Aug 12, 2011 - Pluripotency is a transient cellular state during early development which can be recreated in vitro by direct reprogramming. The molecular mechanisms driving entry into and exit from the pluripotent state are the subject of intense research interest.

Thorold W. Theunissen, José C. R. Silva

Jun 15, 1988 - The detection of changes in mutation rate in human populations remains extremely difficult. Thus estimation of genetic hazards of mutagens to man depends on extrapolation from experimental systems. Germ cells of animals show complex variations in

Nov 28, 2005 - Understanding how the vertebrate central nervous system develops and functions is a major goal of a large body of biological research. This research is driven both by intellectual curiosity about this amazing organ that coordinates our conscious and

Katharine E Lewis

Nov 6, 2014 - The epigenetic pathway of a cell as it differentiates from a stem cell state to a mature lineage-committed one has been historically understood in terms of Waddington's landscape, consisting of hills and valleys. The smooth top and valley-strewn

Mithun K. Mitra, Paul R. Taylor, Chris J. Hutchison, T. C. B. McLeish, Buddhapriya Chakrabarti

Mar 19, 2014 - Major changes in intra- and extracellular pH homoeostasis are shared features of most solid tumours. These changes stem in large part from the metabolic shift of most cancer cells towards glycolytic metabolism and other processes associated with net

Anne Poder Andersen, José M. A. Moreira, Stine Falsig Pedersen

May 29, 2004 - Lens regeneration in urodele amphibians such as the newt proceeds from the dorsal margin of the iris where pigment epithelial cells (PEC) re–enter the cell cycle and transdifferentiate into lens. A general problem in regeneration research is to

Yutaka Imokawa, András Simon, Jeremy P. Brockes

Sep 30, 1971 - An electron microscopic study has been made of the axon terminal degeneration in the caudate nucleus in the cat after lesions in either the cerebral cortex, the thalamus, the cerebral cortex and the thalamus, the midbrain or within the caudate

Apr 6, 2010 - Bio-electrospray, the direct jet-based cell handling approach, is able to handle a wide range of cells (spanning immortalized, primary to stem cells). Studies at the genomic, genetic and the physiological levels have shown that,…

Napachanok Mongkoldhumrongkul, Suresh C. Swain, Suwan N. Jayasinghe, Stephen Stürzenbaum

Dec 29, 1999 - During the 20th century our understanding of genetics and the processes of gene expression have undergone revolutionary change. Improved technology has identified the components of the living cell, and knowledge of the genetic code allows us to

Sydney Brenner, CH FRS

Dec 7, 2012 - Severe heat-shock to bone cells caused during orthopaedic procedures can result in thermal damage, leading to cell death and initiating bone resorption. By contrast, mild heat-shock has been proposed to induce bone regeneration. In this study, bone

E. B. Dolan, M. G. Haugh, D. Tallon, C. Casey, L. M. McNamara