May 27, 2010 - This article will provide an updated review of spermatogonial stem cells and their role in maintaining the spermatogenic lineage. Experimental tools used to study spermatogonial stem cells (SSCs) will be described, along with…

Bart T. Phillips, Kathrin Gassei, Kyle E. Orwig

Oct 19, 2015 - Human pluripotent stem cells can in principle be used as a source of any differentiated cell type for disease modelling, drug screening, toxicology testing or cell replacement therapy. Type I diabetes is considered a major target…

Maria Rostovskaya, Nicholas Bredenkamp, Austin Smith

Jun 6, 2018 - There is urgent need to improve the clinical outcome of peripheral nerve injury. Many efforts are directed towards the fabrication of bioengineered conduits, which could deliver stem cells to the site of injury to promote and guide peripheral nerve

Andrea Francesco Verre, Alessandro Faroni, Maria Iliut, Claudio Silva, Cristopher Muryn, Adam J. Reid, Aravind Vijayaraghavan

May 6, 2014 - In the adult hippocampus, neurogenesis—the process of generating mature granule cells from adult neural stem cells—occurs throughout the entire lifetime. In order to investigate the involved regulatory mechanisms, knockout (KO) experiments,

Frederik Ziebell, Ana Martin-Villalba, Anna Marciniak-Czochra

Jan 12, 2010 - In recent years, there has been an explosion of interest in stem cells, not just within the scientific and medical communities but also among politicians, religious groups and ethicists. Here, we summarize the different types of stem…

Fiona M. Watt, Ryan R. Driskell

Jul 5, 2018 - Bone has many functions. It is responsible for protecting the underlying soft organs, it allows locomotion, houses the bone marrow and stores minerals such as calcium and phosphate. Upon damage, bone tissue can efficiently repair itself. However,

Wai Long Tam, Frank P. Luyten, Scott J. Roberts

Jul 5, 2018 - Over the past few decades, a variety of different reagents for stem cell maintenance and differentiation have been commercialized. These reagents share a common goal in facilitating the manufacture of products suitable for cell therapy while

Louise Hagbard, Katherine Cameron, Paul August, Christopher Penton, Malin Parmar, David C. Hay, Therése Kallur

Feb 23, 2007 - Neurogenesis persists in two germinal regions in the adult mammalian brain, the subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal formation. Within these two neurogenic niches, specialized astrocytes are

Patricio A Riquelme, Elodie Drapeau, Fiona Doetsch

Dec 23, 2020 - A recent hypothesis proposed that the total number of stem cell divisions in a tissue (TSCD model) determine its intrinsic cancer risk; however, a different model—the multistage model—has long been used to understand how cancer originates.

Leonard Nunney, Kevin Thai