Engineering biology
Exploring what is needed to realise the full potential of the UK's engineering biology sector.
Engineering biology refers to the use of specialist tools and technologies to produce biology-derived processes and products, which are often more sustainably produced than their existing counterparts. Engineering biology is one of five critical technologies identified by the Department for Science, Innovation and Technology (DSIT) as areas where the UK is in an excellent position to lead the world.
However, as this field continues to rapidly advance, it is vital that we are able to translate and apply ground-breaking research into commercial settings through innovation that is trustworthy and responsible.
This conference will explore the translation journey of new technology from the laboratory to the market, how responsible innovation can be facilitated, what is needed to improve UK infrastructure as well as what funding mechanisms could be employed to realise the full potential of these innovations.
Transforming our future conferences
This conference forms part of the Royal Society's industry-focused Transforming our future series. These unique meetings feature cutting-edge science and bring together experts from industry, academia and government to explore and address key scientific and technical challenges of the coming decade.
Organisers
Schedule
09:30-09:40 |
Welcome and opening remarks
Sir David BaulcombeCambridge University Sir David BaulcombeCambridge University David Baulcombe is a plant molecular biologist with an interest in disease resistance. He and his group discovered small RNA and various protein components of an RNA silencing system that protects plants against viruses and affects patterns of plant gene expression. David’s work has been recognised by awards including the Gruber Genetics Prize (2014), the Balzan Prize (2012) (for epigenetics), the Wolf Prize for Agriculture (2010) the Albert Lasker Award for Basic Medical Research (2008) and a Royal Medal (2006) of the Royal Society. He is an International Member of the National Academy of Sciences (USA) (elected 2005) and was made a Knight Bachelor in 2009. Since 2007 he is Professor of Botany (Regius since 2012) (now Emeritus) in Cambridge and he was a Royal Society Research Professor (2007-2022). Professor Martin Dawson FRSUniversity of Strathclyde Professor Martin Dawson FRSUniversity of Strathclyde Martin Dawson is professor and director of research at the University of Strathclyde’s Institute of Photonics, which he helped establish almost 25 years ago. Since 2012 he has also been the inaugural Head of the Fraunhofer Centre for Applied Photonics (Fraunhofer CAP) in Glasgow. Martin has contributed broadly to laser and semiconductor research including ultrafast lasers, optically-pumped semiconductor lasers, diamond photonics and micro-LEDs, the latter of which is now emerging globally as a new form of commercial display technology. He holds fellowships of the IEEE, OSA, Institute of Physics and Royal Society of Edinburgh, and he has been awarded the Dennis Gabor Medal and Prize of the IOP and the Aron Kressel Award of the IEEE. |
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09:40-10:05 |
Opening keynote
In terrestrial life, DNA is copied to messenger RNA, and the 64 triplet codons in messenger RNAs are decoded – in the process of translation – to synthesize proteins. Cellular protein translation provides the ultimate paradigm for the synthesis of long polymers of defined sequence and composition, but is commonly limited to polymerizing the 20 canonical amino acids. I will describe our progress towards the encoded synthesis of non-canonical biopolymers. These advances may form a basis for new classes of genetically encoded polymeric materials and medicines. To realize our goals we are re-imagining some of the most conserved features of the cell; we have created new ribosomes, new aminoacyl-tRNA synthetase/tRNA pairs, and organisms with entirely synthetic genomes in which we have re-written the genetic code. Professor Jason ChinMRC Laboratory of Molecular Biology Professor Jason ChinMRC Laboratory of Molecular Biology Jason Chin is a Programme Leader at the Medical Research Council Laboratory of Molecular Biology (MRCLMB), where he is also Head of the Centre for Chemical & Synthetic Biology (CCSB). He is a Professor of Chemistry & Chemical Biology at the University of Cambridge, and holds a joint appointment at the University of Cambridge Department of Chemistry. He is also a fellow in Natural Sciences at Trinity College, Cambridge. Jason is a native of the UK. He was an undergraduate at Oxford University, where he worked with Professor John Sutherland on Cephalosporin biosynthesis. He obtained his PhD as a Fulbright awardee from Yale University, working with Professor Alanna Schepartz. He was a Damon Runyon Fellow at The Scripps Research Institute with Professor Peter Schultz where he developed the first approaches to systematically expand the genetic code of eukaryotic cells and pioneered approaches, that are now widely used, for defining protein interactions by genetically encoding photocrosslinking amino acids. Jason’s work has been recognized by a number of awards, including: the Francis Crick Prize (Royal Society), the Corday Morgan Prize (Royal Society of Chemistry), European Molecular Biology Organization’s (EMBO) Gold Medal, Louis-Jeantet Young Investigator Career Award, Sackler International Prize in the Physical Science. He is in the European Inventors Hall of Fame, a member of EMBO, a Fellow of the Academy of Medical Sciences, and a Fellow of The Royal Society. Jason’s early work provided a foundation for Ambrx and he is the founder and CSO of Constructive Bio. He is also a non-executive director at the UK Government’s Department of Science, Innovation and Technology. |
Chair
Dr David Tew
GSK
Dr David Tew
GSK
10:05-10:10 |
Introduction to Session 1
Dr David TewGSK Dr David TewGSK |
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10:10-10:25 |
Early discovery research
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10:25-10:40 |
Spinout story
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10:40-10:55 |
The role of IP in real-world impact
Dr Sara HollandPotter Clarkson LLP Dr Sara HollandPotter Clarkson LLP Sara completed a PhD in chromosome engineering before working as a postdoctoral researcher for eight years in yeast molecular biology. She has been at Potter Clarkson as a patent attorney for the past ten years, working mostly with scientist founders and SMEs in biotechnology, with a particular focus on synthetic biology. Because of her academic background, she is keen to increase knowledge of IP and the crucial role it plays in getting our research out of the lab into the real world. |
10:55-11:05 |
Q&A
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Chair
Professor Anne Osbourn
John Innes Centre
Professor Anne Osbourn
John Innes Centre
11:35-11:40 |
Introduction to Session 2
Professor Anne OsbournJohn Innes Centre Professor Anne OsbournJohn Innes Centre |
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11:40-11:55 |
SAW Trust
Dr Jenni RantSAW Trust / John Innes Centre Dr Jenni RantSAW Trust / John Innes Centre Whilst studying at the John Innes Centre for my PhD in Plant Pathology, I began volunteering for the Science Art and Writing (SAW) Trust. SAW is an education charity that brings together scientists, artists and writers to take stories out of research labs and into classrooms and public spaces for people to explore current research themes through practical science, poetry and visual arts. I transitioned from postdoctoral research at JIC to become the full-time programme manager for the trust in 2012 where I oversee all aspects of SAW, from project design and delivery to fundraising, social media and engagement. Funded by charities, organisations and research councils (incl. Heritage Lottery Fund, Carnegie UK, Wellcome Trust, The Royal Society, Festival Republic, UK Research and Innovation), we have successfully delivered projects on a wide range of topics from climate change and wellbeing to food production and engineering biology. |
11:55-12:10 |
Creating responsible innovation
Professor Joyce TaitUniversity of Edinburgh Professor Joyce TaitUniversity of Edinburgh Joyce Tait (Director, Innogen Institute, University of Edinburgh) has an interdisciplinary systems analysis background linking natural and social sciences to support the delivery of innovative technologies with economic and societal benefits. She works on: industry strategic planning for innovation; responsible innovation; policies, regulation and standards; and new approaches to stakeholder engagement about technological innovation. She is currently a member of the Regulatory Horizons Council (RHC) and other recent appointments include: the Prime Minister’s Council for Science and Technology; the Synthetic Biology Leadership Council (and Chair of its Governance Subgroup); and Governing Board of the Industrial Biotechnology Innovation Centre, University of Strathclyde. She has been involved in the development of the RHC reports on Regulating Quantum Technology Applications, The Regulation of Hydrogen Fuel Propulsion in Maritime Vessels, Neurotechnology, and Genetic Technologies. She was also technical author of the BSI PAS 440 Guide to Responsible Innovation. |
12:10-12:25 |
Ethics and governance of innovation
Professor Sarah Cunningham-BurleyNuffield Council on Bioethics & University of Edinburgh Professor Sarah Cunningham-BurleyNuffield Council on Bioethics & University of Edinburgh Sarah Cunningham-Burley is Chair of the Nuffield Council on Bioethics. The Nuffield Council on Bioethics is a leading independent policy and research centre, and the foremost bioethics body in the UK. The NCOB works to inform policy and public debate by identifying, analysing and advising on ethical issues raised by developments in biomedicine and health and to embed ethics at the centre of decisions, so we all benefit. Sarah is Professor of Medical and Family Sociology and Co-director of the Wellcome supported Centre for Biomedicine, Self and Society at the Usher Institute, University of Edinburgh. This is an interdisciplinary social science and humanities research centre focusing on developments in health-related science and care. Her own research interests span the social and ethical aspects of personalized medicine, health-related AI and data science, and the integration of patient and public perspectives in research and policy. |
12:25-12:35 |
Q&A
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Chair
Dr Damian Kelly
Croda
Dr Damian Kelly
Croda
Damian holds a BSc in Chemistry, MSc in Surface Science & Catalysis and a PhD in Tribology from the University of Cambridge. Upon graduation Damian joined the Croda Graduate Development Programme in 2001. Over the past 16 years Damian has held several positions across different Croda markets, divisions and functions including Personal Care Sales Manager for Latin America, Performance Technologies Business Development Manager for North America and Life Sciences Vice President for Europe with both Technical and Commercial responsibility. Damian is presently Head of Global Research & Development for all Croda sectors, based at Croda’s manufacturing site in Widnes, Cheshire. Damian is also the technical lead for Croda’s Technology Investment Group which is responsible for the acquisition and licensing of new technologies that match the needs of all Croda’s end markets.
13:35-13:40 |
Introduction to Session 3
Dr Damian KellyCroda Dr Damian KellyCroda Damian holds a BSc in Chemistry, MSc in Surface Science & Catalysis and a PhD in Tribology from the University of Cambridge. Upon graduation Damian joined the Croda Graduate Development Programme in 2001. Over the past 16 years Damian has held several positions across different Croda markets, divisions and functions including Personal Care Sales Manager for Latin America, Performance Technologies Business Development Manager for North America and Life Sciences Vice President for Europe with both Technical and Commercial responsibility. Damian is presently Head of Global Research & Development for all Croda sectors, based at Croda’s manufacturing site in Widnes, Cheshire. Damian is also the technical lead for Croda’s Technology Investment Group which is responsible for the acquisition and licensing of new technologies that match the needs of all Croda’s end markets. |
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13:40-13:55 |
Industrialising biology for chemicals biomanufacturing
Professor Nigel S. ScruttonUniversity of Manchester Professor Nigel S. ScruttonUniversity of Manchester Nigel is Director of the UK Future Biomanufacturing Research Hub, and Founder and Director of the company C3 BIOTECH Ltd. He is former Director of the Manchester Institute of Biotechnology (2010-2020). He was elected Fellow of the Royal Society in 2020. Nigel has an established position in the field of enzyme catalysis, biophysics and biomolecular engineering. His group is noted for its contributions to catalysis science, especially in the fields of quantum biology, dynamics and biocatalysis, mechanistic and synthetic biology, and bio-based chemicals and fuels manufacture. In his work with C3 BIOTECH, he leads pilot plant developments for chemicals biomanufacturing. This uses engineering biology through systems engineering of emergent technologies, and the integration of biology and chemistry platforms at the process level. |
13:55-14:10 |
Perspective from startup
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14:10-14:25 |
Perspective from the health industry
Ted ChapmanRetired, Previously Director Biotechnology Development GSK Ted ChapmanRetired, Previously Director Biotechnology Development GSK Recently retired from GSK Ted’s experience covers large scale manufacturing of fermentation products and process development of small molecule biotechnology processes. Ted was responsible for Industrialising GSK’s Advanced Manufacturing Synthetic Biochemistry programme which moved enzyme usage from the catalyst of last resort to being present in over 50% of new small molecule processes. Ted’s team in Worthing identified, commissioned and optimised numerous natural product, enzyme and metabolic engineered processes from discovery to over 100,000l scale. Ted is passionate about the potential of biotechnology to increase the sustainability of manufacturing and create new value. Ted was a non-exec member of the IBioIC governing board for many years. |
14:25-14:40 |
Perspective from the agriculture industry
Dr Robert HarrisSyngenta Dr Robert HarrisSyngenta |
14:40-14:55 |
Q&A
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Chair
Dr Christopher Kaminker
BlackRock Investment Institute (BII)
Dr Christopher Kaminker
BlackRock Investment Institute (BII)
Christopher Kaminker, PhD, Managing Director, is Head of the Sustainable Investment Research & Analytics (SIRA) team within the BlackRock Investment Institute (BII). SIRA comprises the BSI Intel, Climate & Sustainability Research and APAC Sustainable Investment Research teams. He is as well, the Deputy Head of Sustainable and Transition Solutions (STS). He is a member of BlackRock's Sustainable and Transition Investment Committee, and EMEA Investments Committee.
Prior to joining BlackRock, Chris was Group Head of Sustainable Investment at Lombard Odier, a Swiss private bank and asset manager. He led a group responsible for sustainable investment research, data science and analytics, product development, portfolio strategy and stewardship. Chris is an energy economist and economic geographer by training, a Visiting Business Fellow at the Smith School of Enterprise and the Environment at Oxford University, and a Fellow of the Royal Geographical Society. He received his PhD from Oxford University and masters from Columbia University (SIPA).
15:25-15:35 |
Introduction to panel
Dr Christopher KaminkerBlackRock Investment Institute (BII) Dr Christopher KaminkerBlackRock Investment Institute (BII) Christopher Kaminker, PhD, Managing Director, is Head of the Sustainable Investment Research & Analytics (SIRA) team within the BlackRock Investment Institute (BII). SIRA comprises the BSI Intel, Climate & Sustainability Research and APAC Sustainable Investment Research teams. He is as well, the Deputy Head of Sustainable and Transition Solutions (STS). He is a member of BlackRock's Sustainable and Transition Investment Committee, and EMEA Investments Committee. Prior to joining BlackRock, Chris was Group Head of Sustainable Investment at Lombard Odier, a Swiss private bank and asset manager. He led a group responsible for sustainable investment research, data science and analytics, product development, portfolio strategy and stewardship. Chris is an energy economist and economic geographer by training, a Visiting Business Fellow at the Smith School of Enterprise and the Environment at Oxford University, and a Fellow of the Royal Geographical Society. He received his PhD from Oxford University and masters from Columbia University (SIPA). |
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15:35-16:35 |
Panellists
Professor Paul FreemontImperial College London Professor Paul FreemontImperial College London Professor Paul Freemont is the co-founder of the Imperial College Centre for Synthetic Biology and Innovation and co-founder and co-director of the National UK Innovation and Knowledge Centre for Synthetic Biology (SynbiCITE - since 2013). His research is focused on developing automation and biofoundries and cell-free systems for specific synthetic biology applications. He is a council member of the US Engineering Biology Research Consortium and co-chair of the newly formed UK Governments Engineering Biology Steering Group and sits on the UK Governments Biosecurity Leadership Council. He is a member of the World Economic Forum Global Future Council on Synthetic Biology and is currently leading a US-funded Task Force on Engineering Biology Metrics and Technical Standards for Global Bioeconomy. He is also co-founder and founding chair of the Global Biofoundry Alliance. He is a passionate advocate for the commercialisation of engineering biology and is co-founder of the Imperial spin-out Solena Materials Ltd developing designer protein fibres and also of SynBioVen Ltd, an early-stage seed investment company for engineering biology start-ups in the UK. Dr Jason MelladStart Codon Dr Jason MelladStart Codon Jason is a scientist and entrepreneur, passionate about translating innovative technologies into better patient outcomes. As CEO and Co-Founder of Start Codon, a UK-based accelerator, he aims to discover the most disruptive life science, BioTech and healthcare founders and help them translate their innovations into successful ventures. This is achieved through a combination of seed funding and a bespoke venture-building programme, which taps into the exceptional resources of the Cambridge cluster as well as the global network and knowledge of Jason and the Start Codon team. Previously, he was CEO of Cambridge Epigenetix (now Biomodal) and Business Development Manager for Horizon Discovery’s diagnostics division. He also served as an associate for Cambridge Enterprise, the technology transfer office of the University of Cambridge. Jason had completed his PhD in Medicine at the University of Cambridge and is also a visiting Fellow at Jesus College, Cambridge, and lives in Cambridge with his husband and sons. Dr Mark RenshawDepartment for Science, Innovation and Technology Dr Mark RenshawDepartment for Science, Innovation and Technology Mark leads on key elements of the growth agenda for engineering biology in the Department for Science, Innovation and Technology. He has worked across R&D funding, infrastructure, regulation and standards, talent and skills and business finance for engineering biology since 2021. A civil servant who has a career focus on science and technology policy, prior to this role he worked on ‘deep tech’ innovation, on EU Exit, on the establishment of UK Research & Innovation, and on the Newton Fund. He has a PhD in Experimental Psychology from the University of Cambridge. Dr Fabrizio Ticchiarelli-MarjotARIA Dr Fabrizio Ticchiarelli-MarjotARIA I am a Technical Specialist at ARIA where I am responsible for evaluating proposals and providing recommendations to fund projects as part of our Opportunity space on Programmable Plants. I also work in an advisory capacity with the teams we fund to ensure timely technical delivery and good sharing of knowledge within the communities we help create. I have experience working in software/hardware biotech startups in the agricultural and medical sectors - first at Synthace, a software company working on empowering scientist to optimise experimental design and easily use automation; and more recently at Gardin, a hardware/software company developing a low cost insight platform to optimise production in controlled environment agriculture, where I headed the Plant Science R&D department and was part of the founding leadership team. I hold a PhD in Plant Science from Cambridge, and joint degrees in biotechnology from the University of Pisa and the Sant’Anna School of Advanced Studies, and my specialties include plant science, molecular biology, genetics and synbio. Dr Rowan McKibbinBBSRC Dr Rowan McKibbinBBSRC |
16:35-16:45 |
Reflections
Professor Dame Angela McLeanUniversity of Oxford Professor Dame Angela McLeanUniversity of Oxford Angela McLean is a mathematical biologist at Oxford University where she is a Senior Research Fellow at All Souls College and Professor of Mathematical Biology in the Zoology Department. Her research interests concern understanding how fast infections spread, both within individuals and between individuals. In addition to her own academic work she has played a sustained role in advising government on the use of scientific evidence in making good policies. At the Royal Society she Co-Chairs the Data Community of Interest and Chairs the steering group for the series of public lectures on artificial intelligence, You and AI. |
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16:45-16:50 |
Closing remarks
Dr Damian KellyCroda Dr Damian KellyCroda Damian holds a BSc in Chemistry, MSc in Surface Science & Catalysis and a PhD in Tribology from the University of Cambridge. Upon graduation Damian joined the Croda Graduate Development Programme in 2001. Over the past 16 years Damian has held several positions across different Croda markets, divisions and functions including Personal Care Sales Manager for Latin America, Performance Technologies Business Development Manager for North America and Life Sciences Vice President for Europe with both Technical and Commercial responsibility. Damian is presently Head of Global Research & Development for all Croda sectors, based at Croda’s manufacturing site in Widnes, Cheshire. Damian is also the technical lead for Croda’s Technology Investment Group which is responsible for the acquisition and licensing of new technologies that match the needs of all Croda’s end markets. |