Jul 5, 2018 - Stem cell-derived hepatocyte-like cells (HLCs) offer great opportunities for studies of host–pathogen interactions and tissue regeneration, as well as hepatotoxicity. To reliably predict the outcome of infection or to enhance graft survival, a

Lena Fischer, David C. Hay, Cliona O'Farrelly

Dec 5, 2014 - To date, many regulatory genes and signalling events coordinating mammalian development from blastocyst to gastrulation stages have been identified by mutational analyses and reverse-genetic approaches, typically on a gene-by-gene basis. More recent

David-Emlyn Parfitt, Michael M. Shen

Aug 12, 2011 - Recent advances in stem cell technology have generated enthusiasm for their potential to study and treat a diverse range of human disease. Pluripotent human stem cells for therapeutic use may, in principle, be obtained from two…

Craig J. Taylor, Eleanor M. Bolton, J. Andrew Bradley

Oct 6, 2009 - The presence of bone-marrow-derived stem cells was investigated in a wound-healing model where subcutaneously implanted cellulose sponges were used to induce granulation tissue formation. When cellulose was coated with hydroxyapatite (HA), the

Miretta Tommila, Anne Jokilammi, Perttu Terho, Timothy Wilson, Risto Penttinen, Erika Ekholm

Feb 19, 2007 - Drosophila neuroblasts are similar to mammalian neural stem cells in their ability to self-renew and to produce many different types of neurons and glial cells. In the past two decades, great advances have been made in understanding the molecular

Boris Egger, James M Chell, Andrea H Brand

Nov 25, 2008 - In recent years, the potential of stem cell research for tissue engineering-based therapies and regenerative medicine clinical applications has become well established. In 2006, Chung pioneered the first entire organ transplant using adult stem

Mark R Placzek, I-Ming Chung, Hugo M Macedo, Siti Ismail, Teresa Mortera Blanco, Mayasari Lim, Jae Min Cha, Iliana Fauzi, Yunyi Kang, David C.L Yeo, Chi Yip Joan Ma, Julia M Polak, Nicki Panoskaltsis, Athanasios Mantalaris

Jul 6, 2015 - Three-dimensional imaging of human stem cells using transmission soft X-ray tomography (SXT) is presented for the first time. Major organelle types—nuclei, nucleoli, mitochondria, lysosomes and vesicles—were discriminated at approximately 50 nm

J. C. Niclis, S. V. Murphy, D. Y. Parkinson, A. Zedan, A. H. Sathananthan, D. S. Cram, P. Heraud

Dec 7, 2011 - Mechanical stimulation is an essential factor affecting the metabolism of bone cells and their precursors. We hypothesized that vibration loading would stimulate differentiation of human adipose stem cells (hASCs) towards bone-forming…

Laura Tirkkonen, Heidi Halonen, Jari Hyttinen, Hannu Kuokkanen, Harri Sievänen, Anna-Maija Koivisto, Bettina Mannerström, George K. B. Sándor, Riitta Suuronen, Susanna Miettinen, Suvi Haimi

Feb 28, 2017 - Spheroids formed of mesenchymal stem cells (MSCs) exhibit increased cell survival and trophic factor secretion compared with dissociated MSCs, making them therapeutically advantageous for cell therapy. Presently, there is no…

Kaitlin C. Murphy, Ben P. Hung, Stephen Browne-Bourne, Dejie Zhou, Jessica Yeung, Damian C. Genetos, J. Kent Leach

Dec 4, 1984 - Recombinant genes can be introduced into the germ line of mice by microinjection into the fertilized egg or via embryonal carcinoma stem cells. A regulated, cell-type specific expression of the newly introduced gene following microinjection is