Engineering biology

14 January 2025 09:30 - 17:00 Online Free Watch online

Exploring what is needed to realise the full potential of the UK's engineering biology sector.

Engineering biology refers to the use of specialist tools and technologies to produce biology-derived processes and products, which are often more sustainably produced than their existing counterparts. Engineering biology is one of five critical technologies identified by the Department for Science, Innovation and Technology (DSIT) as areas where the UK is in an excellent position to lead the world. 

However, as this field continues to rapidly advance, it is vital that we are able to translate and apply ground-breaking research into commercial settings through innovation that is trustworthy and responsible.

This conference will explore the translation journey of new technology from the laboratory to the market, how responsible innovation can be facilitated, what is needed to improve UK infrastructure as well as what funding mechanisms could be employed to realise the full potential of these innovations.

Transforming our future conferences

This conference forms part of the Royal Society's industry-focused Transforming our future series. These unique meetings feature cutting-edge science and bring together experts from industry, academia and government to explore and address key scientific and technical challenges of the coming decade.

Organisers

  • Dr Damian Kelly

    Dr Damian Kelly

    Damian holds a BSc in Chemistry, MSc in Surface Science & Catalysis and a PhD in Tribology from the University of Cambridge. Upon graduation Damian joined the Croda Graduate Development Programme in 2001. Over the past 23 years Damian has held several positions across different Croda markets, divisions and functions including Personal Care Sales Manager for Latin America, Performance Technologies Business Development Manager for North America and Life Sciences Vice President for Europe with both Technical and Commercial responsibility. Damian is presently Vice President Innovation & Technology Development for all Croda businesses globally and has responsibility for the acquisition and licensing of new technologies that match the needs of all Croda’s end markets.

  • Professor Anne Osbourn

    Professor Anne Osbourn

    Anne Osbourn is a Group Leader at the John Innes Centre working on plant natural products. Her discovery that in plant genomes the genes needed to make particular natural products are often organised in clusters like ‘beads on a string’ has greatly accelerated the discovery of new pathways and chemistries.  She has established a synthetic biology platform based on transient plant expression that provides rapid access to previously inaccessible compounds at gram scale. These two step changes open up new routes to combine genomics and synthetic biology to synthesize and access previously inaccessible natural products and analogs for medicinal, agricultural and industrial applications.  Anne was awarded the Novozymes 2023 Award in recognition of her scientific contributions.  She is also a poet, and has developed and co-ordinates the Science, Art and Writing (SAW) Initiative (www.sawtrust.org), a cross-curricular science education outreach programme. Her prize-winning poetry collection ‘Mock Orange’ was published in 2020.

  • Dr David Tew

    Dr David Tew

    David Tew is a Senior Scientific Director at GSK.  David has 35 years of experience in the pharmaceutical industry including early drug discovery, mechanistic enzymology, assay development, reagent generation and the application of Synthetic Biology.  Most recently David has been leading a project to apply Synthetic Biology to redesign the manufacture of therapeutic oligonucleotides.  This has resulted in a platform approach to therapeutic oligonucleotide synthesis and manufacture that is both scalable and more sustainable than current approaches.  

    David held a position as The Royal Society Entrepreneur in Residence at Bristol University working with BrisSynBio and the Bristol Biodesign Institute from 2018 to 2022.
    During the SARS-CoV-2 pandemic, David lead the innovation workstream for the Cambridge COVID-19 Testing Centre, a collaboration between AstraZeneca, GlaxoSmithKline and the University of Cambridge.

Schedule

09:30-09:40 Welcome and opening remarks
Sir David Baulcombe

Sir David Baulcombe

Cambridge University

Professor Martin Dawson FRS

Professor Martin Dawson FRS

University of Strathclyde

09:40-10:05 Opening keynote

In terrestrial life, DNA is copied to messenger RNA, and the 64 triplet codons in messenger RNAs are decoded – in the process of translation – to synthesize proteins. Cellular protein translation provides the ultimate paradigm for the synthesis of long polymers of defined sequence and composition, but is commonly limited to polymerizing the 20 canonical amino acids. I will describe our progress towards the encoded synthesis of non-canonical biopolymers. These advances may form a basis for new classes of genetically encoded polymeric materials and medicines. To realize our goals we are re-imagining some of the most conserved features of the cell; we have created new ribosomes, new aminoacyl-tRNA synthetase/tRNA pairs, and organisms with entirely synthetic genomes in which we have re-written the genetic code.

Professor Jason Chin

Professor Jason Chin

MRC Laboratory of Molecular Biology

Chair

Dr David Tew

Dr David Tew

GSK

10:05-10:10 Introduction to Session 1
Dr David Tew

Dr David Tew

GSK

10:10-10:25 Recoding Regulation. Towards predictable engineering of quantitative traits

Genetic technologies can be used to enhance crops and promote sustainable agriculture. However, the manipulation of traits governed by multiple genes can be challenging. Plant responses to the environment, including to biotic and abiotic stressors, are often controlled by multiple genes, coordinated by complex regulatory networks. Recent advances in genomics and computational modelling allow dynamic responses to environmental perturbations to be measured and the underlying networks inferred. Although these networks identify candidate regulators associated with traits, the effects of genetic manipulation, particularly given network topologies such as feedforward and feedback loops, are non-intuitive and difficult to predict. We combine systems biology and computational modelling to predict the impacts of network perturbations/re-wiring. We test their impact using gene editing and synthetic genetic controllers, with the aim of providing strategies for the predictable engineering of agricultural traits.

Dr Nicola Patron

Dr Nicola Patron

University of Cambridge

10:25-10:40 From lab to scale: insights from the Colorifix journey

Colorifix is a UK-based synthetic biology company that has developed a biological process to produce, deposit and fix colorants onto materials. Compared to incumbent dyeing solutions, Colorifix’s patented technology leads to significant reductions in energy and water usage, as well as the avoidance of harmful chemicals. It began as a University of Cambridge spin-out and has since raised over £40m in investor funding. The company has several active customers across Europe and has been primarily focused on serving manufacturers working with leading fashion brands, followed by more recent partnerships in cosmetics and homewares. Colorifix has a semi-distributed scaling model. The team engineers colour-producing micro-organisms, but then rather than fermenting them in centralised production facilities, proprietary bioreactors are installed on customer sites and Colorifix provides training to run the fermentation process in the dye house. This approach aims to maximise environmental savings and accelerate the path to cost parity.

Christopher Hunter

Christopher Hunter

Colorifix

10:40-10:55 The role of IP in real-world impact

Academics, investors, policy makers and regulators all need to know - what are the emerging opportunities? Where to invest?  What to fund?  What regulations will we need?

Although patent protection is just one form of intellectual property, it is crucial for innovative engineering biology companies to bring their products to market, and analysing the patent landscape gives a lot of information as to who is doing what, and where.

Potter Clarkson is launching results of an in-depth, bespoke study with Inevus Advanced Analytics Ltd, exploring patents in engineering biology published at the European Patent Office (EPO) from 2004 to 2023, using advanced analytics, including natural language processing (NLP) and topic modeling.

Patenting in the engineering biology space is experiencing rapid growth, powered by diverse applications including therapeutics, biomanufacturing, biofuels and much more, with the UK ranked 5th in the world by relative specialisation index.

Dr Sara Holland

Dr Sara Holland

Potter Clarkson LLP

10:55-11:05 Q&A

Chair

Professor Anne Osbourn

Professor Anne Osbourn

John Innes Centre

11:35-11:40 Introduction to Session 2
Professor Anne Osbourn

Professor Anne Osbourn

John Innes Centre

11:40-11:55 Creating a meeting place for science and society

Scientific discovery and innovation offer enormous opportunities to improve people’s lives  and look after our planet.  However, for societies to realise the benefits of any advances, people need to be accepting of new technologies and so there needs to be trust. Scientists are the general public and represent diverse cross-sections of society, so who better to engage with communities to improve understanding of scientific processes and goals.  The SAW Trust provides training for scientists to develop skills to explore research topics with non-scientists and creates opportunities for people to reflect and respond to science through poetry and visual arts.

Dr Jenni Rant

Dr Jenni Rant

SAW Trust / John Innes Centre

11:55-12:10 Delivering Pro-Innovation Regulation for Engineering Biology

The UK Pro-Innovation Regulation of Technologies Review on Life Sciences, led by Dame Angela McLean, published in 2023, included a section on Engineering Biology (EB) that pointed to the difficulties faced by novel technologies in fitting into current legislative boundaries. Following from that, as part of the DSIT ‘Sector Vision’, the Regulatory Horizons Council was commissioned to review the regulation of engineering biology sectors and the report, to be published in December 2024, considers what pro-innovation regulation would mean for Engineering Biology sectors and how it could be delivered. This talk will summarise the conclusions and recommendations of the RHC report and will speculate on future developments in the governance / regulation of engineering biology.

Professor Joyce Tait

Professor Joyce Tait

University of Edinburgh

12:10-12:25 Developing ethically sensitive governance for trustworthy and inclusive innovation

Engineering biology brings new and old ethical questions into focus, and exploring these requires considered, rigorous and persistent ethical analyses at all stages of innovation.  Focussing on health-related developments, this presentation will, firstly, outline some of the pressing ethical concerns, from big picture issues relating to desirable futures, to the pragmatics of research practice.   Secondly, we will consider how deliberation, involving publics and a range of stakeholders, is essential to ensuring trustworthy governance that is inclusive, proportionate and agile.  In this way, ethical challenges can be addressed and embedded in regulatory frameworks.

Professor Sarah Cunningham-Burley

Professor Sarah Cunningham-Burley

Nuffield Council on Bioethics & University of Edinburgh

12:25-12:35 Q&A

Chair

Dr Damian Kelly

Dr Damian Kelly

Croda

13:35-13:40 Introduction to Session 3
Dr Damian Kelly

Dr Damian Kelly

Croda

13:40-13:55 Addressing the Challenges of Bio-Manufacturing: A Path to Sustainable and Cost-Effective Production of Industrial Chemicals and Fuels

The need for disruptive technologies to overcome the high capital and operational costs in large-scale bio-manufacturing of industrial chemicals and fuels, while enhancing process resilience, remains a critical challenge. Engineering Biology has shown considerable promise, but it has yet to deliver production platforms that are cost-competitive with traditional manufacturing methods at scale. In response, C3 Biotech is pioneering a novel platform that enables on-site production of "programmable fuels" and industrial chemicals from waste biomass/CO₂. This platform eliminates the need for sterilisation of equipment and feedstocks, providing a more energy-efficient and sustainable manufacturing solution.

Continuous, non-sterile production has been demonstrated. Modular, industrial-scale systems are now being developed for scalability and transportability with substantial reductions in capital/operational expenditure. This will position bio-manufacturing of chemicals as a near-term commercial reality to secure UK supply chains for critical chemicals/fuels and support the nation’s net-zero goals for chemicals/fuels production.

Professor Nigel S. Scrutton

Professor Nigel S. Scrutton

University of Manchester

13:55-14:10 Engineering Biology’s Future: The Startup Perspective on Growth and Challenges

Startups are essential to unlocking the full potential of engineering biology in the UK, driving innovation, growth, and solutions to critical challenges in sustainability. But what’s holding them back? This session explores how startups can accelerate the translation of groundbreaking research into impactful, commercially viable solutions.

Drawing on success stories and lessons from the field, it highlights the role of startups in advancing innovation and delivering global impact—and the infrastructure, support, and funding needed to help them thrive. One startup's reflections on what’s needed to build a stronger ecosystem and cement the UK’s leadership in engineering biology.

Zoe Woods

Zoe Woods

Change Bio

14:10-14:25 Industrialising Synthetic Biology: Lessons from pharma

Large molecule pharmaceuticals are discovered and manufactured using engineering biology and account for 80% of the world’s top selling pharmaceuticals and vaccines. Most small molecule pharmaceuticals are either existing natural products or are constructed using medicinal chemistry.  Engineering biology is used to make bespoke enzyme catalysts to simplify and improve the sustainability of chemical processes. There are few examples of synthetic biology being used in small molecule manufacture beyond metabolic engineering of the natural hosts or making common natural molecules in new hosts.

The key challenge is creation of a pipeline of new products discovered using engineering biology as opposed to changing processes in development. For a change process to be viable the principle obstacle to target is the time taken converting a hit into a viable process.

Ted Chapman

Ted Chapman

Retired, Previously Director Biotechnology Development GSK

14:25-14:40 A perspective from the agriculture industry

Syngenta is a leading global agricultural life sciences company, providing technologies to farmers around the world to enable them to grow food productively and sustainably. An increasing demand for sustainable crop protection and nutrition, driven by regulatory, society and value chain pressures are providing exciting opportunities for biological based innovation (e.g. microbes, extracts, proteins, natural products etc.).  Differing significantly from conventional chemical products, these technologies require engineering biology tools to manipulate and edit microbes for rapid optimisation and the development of bioprocesses. We believe that to successfully scale and bring biological crop protection technologies to global markets will require key engineering biology platforms, infrastructure and skills to be drawn together around this thematic area.

Dr Robert Harris

Dr Robert Harris

Syngenta

14:40-14:55 Q&A

Chair

Dr Christopher Kaminker

Dr Christopher Kaminker

BlackRock Investment Institute (BII)

15:25-15:35 Introduction to panel
Dr Christopher Kaminker

Dr Christopher Kaminker

BlackRock Investment Institute (BII)

15:35-16:35 Panellists
Professor Paul Freemont

Professor Paul Freemont

Imperial College London

Dr Jason Mellad

Dr Jason Mellad

Start Codon

Dr Mark Renshaw

Dr Mark Renshaw

Department for Science, Innovation and Technology

Dr Fabrizio Ticchiarelli-Marjot

Dr Fabrizio Ticchiarelli-Marjot

ARIA

Dr Rowan McKibbin

Dr Rowan McKibbin

BBSRC

16:35-16:45 Reflections
Professor Dame Angela McLean FRS

Professor Dame Angela McLean FRS

University of Oxford

16:45-16:50 Closing remarks
Dr Damian Kelly

Dr Damian Kelly

Croda