Dec 6, 2017 - Peptides are ubiquitous in nature and useful in many fields, from agriculture as pesticides, in medicine as antibacterial and antifungal drugs founded in the innate immune systems, to medicinal chemistry as hormones. However, the concept of peptides

Shuguang Zhang

Oct 6, 2011 -

Kuo-Kang Liu, Vincent Chan

Mar 6, 2013 - A very high number of different types of blood cells must be generated daily through a process called haematopoiesis in order to meet the physiological requirements of the organism. All blood cells originate from a population of relatively few

Erica Manesso, José Teles, David Bryder, Carsten Peterson

Jul 5, 2018 - Drug-induced liver- and cardiotoxicity remain among the leading causes of preclinical and clinical drug attrition, marketplace drug withdrawals and black-box warnings on marketed drugs. Unfortunately, animal testing has proven to be insufficient for

Grace E. Brown, Salman R. Khetani

Feb 7, 2012 - Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative—hollow nerve guidance conduits (NGCs)—have a number of limitations that need to be

W. Daly, L. Yao, D. Zeugolis, A. Windebank, A. Pandit

Mar 5, 2018 - Telomere length (TL) in humans is highly heritable and undergoes progressive age-dependent shortening in somatic cells. By contrast, sperm donated by older men display comparatively long telomeres, presumably because in the male germline, telomeres

Abraham Aviv

Feb 5, 2007 - The assembly of neural circuits in the vertebrate central nervous system depends on the organized generation of specific neuronal subtypes. Studies over recent years have begun to reveal the principles and elucidate some of the detailed mechanisms

James Briscoe, Bennett G Novitch

Nov 6, 2013 - Surface properties of biomaterials play a major role in the governing of cell functionalities. It is well known that mechanical, chemical and nanotopographic cues, for example, influence cell proliferation and differentiation. Here, we present a

Nadège Sachot, Oscar Castaño, Miguel A. Mateos-Timoneda, Elisabeth Engel, Josep A. Planell

Sep 27, 2019 - The unfolded protein response (UPR) is a collection of cellular feedback mechanisms that seek to maintain protein folding homeostasis in the endoplasmic reticulum (ER). When the ER is ‘stressed’, through either high protein folding demand or

Wylie Stroberg, Justin Eilertsen, Santiago Schnell

Dec 5, 2014 - In the mouse blastocyst, epiblast cells are newly formed shortly before implantation. They possess a unique developmental plasticity, termed naive pluripotency. For development to proceed, this naive state must be subsumed by multi-lineage

Tüzer Kalkan, Austin Smith