Dec 6, 2010 - The use of stem cells for regenerative medicine has captured the imagination of the public, with media attention contributing to rising expectations of clinical benefits. Human embryonic stem cells (hESCs) are the best model for…

Emma Stephenson, Caroline Mackie Ogilvie, Heema Patel, Glenda Cornwell, Laureen Jacquet, Neli Kadeva, Peter Braude, Dusko Ilic

Aug 6, 2013 - The temporomandibular joint (TMJ) disc lacks functional replacement after discectomy. We investigated tissue-engineered bilayer polylactide (PLA) discs and autologous adipose stem cells (ASCs) as a potential replacement for the TMJ disc. These ASC

Katja Ahtiainen, Jari Mauno, Ville Ellä, Jaana Hagström, Christian Lindqvist, Susanna Miettinen, Timo Ylikomi, Minna Kellomäki, Riitta Seppänen

Mar 18, 2008 - The surface microtexture of an orthopaedic device can regulate cellular adhesion, a process fundamental in the initiation of osteoinduction and osteogenesis. Advances in fabrication techniques have evolved to include the field of surface modification

M.J.P Biggs, R.G Richards, S McFarlane, C.D.W Wilkinson, R.O.C Oreffo, M.J Dalby

Aug 31, 2016 - Three-dimensional (3D) computational tissue models can provide a comprehensive description of tissue dynamics at the molecular, cellular and tissue level. Moreover, they can support the development of hypotheses about cellular interactions and about

Torsten Thalheim, Peter Buske, Jens Przybilla, Karen Rother, Markus Loeffler, Joerg Galle

Aug 29, 1999 - Although neural transplantation has made a relatively successful transition from the animal laboratory to human neurosurgery for the treatment of Parkinson's disease, the use of human embryonic brain tissue as the source of transplants raises

Jeffrey A. Gray, Helen Hodges, John Sinden

Dec 6, 2009 - Ataxia-telangiectasia mutated (ATM) is known to play a central role in effecting the DNA damage response that protects somatic cells from potentially harmful mutations, and in this role it is a key anti-cancer agent. However, it also promotes repair

Robert G. Clyde, Ashley L. Craig, Lucas de Breed, James L. Bown, Leslie Forrester, Borivoj Vojtesek, Graeme Smith, Ted Hupp, John Crawford

Mar 28, 2008 - How can planarians regenerate their brain? Recently we have identified many genes critical for this process. Brain regeneration can be divided into five steps: (1) anterior blastema formation, (2) brain rudiment formation, (3) pattern formation, (4)

Kiyokazu Agata, Yoshihiko Umesono

Jun 6, 2011 - There has been a growing interest in using biofunctionalized magnetic particles for cell isolation. This paper describes the synthesis and characterization of magnetite-polymer (Fe3O4-poly-ɛ-caprolactone, magnetite-PCL) microparticles surface

Elizabeth R. Balmayor, Iva Pashkuleva, Ana M. Frias, Helena S. Azevedo, Rui L. Reis

Dec 5, 2006 - Advanced therapies combating acute and chronic skin wounds are likely to be brought about using our knowledge of regenerative medicine coupled with appropriately tissue-engineered skin substitutes. At the present time, there are no models of an

Anthony D Metcalfe, Mark W.J Ferguson