Nov 5, 2013 - During asymmetric stem cell divisions, the mitotic spindle must be correctly oriented and positioned with respect to the axis of cell polarity to ensure that cell fate determinants are appropriately segregated into only one…

Dan T. Bergstralh, Timm Haack, Daniel St Johnston

May 27, 2020 - Hutchinson–Gilford progeria syndrome (HGPS) is an ultra-rare disorder with devastating sequelae resulting in early death, presently thought to stem primarily from cardiovascular events. We analyse novel longitudinal cardiovascular data from a

S.-I. Murtada, Y. Kawamura, A. W. Caulk, H. Ahmadzadeh, N. Mikush, K. Zimmerman, D. Kavanagh, D. Weiss, M. Latorre, Z. W. Zhuang, G. S. Shadel, D. T. Braddock, J. D. Humphrey

May 6, 2014 - Recent experimental evidence suggests that acute myeloid leukaemias may originate from multiple clones of malignant cells. Nevertheless, it is not known how the observed clones may differ with respect to cell properties, such as proliferation and

Thomas Stiehl, Natalia Baran, Anthony D. Ho, Anna Marciniak-Czochra

Dr Philip Ball, winner of the 2022 Wilkins-Bernal-Medawar Medal, joins us to discuss human genome editing, and the importance of keeping historical and cultural perspectives visible in these debates. Our biotechnologies have entered uncharted

Sep 13, 2009 - A bio-chemo-mechanical model has been used to predict the contractile responses of smooth cells on a bed of micro-posts. Predictions obtained for smooth muscle cells reveal that, by converging onto a single set of parameters, the model captures all

J. P. McGarry, J. Fu, M. T. Yang, C. S. Chen, R. M. McMeeking, A. G. Evans, V. S. Deshpande

Mar 20, 2007 - Closely coupled in vitro and in virtuo models have been used to explore the self-organization of normal human keratinocytes (NHK). Although it can be observed experimentally, we lack the tools to explore many biological rules that govern NHK

Tao Sun, Phil McMinn, Simon Coakley, Mike Holcombe, Rod Smallwood, Sheila MacNeil

Jun 6, 2014 - Recent breakthroughs of cell phenotype reprogramming impose theoretical challenges on unravelling the complexity of large circuits maintaining cell phenotypes coupled at many different epigenetic and gene regulation levels, and quantitatively

Ping Wang, Chaoming Song, Hang Zhang, Zhanghan Wu, Xiao-Jun Tian, Jianhua Xing

Dec 17, 1985 - Segments in the leech arise by the proliferation of longitudinally arrayed bandlets of blast cells derived from ten identifiable embryonic stem cells, two M, two N, four O /P and two Q teloblasts. In each bandlet, older blast cells …