Mar 19, 2018 - Solid progress has occurred over the last decade in our understanding of the molecular genetic basis of neurodevelopmental disorders, and of schizophrenia and autism in particular. Although the genetic architecture of both disorders is far more

David St. Clair, Mandy Johnstone

Feb 5, 2007 - Multiple sclerosis is the most common potential cause of neurological disability in young adults. The disease has two distinct clinical phases, each reflecting a dominant role for separate pathological processes: inflammation drives activity during

Siddharthan Chandran, David Hunt, Alexis Joannides, Chao Zhao, Alastair Compston, Robin J.M Franklin

Aug 5, 2016 - In the central nervous system (CNS), during both brain and spinal cord development, purinergic and pyrimidinergic signalling molecules (ATP, UTP and adenosine) act synergistically with peptidic growth factors in regulating the synchronized

Davide Lecca, Marta Fumagalli, Stefania Ceruti, Maria P. Abbracchio

Jun 6, 2014 - Stem cells (SCs) perform the task of maintaining tissue homeostasis by both self-renewal and differentiation. While it has been argued that SCs divide asymmetrically, there is also evidence that SCs undergo symmetric division. Symmetric SC division

Daniel Sánchez-Taltavull, Tomás Alarcón

Dec 6, 2010 - Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the ability (i) to duplicate indefinitely while maintaining pluripotency and (ii) to differentiate into cell types of all three embryonic…

Nigel G. Kooreman, Joseph C. Wu

Aug 12, 2011 - Induced pluripotent stem cells (iPS cells) can be exploited for both research and clinical applications. The first part of this review seeks to provide an understanding of the financial drivers and key elements of a successful business strategy that

Catherine Prescott

Feb 5, 2007 -

Siddharthan Chandran, Maeve Caldwell, Nick Allen

Dec 6, 2010 - Foetal stem cells (FSCs) can be isolated during gestation from many different tissues such as blood, liver and bone marrow as well as from a variety of extraembryonic tissues such as amniotic fluid and placenta. Strong evidence suggests that these

Hassan Abdulrazzak, Dafni Moschidou, Gemma Jones, Pascale V. Guillot

Mar 6, 2013 - Individual mouse embryonic stem cells have been found to exhibit highly variable differentiation responses under the same environmental conditions. The noisy cyclic expression of Hes1 and its downstream genes are known to be responsible for this,

Marc Sturrock, Andreas Hellander, Anastasios Matzavinos, Mark A. J. Chaplain