Aug 12, 2011 - Small molecules have been playing important roles in elucidating basic biology and treatment of a vast number of diseases for nearly a century, making their use in the field of stem cell biology a comparatively recent phenomenon. Nonetheless, the

Jem A. Efe, Sheng Ding

Jul 5, 2018 - Human pluripotent stem cells (PSCs) offer a scalable alternative to primary and transformed human tissue. PSCs include human embryonic stem cells, derived from the inner cell mass of blastocysts unsuitable for…

David C. Hay, Cliona O'Farrelly

How embryos build organs to last a lifetime, Croonian Lecture 2014 by Professor Brigid Hogan FRS. All the organs of our body originate from small founder populations of cells which multiply into complex structures. Adult stem cells are used to

Jan 11, 2023 - Wolbachia are the most widely distributed intracellular bacteria, and their most common effect on host phenotype is cytoplasmic incompatibility (CI). A variety of models have been proposed to decipher the molecular mechanism of CI, among which the

Weihao Dou, Baofa Sun, Yunheng Miao, Dawei Huang, Jinhua Xiao

Nov 9, 2022 - The development of organisms and tissues is dictated by an elaborate balance between cell division, apoptosis and differentiation: the cell population dynamics. To quantify these dynamics, we propose a phylodynamic inference approach based on

Sophie Seidel, Tanja Stadler