USA

Professor Chris Donkin, LMU Munich, Germany

Professor Chris Donkin, LMU Munich, Germany

Professor Isabelle Boutron, Université Paris Cité, France

Professor Isabelle Boutron, Université Paris Cité, France

17:00-18:00 Poster session

Chair

Professor Eric-Jan Wagenmakers

Professor Eric-Jan Wagenmakers, University of Amsterdam, the Netherlands

09:00-09:30 The epistemic status of pre-registration

We have witnessed the emergence of a new epistemic norm: pre-registration. On what basis do epistemic norms get their normative status? That is, when some rule says that scientists should do x, where does that should come from? Many of us are implicitly committed to epistemic consequentialism, which holds that epistemic norms are warranted if and only if they are truth-conducive. On this view pre-registration comes out looking pretty good. The epistemic benefits of pre-registration (roughly, a decrease in false-positives due to the mitigation of publication bias and p-hacking) plausibly outweigh, in some contexts, the epistemic costs (roughly, an increase in false-negatives due to constraints on researcher degrees of freedom). This is often but not generally so: for example, all the great discoveries in medicine were pre-pre-registration, yet the corrupted context of current clinical research clearly favours pre-registration. Epistemic non-consequentialism, on the other hand, holds that epistemic norms are warranted to the extent that they manifest and promote epistemic agency and responsibility. I will argue for epistemic non-consequentialism. On this view pre-registration comes out looking a little less shiny. If scientists were transparent about their methods and were appropriately cautious with their inferences, pre-registration would be unnecessary. Yet many scientists lack such transparency and epistemic humility, particularly in domains in which incentives are corrupted by fame and money, and therefore pre-registration is helpful. While some domains of science today need honesty-enforcement mechanisms, this is a fact to be greeted by a sigh rather than a smile.   

Professor Jacob Stegenga, University of Cambridge, UK

Professor Jacob Stegenga, University of Cambridge, UK

09:30-10:00 Preregistration: Panacea or proxy?

The purpose of preregistration of is to reduce the researcher’s degrees of freedom that might otherwise compromise analysis and interpretation of the results. The idea is that by preregistering hypotheses, methodology, sampling plan, and an analysis plan, inconvenient outcomes cannot be addressed by altering hypotheses after the fact or by continuing data collection and exploring different analyses until the results conform to expectations. Professor Lewandowsky argues that it is helpful to disentangle the distinct purposes of preregistration and evaluate each in isolation. Concerning hypotheses, preregistration ensures that theorising cannot be informed by the data being collected by enforcing a strict temporal order between the two. However, temporal order is only a proxy for differentiating between a priori predictions and unimpressive post hoc explanations. Temporal order is entirely irrelevant if the independence of theorising from data collection is ensured in other ways, for example if a computational model is proposed without consideration or knowledge of existing data. Concerning analysis, preregistration ensures that a researcher cannot explore the 'garden of forking paths' by conducting numerous analyses, each involving subtly different choices, and then picking the desired outcome. However, preregistration of a single analysis is entirely arbitrary if multiple justifiable options exist, which creates the risk of missing an interesting pattern that might have been revealed by most or all of the other justifiable options. An alternative to preregistration of as single analysis would therefore involve a 'multiverse' analysis that explores many different forking paths to establish the robustness of a result. Finally, concerning the sampling plan, preregistration ensures that data collection and exclusion of participants is not governed by knowledge of interim results, thus curtailing researchers’ ability to shape the outcome through arbitrary decisions. Professor Lewandowsky argues that specification of the sampling plan and exclusion criteria is the most important aspect of preregistration because—unlike hypothesising and analysis—problems that are introduced during data collection cannot be retroactively examined or fixed.

Professor Stephan Lewandowsky, University of Bristol, UK

Professor Stephan Lewandowsky, University of Bristol, UK

10:00-10:30 Break
10:30-11:00 The promise and pitfalls of preregistration

Isabelle Boutron will discuss the need for pre-registration of protocol, the implementation of pre-registration in some domains and how pre-registration could improve research practices. She will also highlight the barriers and limitations of pre-registration.

Professor Isabelle Boutron, Université Paris Cité, France

Professor Isabelle Boutron, Université Paris Cité, France

11:00-11:30 Exploration versus confirmation, tests versus models, mature versus immature sciences, and the role of preregistration

Progress in science loosely follows a similar pattern: scientists observe phenomena, develop measures to objectively assess said phenomena, build theories (models) of these phenomena, then evaluate, test, and refine these models. As such, methodologies generally begin with primarily exploratory approaches (e.g., exploratory data analysis, or EDA) then progress toward confirmatory approaches (e.g., confirmatory data analysis or CDA) as that science matures. Unfortunately, immature sciences (e.g., psychology) have a history of borrowing methodologies (e.g., confirmatory data analytic approaches) from mature sciences long before they are fully ready to leverage these methodologies. These approaches and their corresponding probability-based statistics (e.g., p-values and confidence intervals) only have probabilistic meaning if one’s models are adequately mature. Preregistration, in a sense, was designed to address this problem by forcing researchers to pre-specify which analyses were confirmatory (and, presumably, reflect mature theories). However, without adequate understanding of the exploratory/confirmatory continuum and how methodologies must adapt to the maturity of one’s models, preregistration is insufficient; too many will attempt confirmatory methods prematurely and be disappointed in results. In this paper, Dr Fife will argue that the standard statistics curriculum has necessarily led to the replication crisis and the only way to build a replicable science will require a re-education that focuses on model building, cumulative research, and a clear understanding of the role of EDA/CDA.

Dr Dustin Fife, Rowan University, USA

Dr Dustin Fife, Rowan University, USA

11:30-12:15 Response and discussion

Speakers from the session to respond to each other's talks. This will be followed by an open discussion.

Dr Dustin Fife, Rowan University, USA

Dr Dustin Fife, Rowan University, USA

Professor Heather Douglas, Michigan State University, USA

Professor Heather Douglas, Michigan State University, USA

Professor Jacob Stegenga, University of Cambridge, UK

Professor Jacob Stegenga, University of Cambridge, UK

Professor Stephan Lewandowsky, University of Bristol, UK

Professor Stephan Lewandowsky, University of Bristol, UK

Chair

Dr Hilda Bastian

Dr Hilda Bastian, Independent, Australia

13:15-13:45 Peer community in registered reports: embracing the promises and avoiding the pitfalls of preregistration

Registered Reports are a form of empirical publication, offered by over 350 journals, in which study proposals are peer reviewed, preregistered, and pre-accepted before research is undertaken. By deciding which articles are published based on the question, theory, and methods, Registered Reports offer a remedy for a range of reporting and publication biases. In this talk, Professor Chambers will summarise the progress of a relatively new platform for supporting Registered Reports called the Peer Community in Registered Reports (PCI RR). PCI RR is a non-profit, non-commercial platform that, like the many other PCIs, coordinates the peer-review of preprints but in this case specifically for RRs. PCI RR is also joined by a growing fleet of  'PCI RR-friendly' journals that agree to endorse the recommendations of PCI RR without further review, giving the authors the power to choose which journal, if any, will publish their manuscript. By reclaiming control of the peer review process from academic publishers, PCI RR provides a mechanism for ensuring that Registered Reports are made as open, accessible, and rigorous as possible, while also moving toward a future in which journals themselves become obsolete in their current form.

Professor Chris Chambers, Cardiff University, UK

Professor Chris Chambers, Cardiff University, UK

13:45-14:15 Title to be confirmed

Dr Anne Scheel's abstract will follow shortly.

14:15-14:45 Preregistration: Known, unknown, and what's next

Preregistration is an interesting enough methodological innovation to generate productive debate about what it is, what it is for, and when it is useful. Some insights are revealed in theoretical discussion about preregistration. Other insights are revealed experientially and empirically by treating preregistration as a product in research and development. To what extent are the core purposes of preregistration adaptable to different types of scholarly inquiry? To what extent does the practice of preregistration benefit different types of scholarly inquiry? How can preregistration be improved to decrease the costs and increase the benefits? What are the boundary conditions for which the cost/benefit trade-off favours not using preregistration? After learning from the other presentations at this meeting, I am hoping to have something sensible to say about questions like these.

Professor Brian Nosek, Center for Open Science, USA

Professor Brian Nosek, Center for Open Science, USA

14:45-15:15 Response and discussion

Speakers from the session to respond to each other's talks. This will be followed by an open discussion.

Professor Brian Nosek, Center for Open Science, USA

Professor Brian Nosek, Center for Open Science, USA

Professor Chris Chambers, Cardiff University, UK

Professor Chris Chambers, Cardiff University, UK

15:15-15:45 Break
15:45-17:00 Meeting reflection panel

The five chairs of the meeting will reflect, highlight common ground, challenges and future directions. This will be followed by an open discussion and will be chaired by Sophia Crüwell.

Dr Jessie Baldwin, UCL, UK

Dr Jessie Baldwin, UCL, UK

Dr Evan Mayo-Wilson, University of North Carolina, USA

Dr Evan Mayo-Wilson, University of North Carolina, USA

Professor Simine Vazire, University of Melbourne, Australia

Professor Simine Vazire, University of Melbourne, Australia

Dr Hilda Bastian, Independent, Australia

Dr Hilda Bastian, Independent, Australia

Professor Eric-Jan Wagenmakers, University of Amsterdam, the Netherlands

Professor Eric-Jan Wagenmakers, University of Amsterdam, the Netherlands