Dec 6, 2013 - Cellular differentiation, reprogramming and transdifferentiation are determined by underlying gene regulatory networks. Non-adiabatic regulation via slow binding/unbinding to the gene can be important in these cell fate decision-making processes.

Chunhe Li, Jin Wang

Aug 12, 2011 - There has been an immense interest in embryonic stem cells owing to their pluripotent property, which refers to the ability to differentiate into all cell types of an embryo. In the maintenance of this pluripotent nature, transcription factors play

Kun Xue, Jia-Hui Ng, Huck-Hui Ng

Jun 28, 2019 - We have developed a novel electro-osmotic microfluidic system to apply precisely controlled osmolarity gradients to cancer cells in micro-channels. We observed that albeit adhesion is not required for cells to migrate in such a confined

T. H. Hui, W. C. Cho, H. W. Fong, M. Yu, K. W. Kwan, K. C. Ngan, K. H. Wong, Y. Tan, S. Yao, H. Jiang, Z. Gu, Y. Lin

Sep 30, 2020 - Disease response and durability of remission are very heterogeneous in patients with acute myeloid leukaemia (AML). There is increasing evidence that the individual risk of early relapse can be predicted based on the initial treatment response.

H. Hoffmann, C. Thiede, I. Glauche, M. Bornhaeuser, I. Roeder

Jul 5, 2018 - Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in developed countries. An in vitro NAFLD model would permit mechanistic studies and enable high-throughput therapeutic screening. While hepatic cancer-derived cell

Marcus J. Lyall, Jessy Cartier, John P. Thomson, Kate Cameron, Jose Meseguer-Ripolles, Eoghan O'Duibhir, Dagmara Szkolnicka, Baltasar Lucendo Villarin, Yu Wang, Giovanny Rodriguez Blanco, Warwick B. Dunn, Richard R. Meehan, David C. Hay, Amanda J. Drake

May 13, 2020 - The cuticle of ecdysozoans (Panarthropoda, Scalidophora, Nematoida) is secreted by underlying epidermal cells and renewed via ecdysis. We explore here the relationship between epidermis and external cuticular ornament in stem-group scalidophorans

Deng Wang, Jean Vannier, Xiao-guang Yang, Jie Sun, Yi-fei Sun, Wen-jing Hao, Qing-qin Tang, Ping Liu, Jian Han

Jul 31, 2017 - Polydimethylsiloxane (PDMS) is widely used in dynamic biological microfluidic applications. As a highly hydrophobic material, native PDMS does not support cell attachment and culture, especially in dynamic conditions. Previous covalent coating

Joni Leivo, Sanni Virjula, Sari Vanhatupa, Kimmo Kartasalo, Joose Kreutzer, Susanna Miettinen, Pasi Kallio

Aug 16, 2005 - Immune self-tolerance is controlled by a subset of T lymphocytes that are regulatory (Treg) and epigenetically programmed to suppress auto-reactive immune effector cells in vivo. By extrapolation, donor-specific transplantation tolerance might be

Su M Metcalfe

Jun 24, 2020 - Human mesenchymal stromal cells (MSCs) are a leading cell therapy candidate for the treatment of immune and inflammatory diseases due to their potent regulation of immune cells. MSC expression of indoleamine-2,3-dioxygenase (IDO) upon interferon γ

Devlin T. Boyt, Lauren K. Boland, BurandAnthony J. Jr, Alex J. Brown, James A. Ankrum