231 - 240 of 656 results

Journal - Journal of The Royal Society Interface

Safety paradigm: genetic evaluation of therapeutic grade human embryonic stem cells

Dec 6, 2010 - The use of stem cells for regenerative medicine has captured the imagination of the public, with media attention contributing to rising expectations of clinical benefits. Human embryonic stem cells (hESCs) are the best model for…

Journal - Journal of The Royal Society Interface

Autologous adipose stem cells and polylactide discs in the replacement of the rabbit temporomandibular joint disc

Aug 6, 2013 - The temporomandibular joint (TMJ) disc lacks functional replacement after discectomy. We investigated tissue-engineered bilayer polylactide (PLA) discs and autologous adipose stem cells (ASCs) as a potential replacement for the TMJ disc. These ASC

Journal - Journal of The Royal Society Interface

Adhesion formation of primary human osteoblasts and the functional response of mesenchymal stem cells to 330 nm deep…

Mar 18, 2008 - The surface microtexture of an orthopaedic device can regulate cellular adhesion, a process fundamental in the initiation of osteoinduction and osteogenesis. Advances in fabrication techniques have evolved to include the field of surface modification

Journal - Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences

Prospects for the clinical application of neural transplantation with the use of conditionally immortalized…

Aug 29, 1999 - Although neural transplantation has made a relatively successful transition from the animal laboratory to human neurosurgery for the treatment of Parkinson's disease, the use of human embryonic brain tissue as the source of transplants raises

Journal - Journal of The Royal Society Interface

A novel ataxia-telangiectasia mutated autoregulatory feedback mechanism in murine embryonic stem cells

Dec 6, 2009 - Ataxia-telangiectasia mutated (ATM) is known to play a central role in effecting the DNA damage response that protects somatic cells from potentially harmful mutations, and in this role it is a key anti-cancer agent. However, it also promotes repair

Journal - Philosophical Transactions of the Royal Society B: Biological Sciences

Brain regeneration from pluripotent stem cells in planarian

Mar 28, 2008 - How can planarians regenerate their brain? Recently we have identified many genes critical for this process. Brain regeneration can be divided into five steps: (1) anterior blastema formation, (2) brain rudiment formation, (3) pattern formation, (4)

Journal - Journal of The Royal Society Interface

Synthesis and functionalization of superparamagnetic poly-ɛ-caprolactone microparticles for the selective isolation of…

Jun 6, 2011 - There has been a growing interest in using biofunctionalized magnetic particles for cell isolation. This paper describes the synthesis and characterization of magnetite-polymer (Fe3O4-poly-ɛ-caprolactone, magnetite-PCL) microparticles surface