Jan 5, 2013 - The differentiation and reprogramming of cells are accompanied by drastic changes in the epigenetic profiles of cells. Waddington's classical model clearly describes how differentiating cells acquire their cell identity as the…

Akira Watanabe, Yasuhiro Yamada, Shinya Yamanaka

Feb 23, 2007 - Cell therapy has been perceived as the main or ultimate goal of human embryonic stem (ES) cell research. Where are we now and how are we going to get there? There has been rapid success in devising in vitro protocols for differentiating human ES

Su-Chun Zhang, Xue-Jun Li, M Austin Johnson, Matthew T Pankratz

May 29, 2004 - The thesis advanced in this essay is that stem cells—particularly those in the nervous system—are components in a series of inborn ‘programs’ that not only ensure normal development, but persist throughout life so as to maintain homeostasis

Jaime Imitola, Kook In Park, Yang D. Teng, Sahar Nisim, Mahesh Lachyankar, Jitka Ourednik, Franz-Josef Mueller, Rene Yiou, Anthony Atala, Richard L. Sidman, Mark Tuszynski, Samia J. Khoury, Evan Y. Snyder

Feb 6, 2014 - Multi-potent adult mesenchymal stem cells (MSCs) derived from bone marrow have therapeutic potential for bone diseases and regenerative medicine. However, an intrinsic heterogeneity in their phenotype, which in turn results in various

Rebecca Medda, Arne Helth, Patrick Herre, Darius Pohl, Bernd Rellinghaus, Nadine Perschmann, Stefanie Neubauer, Horst Kessler, Steffen Oswald, Jürgen Eckert, Joachim P. Spatz, Annett Gebert, Elisabetta A. Cavalcanti-Adam

Apr 6, 2014 - The regulation of cell growth in animal tissues is a question of critical importance: most tissues contain different types of cells in interconversion and the fraction of each type has to be controlled in a precise way, by mechanisms that remain

E. Hannezo, J. Prost, J.-F. Joanny

Mar 28, 2008 - Neural stem cells (NSCs) possess the ability to self-renew and to differentiate along neuronal and glial lineages. These processes are defined by the dynamic interplay between extracellular cues including cytokine signalling and intracellular

Masakazu Namihira, Jun Kohyama, Masahiko Abematsu, Kinichi Nakashima

Mar 19, 2018 - Solid progress has occurred over the last decade in our understanding of the molecular genetic basis of neurodevelopmental disorders, and of schizophrenia and autism in particular. Although the genetic architecture of both disorders is far more

David St. Clair, Mandy Johnstone

Aug 12, 2011 - Induced pluripotent stem (iPS) cells have considerable promise as a novel tool for modelling human disease and for drug discovery. While the generation of disease-specific iPS cells has become routine, realizing the potential of iPS…

Gabsang Lee, Lorenz Studer