Jul 6, 2011 - Three-dimensional gel matrices provide specialized microenvironments that mimic native tissues and enable stem cells to grow and differentiate into specific cell types. Here, we show that collagen three-dimensional gel matrices prepared in

Jae Ho Lee, Hye-Sun Yu, Gil-Su Lee, Aeri Ji, Jung Keun Hyun, Hae-Won Kim

Feb 6, 2013 - The theory of the clonal origin of cancer states that a tumour arises from one cell that acquires mutation(s) leading to the malignant phenotype. It is the current belief that many of these mutations give a fitness advantage to the mutant population

Arne Traulsen, Tom Lenaerts, Jorge M. Pacheco, David Dingli

Aug 12, 2011 - Skeletal muscle is a highly specialized tissue composed of non-dividing, multi-nucleated muscle fibres that contract to generate force in a controlled and directed manner. Skeletal muscle is formed during embryogenesis from a subset of muscle

Jennifer L. Shadrach, Amy J. Wagers

Jan 6, 2013 - A population of mouse embryonic stem (ES) cells is characterized by a distribution of Nanog, a gene whose expression is associated with the degree of pluripotency. Cells exhibiting high levels of Nanog maintain a state of pluripotency, while those

Yang Luo, Chea Lu Lim, Jennifer Nichols, Alfonso Martinez-Arias, Lorenz Wernisch

Aug 29, 2003 - Embryonic stem (ES) cells are permanent pluripotent stem cell lines established from pre–implantation mouse embryos. There is currently great interest in the potential therapeutic applications of analogous cells…

Mia Buehr, Austin Smith

Apr 30, 2016 - Pluripotent mouse embryonic stem cells (mESCs) show heterogeneous expression levels of transcription factors (TFs) involved in pluripotency regulation, among them Nanog and Rex1. The expression of both TFs can change dynamically between states of

Maria Herberg, Ingmar Glauche, Thomas Zerjatke, Maria Winzi, Frank Buchholz, Ingo Roeder

Aug 12, 2011 - Stem cell behaviours, such as stabilization of the undecided state of pluripotency or multipotency, the priming towards a prospective fate, binary fate decisions and irreversible commitment, must all somehow emerge from a genome-wide gene-regulatory

Sui Huang

Oct 7, 2012 - In the current study, the mechanical and hypothermic damage induced by vibration and cold storage on human mesenchymal stem cells (hMSCs) stored at 2–8°C was quantified by measuring the total cell number and cell viability after…

N. I. Nikolaev, Y. Liu, H. Hussein, D. J. Williams

Jan 6, 2010 - There is currently no suitable replacement for damaged temporomandibular joint (TMJ) discs after discectomy. In the present study, we fabricated bilayer biodegradable polylactide (PLA) discs comprising a non-woven mat of poly(L/D)lactide (P(L/D)LA)

Katja Mäenpää, Ville Ellä, Jari Mauno, Minna Kellomäki, Riitta Suuronen, Timo Ylikomi, Susanna Miettinen

Dec 6, 2010 - The use of stem cells for regenerative medicine has captured the imagination of the public, with media attention contributing to rising expectations of clinical benefits. Human embryonic stem cells (hESCs) are the best model for…

Emma Stephenson, Caroline Mackie Ogilvie, Heema Patel, Glenda Cornwell, Laureen Jacquet, Neli Kadeva, Peter Braude, Dusko Ilic