Jun 29, 1998 - The ability to process damaged DNA may vary between cells depending on their differentiated status. However, there is little in vivo data available and it is not intuitively obvious how the activity of specific repair pathways may vary between

Douglas J. Winton, Roger A. Brooks

Jul 26, 2019 - Cancer develops from mutated cells in normal tissues. Whether somatic mutations alter normal cell dynamics is key to understanding cancer risk and guiding interventions to reduce it. An analysis of the first incomplete moment of size distributions

Michael W. J. Hall, Philip H. Jones, Benjamin A. Hall

Jun 22, 1989 - The bog mosses, Sphagnum, lack any obvious anatomical specialization inside the stem but have a well-developed system of water conduction in capillary spaces among pendent branches around the stem. It has hitherto been assumed that this was the main

Aug 31, 2018 - The intestinal epithelium is a single layer of cells which provides the first line of defence of the intestinal mucosa to bacterial infection. Cohesion of this physical barrier is supported by renewal of epithelial stem cells, residing in

Daniele Muraro, Aimee Parker, Laura Vaux, Sarah Filippi, Axel A. Almet, Alexander G. Fletcher, Alastair J. M. Watson, Carmen Pin, Philip K. Maini, Helen M. Byrne

Sep 5, 2014 - A strong correlation between centrosome age and fate has been reported in some stem cells and progenitors that divide asymmetrically. In some cases, such stereotyped centrosome behaviour is essential to endow stemness to only one of the two daughters

Jose Reina, Cayetano Gonzalez

Oct 5, 2017 - Nucleosome remodelling (NR) regulates transcription in an ATP-dependent manner, and influences gene expression required for development and cellular functions, including those involved in anti-cancer and anti-ageing processes. ATP-utilizing

Reiko Watanabe, Shin-ichiro Kanno, Amaneh Mohammadi Roushandeh, Ayako Ui, Akira Yasui

Sep 14, 2020 - Collective migration, the movement of groups in which individuals affect the behaviour of one another, occurs at practically every scale, from bacteria up to whole species' populations. Universal principles of collective movement can be applied at

Adam Shellard, Roberto Mayor

Oct 19, 2015 - The predominant view of embryonic development and cell differentiation has been that rigid and even irreversible epigenetic marks are laid down along the path of cell specialization ensuring the proper silencing of unrelated lineage programmes. This

Koji Tanabe, Daniel Haag, Marius Wernig

Jul 5, 2018 - A large body of data have accumulated that characterize the gene regulatory network of stem cells. Yet, a comprehensive and integrative understanding of this complex network is lacking. Network reverse engineering methods that use transcriptome data

Johannes Meisig, Nils Blüthgen

Mar 29, 2021 - In nervous systems, there are two main modes of transmission for the propagation of activity between cells. Synaptic transmission relies on close contact at chemical or electrical synapses while volume transmission is mediated by diffusible chemical

Gáspár Jékely