Nov 5, 2013 - During asymmetric stem cell divisions, the mitotic spindle must be correctly oriented and positioned with respect to the axis of cell polarity to ensure that cell fate determinants are appropriately segregated into only one…

Dan T. Bergstralh, Timm Haack, Daniel St Johnston

May 6, 2014 - Recent experimental evidence suggests that acute myeloid leukaemias may originate from multiple clones of malignant cells. Nevertheless, it is not known how the observed clones may differ with respect to cell properties, such as proliferation and

Thomas Stiehl, Natalia Baran, Anthony D. Ho, Anna Marciniak-Czochra

Oct 28, 2019 - Sea stars use adhesive secretions to attach their numerous tube feet strongly and temporarily to diverse surfaces. After detachment of the tube feet, the adhesive material stays bound to the substrate as so-called ‘footprints’. In the common sea

Birgit Lengerer, Morgane Algrain, Mathilde Lefevre, Jérôme Delroisse, Elise Hennebert, Patrick Flammang

Oct 31, 2019 - The intestine is the most anisotropically shaped organ, but, when grown in culture, embryonic intestinal stem cells form star- or sphere-shaped organoids. Here, we present evidence that spontaneous tonic and phasic contractions of the circular

Diana Khalipina, Yusuke Kaga, Nicolas Dacher, Nicolas R. Chevalier

Sep 13, 2009 - A bio-chemo-mechanical model has been used to predict the contractile responses of smooth cells on a bed of micro-posts. Predictions obtained for smooth muscle cells reveal that, by converging onto a single set of parameters, the model captures all

J. P. McGarry, J. Fu, M. T. Yang, C. S. Chen, R. M. McMeeking, A. G. Evans, V. S. Deshpande

Mar 20, 2007 - Closely coupled in vitro and in virtuo models have been used to explore the self-organization of normal human keratinocytes (NHK). Although it can be observed experimentally, we lack the tools to explore many biological rules that govern NHK

Tao Sun, Phil McMinn, Simon Coakley, Mike Holcombe, Rod Smallwood, Sheila MacNeil

Jul 10, 2019 - Hybrid male sterility (HMS) contributes to speciation by restricting gene flow between related taxa. Detailed cytological characterization of reproductive organs in hybrid males is important for identifying phenotypes that can help guide searches of

Jiangtao Liang, Igor V. Sharakhov

Jun 6, 2014 - Recent breakthroughs of cell phenotype reprogramming impose theoretical challenges on unravelling the complexity of large circuits maintaining cell phenotypes coupled at many different epigenetic and gene regulation levels, and quantitatively

Ping Wang, Chaoming Song, Hang Zhang, Zhanghan Wu, Xiao-Jun Tian, Jianhua Xing

Feb 5, 2017 - Evolving multicellularity is easy, especially in phototrophs and osmotrophs whose multicells feed like unicells. Evolving animals was much harder and unique; probably only one pathway via benthic ‘zoophytes’ with pelagic ciliated larvae allowed

Thomas Cavalier-Smith