Jun 29, 1998 - Within the epidermis, proliferation takes place in the basal layer of keratinocytes that are attached to an underlying basement membrane. Cells that leave the basal layer undergo terminal differentiation as they move towards the tissue surface. The

Fiona M. Watt

Jan 25, 2023 - In many animals, the germline differentiates early in embryogenesis, so only mutations that accumulate in germ cells are inherited by offspring. Exceptions to this developmental process may indicate other mechanisms have evolved to limit the effects

Elora H. López-Nandam, Rebecca Albright, Erik A. Hanson, Elizabeth A. Sheets, Stephen R. Palumbi

Feb 5, 2018 - Stem cells self-renew and produce precursor cells that differentiate to become specialized cell types. Land plants generate several types of stem cells that give rise to most organs of the plant…

Rumiko Kofuji, Yasushi Yagita, Takashi Murata, Mitsuyasu Hasebe

Aug 31, 2018 - Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues and self-renew, hold great promise for both regenerative medicine and novel therapeutic discovery. However, their regenerative capacity is retained only

Hannah Donnelly, Manuel Salmeron-Sanchez, Matthew J. Dalby

Apr 6, 2013 - Haematopoietic stem cells (HSCs) are responsible for maintaining immune cells, red blood cells and platelets throughout life. HSCs must be located in their ecological niche (the bone marrow) to function correctly, that is, to…

Adam L. MacLean, Cristina Lo Celso, Michael P. H. Stumpf

Jun 6, 2018 - A challenge in regenerative medicine is governed by the need to have control over the fate of stem cells that is regulated by the physical and chemical microenvironment in vitro and in vivo. The differentiation of the stem cells…

Jekaterina Kazantseva, Irina Hussainova, Roman Ivanov, Toomas Neuman, Michael Gasik