Cyborg futures - the challenge of implanting and integrating artificial muscle

09 - 10 June 2025 09:00 - 17:00 The Royal Society Free Watch online
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Discussion meeting organised by Professor Jonathan Rossiter, Dr Nazia Mehrban, Professor Martin Birchall, Dr Majid Taghavi, Professor Dario Farina, Dame Molly Stevens FRS FREng, and Dr Elefteria Iliadou.

This meeting will be the first to address the scientific and social challenges of cyber-physical enhancement, robotic body restoration and implantable artificial muscles. The event brings together world-leading researchers and innovators to explore a cyborg future, with leading presentations and deep discussions in smart materials, implantable artificial muscles, neurointerfacing, soft robots, surgical implantation, bioninterfaces, biomaterials, ethics and more!

Programme

The programme, including speaker biographies and abstracts, will be available soon. Please note the programme may be subject to change.

Poster session

There will be a poster session from 17:00 on Monday 9 June 2025. If you would like to present a poster, please submit your proposed title, abstract (up to 200 words), author list, and the name of the proposed presenter and institution no later than 11 May 2025.

Attending the event

This event is intended for researchers in relevant fields

  • Free to attend
  • Both virtual and in-person attendance is available. Advance registration is essential. Please follow the link to register.
  • Lunch is available on both days of the meeting for an optional £25 per day. There are plenty of places to eat nearby if you would prefer purchase food offsite. Participants are welcome to bring their own lunch to the meeting.

Enquiries: Scientific Programmes team.

Image credit: ©️iStock/ChrisChrisW

Schedule

Chair

Professor Wenhui Song, University College London, UK

Professor Wenhui Song

University College London, UK

11:45-12:30 Panel discussion
09:00-09:05 Welcome by the Royal Society and lead organiser
09:05-09:15 Cyborg futures - engineering implantable artificial muscles

A future where people with disabilities and older people are restored to mobility and health through implantable muscles is very attractive, but faces huge challenges in technology, implantation, control and acceptance. Here we will review the latest progress in fundamental artificial muscle technologies for function restoration developed on the emPOWER project and at the University of Bristol's SoftLab. These include field-driven electrogels, liquid-metal self-oscillating fluid networks and functional hydrogels.

Professor Jonathan Rossiter

Professor Jonathan Rossiter

University of Bristol, UK

09:15-09:45 Title to be confirmed
09:45-10:15 From heart pump to face reconstruction: success and challenges in soft actuator implants

Whenever something moves in the human body, our muscles do the work. However, while today it part of everyday clinical practice to replace joints and bones with artificial parts, reconstruction medicine still has great difficulties finding a suitable replacement for damaged or destroyed muscles. There is one muscle in particular whose function is vital and is the subject of several studies, but without convincing results: the heart. Other muscles of the body actually share mechanical similarities with the heart, including the urinal sphincter muscle, which, if damaged, can cause urinary incontinence. Facial muscles also share such similarities and must be replaced after an accident or injury. Although these muscles do not play a vital role in the body, they remain extremely important for patients' quality of life, for example a well-functioning sphincter muscle is critical in order to avoid unpleasant side effects such as needing to wear diapers. The parallels between muscle types could allow the development of universal electroactive multifunctional actuators. Within the Centre for Artificial Muscles (CAM), EPFL, in cooperation with its partners in heart surgery, face reconstruction and urology - University of Bern and Reconstructive Medicine - University of Zürich, aims to become the world's leading reference for the development and clinical transfer of a brand new technological approach for artificial muscles in the human body. The proposed keynote intends to show some examples realised in this new centre.

Dr Yves Perriard

Dr Yves Perriard

École Polytechnique Fédérale de Lausanne, Switzerland

10:15-10:45 Title to be confirmed
Professor Shoji Takeuchi

Professor Shoji Takeuchi

University of Tokyo, Japan

10:45-11:15 Break
11:15-11:45 Soft microfabricated electrodes: expanding possibilities in neuroprosthetics and neural research (online)

Soft microfabricated electrodes are unlocking new possibilities in neural engineering by providing adaptable, biocompatible interfaces that seamlessly integrate with biological tissues. This talk explores recent advancements in these electrodes, focusing on two key applications: auditory prostheses and brain organoid research. In auditory systems, soft, multichannel implants are especially suited for conforming to the complex, curved surface of the cochlear nucleus, enabling precise simulation for patients who are not candidates for traditional cochlear implants. In brain organoid research, innovative electrode designs such as stretchable MEAs and the self-actuating "e-Flower" electrode provide high-resolution recordings of neural activity, even under mechanical strain. These applications highlight the transformative potential of soft electrodes to bridge the gap between engineered devices and complex neural systems, advancing both clinical therapies and fundamental neuroscience.

Stéphanie Lacour

Stéphanie Lacour

École Polytechnique Fédérale de Lausanne

Chair

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Dr Nazia Mehrban

University of Bath, UK

13:30-13:45 Title to be confirmed
13:45-14:15 Title to be confirmed
Dr Ben Metcalfe

Dr Ben Metcalfe

University of Bath

14:15-14:45 Title to be confirmed
Professor Tamar Makin

Professor Tamar Makin

University of Cambridge, UK

14:45-15:15 Title to be confirmed
Professor Vivian Mushahwar FAIMBE FCAHS

Professor Vivian Mushahwar FAIMBE FCAHS

University of Alberta, Canada

15:15-15:45 Break
15:45-16:15 Muscles to embody uncertainty, optimally interact with the environment and enhance sensory extraction

In this talk, I will present how humans control their muscles to interact optimally with their environment and how implementing these principles can create versatile artificial muscle systems. Human muscles function as soft actuators with tunable spring-like properties, allowing for adaptive energy exchange, maximal sensory extraction, and compensation for stable, unstable, or uncertain dynamics. By modelling and implementing these adaptive mechanisms, we have developed robotic systems that advance flexible industrial automation, teleoperation, and intuitive, efficient human-robot interaction.

Professor Etienne Burdet

Professor Etienne Burdet

University College London, UK

16:15-17:00 Panel discussion
Dr Martin Garrard

Dr Martin Garrard

University of Bristol, UK

17:00-18:15 Poster session

Chair

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Dr Nazia Mehrban

University of Bath, UK

09:00-09:15 Title to be confirmed
09:15-09:45 Biologic interactions of biosynthetic scaffolds composed of poly 4-hydroxy butyrate

The purpose of the talk is to provide an overview on how polymeric biomaterials, and particularly their degradations products, elicit differential responses by the immune cells at the biomaterial-tissue interface. Focusing on the biosynthetic surgical mesh composed of poly (4-hydroxybutyrate) (P4HB), a biomaterial widely used in the biomedical field for hernia repair applications, which has been associated with improved long-term remodelling response and decreased surgical site infection in pre-clinical and clinical studies. In our research, we have identified that 4-hydroxybutyrate (4HB), the main degradation product of P4HB and a short chain fatty acid (SCFA), endogenously secreted in the body, promotes a pro-remodelling, regulatory phenotype of macrophages, which partially contribute to the promotion of site appropriate tissue remodelling. Moreover, through our research it was found that 4HB increased the expression of antimicrobial peptides (AMP) in these macrophages. These studies provided insights on the associated molecular mechanism. It was identified that the mechanisms of AMP secretion are independent of a direct HDAC inhibitory activity, commonly associated with SCFA. Instead, it involves the transcriptional activation of cathelicidin LL-37 through MAP-kinase and NF-KB pathways. Key proteins identified in the transcriptional activation process were GPR109a, JNK, P38, NF-KB, and AP-1. The results of this work expand the understanding of the biologic activity of 4HB in immune system cells and demonstrate its potential to promote a constructive tissue remodelling effect for regenerative medicine applications.

Professor Catalina Pineda Molina

Professor Catalina Pineda Molina

University of Pittsburgh, USA

09:45-10:15 Title to be confirmed
10:15-10:45 Advancing the biofabrication of tissue building blocks

The seamless integration of biological and engineered components is essential for ensuring the functionality of artificial muscles. Engineered tissues hold great promised in facilitating the integration. Functional tissue building blocks, in particular, will allow the introduction of multiple functionalities into engineered tissues, further enhancing the integration of both biological and engineering components.

Our research focuses on developing innovative biofabrication strategies to create functional tissue building blocks and exploring their potential to support the functionality of engineered tissues.

In this presentation, I will present our work on microfluidic platforms for generating microvessel templates that guide a vascular integration within engineered tissues both in vitro and in vivo. Additionally, I will discuss how we leverage 3D printing, combined with magnetic control to fabricate thin-layered bioscaffolds and how these bioscaffolds facilitate the creation of 3D vascular networks and 3D biohybrid actuators. Furthermore, I will talk about the generation of magnetically responsive, cell-laden microgels with smart assembly and motion abilities and discuss their potential for dynamic, minimally invasive tissue delivery and interfacing.

We believe these biofabricated building blocks provide promising strategies in supporting the implantation, (neuro)vascular integration, and muscular control capabilities of engineered tissues, and will contributed to the development of functional systems for enhanced muscular restoration.

Dr Ruoxiao Lie

Dr Ruoxiao Lie

University of Liverpool, UK

10:45-11:15 Break
11:15-11:45 Title to be confirmed
Professor Alicia El Haj FREng

Professor Alicia El Haj FREng

University of Birmingham, UK

11:45-12:30 Panel discussion
Dr Majid Taghavi

Dr Majid Taghavi

Imperial College London, UK

13:30-13:45 Title to be confirmed
Professor Martin Birchall FMedSci

Professor Martin Birchall FMedSci

University College London, UK

13:45-14:15 Title to be confirmed
14:15-14:45 Title to be confirmed
14:45-15:15 Title to be confirmed
Dr Avril McCarthy

Dr Avril McCarthy

Sheffield Teaching Hospitals NHS Foundation Trust, UK

15:15-15:45 Break
15:45-16:15 Title to be confirmed
Dr Dana Damian

Dr Dana Damian

University of Sheffield, UK

16:15-17:00 Panel discussion