Dec 6, 2014 - Epithelial cells undergoing epithelial-to-mesenchymal transitions have often been shown to behave as cancer stem cells, but the precise molecular connection remains elusive. At the genetic level, stemness is governed by LIN28/let-7 double inhibition

Mohit Kumar Jolly, Bin Huang, Mingyang Lu, Sendurai A. Mani, Herbert Levine, Eshel Ben-Jacob

Nov 5, 2013 - During asymmetric stem cell divisions, the mitotic spindle must be correctly oriented and positioned with respect to the axis of cell polarity to ensure that cell fate determinants are appropriately segregated into only one…

Dan T. Bergstralh, Timm Haack, Daniel St Johnston

May 6, 2014 - Recent experimental evidence suggests that acute myeloid leukaemias may originate from multiple clones of malignant cells. Nevertheless, it is not known how the observed clones may differ with respect to cell properties, such as proliferation and

Thomas Stiehl, Natalia Baran, Anthony D. Ho, Anna Marciniak-Czochra

Sep 13, 2009 - A bio-chemo-mechanical model has been used to predict the contractile responses of smooth cells on a bed of micro-posts. Predictions obtained for smooth muscle cells reveal that, by converging onto a single set of parameters, the model captures all

J. P. McGarry, J. Fu, M. T. Yang, C. S. Chen, R. M. McMeeking, A. G. Evans, V. S. Deshpande

Mar 20, 2007 - Closely coupled in vitro and in virtuo models have been used to explore the self-organization of normal human keratinocytes (NHK). Although it can be observed experimentally, we lack the tools to explore many biological rules that govern NHK

Tao Sun, Phil McMinn, Simon Coakley, Mike Holcombe, Rod Smallwood, Sheila MacNeil

Jun 6, 2014 - Recent breakthroughs of cell phenotype reprogramming impose theoretical challenges on unravelling the complexity of large circuits maintaining cell phenotypes coupled at many different epigenetic and gene regulation levels, and quantitatively

Ping Wang, Chaoming Song, Hang Zhang, Zhanghan Wu, Xiao-Jun Tian, Jianhua Xing