Jun 28, 2019 - Low-intensity electric fields can induce changes in cell differentiation and cytoskeletal stresses that facilitate manipulation of osteoblasts and mesenchymal stem cells; however, the application times (tens of minutes) are of the order of

Ram Anand Vadlamani, Yaohui Nie, David A. Detwiler, Agni Dhanabal, Alan M. Kraft, Shihuan Kuang, Timothy P. Gavin, Allen L. Garner

Apr 6, 2020 - As the field of tissue engineering continues to advance rapidly, so too does the complexity of cell culture techniques used to generate in vitro tissue constructs, with the overall aim of mimicking the in vivo microenvironment. This complexity

H. W. Hoyle, L. A. Smith, R. J. Williams, S. A. Przyborski

Dec 5, 2022 - The founder cells of the gametes are primordial germ cells (PGCs). In mammals, PGCs are specified early during embryonic development, at the boundary between embryonic and extraembryonic tissue, long before their later residences, the gonads, have

Bernard A. J. Roelen, Susana M. Chuva de Sousa Lopes

Nov 5, 2017 - Already during early embryogenesis, before sex-specific hormone production is initiated, sex differences in embryonic development have been observed in several mammalian species. Typically, female embryos develop more slowly than their male siblings.

Edda G. Schulz

Jul 5, 2018 - Recent advances in the isolation of tissue-resident adult stem cells and the identification of inductive factors that efficiently direct differentiation of human pluripotent stem cells along specific lineages have facilitated the…

Sharmin Alhaque, Michael Themis, Hassan Rashidi

Mar 30, 2020 - Thousands of unfixed transposable element (TE) insertions segregate in the human population, but little is known about their impact on genome function. Recently, a few studies associated unfixed TE insertions to mRNA levels of adjacent genes, but

Clément Goubert, Nicolas Arce Zevallos, Cédric Feschotte

May 31, 2016 - The use of skeletal stem cells (SSCs) for cell-based therapies is currently one of the most promising areas for skeletal disease treatment and skeletal tissue repair. The ability for controlled modification of SSCs could provide significant

Catarina Costa Moura, Rahul S. Tare, Richard O. C. Oreffo, Sumeet Mahajan

Feb 5, 2015 - Anchorage-dependent cells are of great interest for various biotechnological applications. (i) They represent a formidable production means of viruses for vaccination purposes at very large scales (in 1000–6000 l reactors) using microcarriers, and

Otto-Wilhelm Merten

Aug 12, 2011 - Stem cells are defined by the simultaneous possession of the seemingly incongruent properties of self-renewal and multi-lineage differentiation potential. To maintain a stem cell population, these opposing forces must be balanced.…

Rodrigo Osorno, Ian Chambers