Aug 12, 2011 - Stem cells are defined by the simultaneous possession of the seemingly incongruent properties of self-renewal and multi-lineage differentiation potential. To maintain a stem cell population, these opposing forces must be balanced.…

Rodrigo Osorno, Ian Chambers

Mar 28, 2008 - Embryonic stem cells are promising donor cell sources for cell transplantation therapy, which may in the future be used to treat various diseases and injuries. However, as is the case for organ transplantation, immune rejection…

Shinya Yamanaka

May 31, 2016 - The use of skeletal stem cells (SSCs) for cell-based therapies is currently one of the most promising areas for skeletal disease treatment and skeletal tissue repair. The ability for controlled modification of SSCs could provide significant

Catarina Costa Moura, Rahul S. Tare, Richard O. C. Oreffo, Sumeet Mahajan

Nov 25, 2019 - The mechanical performance of cardiomyocytes (CMs) is an important indicator of their maturation state and of primary importance for the development of therapies based on cardiac stem cells. As the mechanical analysis of adherent cells at

Ricardo H. Pires, Nithya Shree, Emmanuel Manu, Ewa Guzniczak, Oliver Otto

Oct 19, 2015 - The clinical trials with intrastriatal transplantation of human fetal mesencephalic tissue, rich in dopaminergic neurons, in Parkinson's disease (PD) patients show that cell replacement can work and in some cases induce major, long-lasting

Olle Lindvall

Jul 5, 2018 - Liver transplantation represents the standard treatment for people with an end-stage liver disease and some liver-based metabolic disorders; however, shortage of liver donor tissues limits its availability. Furthermore, whole liver replacement

Valeria Iansante, Anil Chandrashekran, Anil Dhawan

Oct 19, 2015 - This review addresses the progress in cartilage repair technology over the decades with an emphasis on cartilage regeneration with cell therapy. The most abundant cartilage is the hyaline cartilage that covers the surface of our joints and, due to

Anders Lindahl

Jan 5, 2016 - Hydra continuously differentiates a sophisticated nervous system made of mechanosensory cells (nematocytes) and sensory–motor and ganglionic neurons from interstitial stem cells. However, this dynamic adult neurogenesis is dispensable for

Y. Wenger, W. Buzgariu, B. Galliot