Aug 28, 2012 - Innovations in engineering applied to healthcare make a significant difference to people's lives. Market growth is guaranteed by demographics. Regulation and requirements for good manufacturing practice—extreme levels of repeatability and

David J. Williams, Robert J. Thomas, Paul C. Hourd, Amit Chandra, Elizabeth Ratcliffe, Yang Liu, Erin A. Rayment, J. Richard Archer

Dec 6, 2017 - Peptides are ubiquitous in nature and useful in many fields, from agriculture as pesticides, in medicine as antibacterial and antifungal drugs founded in the innate immune systems, to medicinal chemistry as hormones. However, the concept of peptides

Shuguang Zhang

Mar 5, 2018 - Telomere length (TL) in humans is highly heritable and undergoes progressive age-dependent shortening in somatic cells. By contrast, sperm donated by older men display comparatively long telomeres, presumably because in the male germline, telomeres

Abraham Aviv

Jul 5, 2018 - Drug-induced liver- and cardiotoxicity remain among the leading causes of preclinical and clinical drug attrition, marketplace drug withdrawals and black-box warnings on marketed drugs. Unfortunately, animal testing has proven to be insufficient for

Grace E. Brown, Salman R. Khetani

Apr 1, 2008 - Optical tweezers (OT) have emerged as an essential tool for manipulating single biological cells and performing sophisticated biophysical/biomechanical characterizations. Distinct advantages of using tweezers for these characterizations include

Hu Zhang, Kuo-Kang Liu

May 13, 2011 - Over the past two or three centuries, biomedical advances have provided methods to prevent and treat infectious diseases. These changes have greatly reduced human suffering and enhanced sustainability by allowing people to live longer and healthier

Ian Wilmut, Tuempong Wongtawan, Mindy Quigley, Gareth Sullivan

Aug 22, 1986 - The regulatory biology of antibody formation entered a new phase of study with the development of selective theories of immunity. The discovery of the ‘one cell - one antibody’ dogma and the demonstration that only a small minority of B cells

Aug 29, 2003 - Methods for directly turning a somatic cell type into another type (a process referred to as transdifferentiation) would be beneficial for producing replacement cells for therapeutic applications. Adult stem cells have been shown…

Philippe Collas

Nov 5, 2017 - The human blastocyst forms 5 days after one of the smallest human cells (the sperm) fertilizes one of the largest human cells (the egg). Depending on the sex-chromosome contribution from the sperm, the resulting embryo will either be female, with

Anna Sahakyan, Kathrin Plath, Claire Rougeulle