Dec 5, 2014 - Mouse epiblast stem cells (EpiSCs) display temporal differences in the upregulation of Mixl1 expression during the initial steps of in vitro differentiation, which can be correlated with their propensity for endoderm differentiation. EpiSCs that

Keren Kaufman-Francis, Hwee Ngee Goh, Yoji Kojima, Joshua B. Studdert, Vanessa Jones, Melinda D. Power, Emilie Wilkie, Erdahl Teber, David A. F. Loebel, Patrick P. L. Tam

Dec 6, 2010 - Neovascularization or new blood vessel formation is of utmost importance not only for tissue and organ development and for tissue repair and regeneration, but also for pathological processes, such as tumour development. Despite this, the endothelial

Suzanne M. Watt, Athanasios Athanassopoulos, Adrian L. Harris, Grigorios Tsaknakis

Oct 31, 2008 - KCNJ11-encoded Kir6.2 assembles with ATP-binding cassette sulphonylurea receptors to generate ATP-sensitive K+ (KATP) channel complexes. Expressed in tissues with dynamic metabolic flux, these evolutionarily conserved yet structurally and

Timothy J Nelson, Almudena Martinez-Fernandez, Andre Terzic

Oct 31, 2019 - Upon hydration and dehydration, the vegetative tissue of Selaginella lepidophylla can reversibly swell and shrink to generate complex morphological transformations. Here, we investigate how structural and compositional properties at tissue and cell

Véronique Brulé, Ahmad Rafsanjani, Meisam Asgari, Tamara L. Western, Damiano Pasini

Jan 29, 2008 - Human mesenchymal stem cells (hMSCs) isolated from bone marrow aspirates were cultured on silk scaffolds in rotating bioreactors for three weeks with either chondrogenic or osteogenic medium supplements to engineer cartilage- or bone-like tissue

Alexander Augst, Darja Marolt, Lisa E Freed, Charu Vepari, Lorenz Meinel, Michelle Farley, Robert Fajardo, Nipun Patel, Martha Gray, David L Kaplan, Gordana Vunjak-Novakovic

Mar 9, 2022 - Ageing, death, and potential immortality lie at the heart of biology, but two seemingly incompatible paradigms coexist in different research communities and have done since the nineteenth century. The universal senescence paradigm sees senescence as

A. Rupert Sheldrake

Jul 31, 2006 - Recent work in neuroscience has shown that the adult central nervous system (CNS) contains neural progenitors, precursors and stem cells that are capable of generating new neurons, astrocytes and oligodendrocytes. While challenging the previous

U Shivraj Sohur, Jason G Emsley, Bartley D Mitchell, Jeffrey D Macklis