Jun 6, 2018 - A challenge in regenerative medicine is governed by the need to have control over the fate of stem cells that is regulated by the physical and chemical microenvironment in vitro and in vivo. The differentiation of the stem cells…

Jekaterina Kazantseva, Irina Hussainova, Roman Ivanov, Toomas Neuman, Michael Gasik

Oct 6, 2011 - Stem cell therapy is an emerging technique which is being translated into treatment of degenerated tissues. However, the success of translation relies on the stem cell lineage commitment in the degenerated regions of interest. This …

Hu Zhang, Sheng Dai, Jingxiu Bi, Kuo-Kang Liu

Jul 5, 2018 - The capacity to culture stem cells in a controllable, robust and scalable manner is necessary in order to develop successful strategies for the generation of cellular and tissue platforms for drug screening, toxicity testing, tissue engineering and

Sara Schmidt, Annamaria Lilienkampf, Mark Bradley

Mar 5, 2007 - In the past 5 years, China has increased its efforts in the field of stem cell research and practice. Basic research mainly focuses on bone marrow and embryonic stem cells. Clinical applications of stem…

Lianming Liao, Lingsong Li, Robert Chunhua Zhao

Dec 20, 2011 - This paper elucidates the origins of scientific work on stem cells. From the late nineteenth century onwards, the notion of stem cells became customary in scientific communities of Imperial Germany. Adopting the term Stammzelle…

Andreas-Holger Maehle

Dec 7, 2011 - Understanding how stem cells are regulated in adult tissues is a major challenge in cell biology. In the basal layer of human epidermis, clusters of almost quiescent stem cells are interspersed with proliferating…

Allon M. Klein, Varvara Nikolaidou-Neokosmidou, David P. Doupé, Philip H. Jones, Benjamin D. Simons

Oct 19, 2015 - The appearance of stem cells coincides with the transition from single-celled organisms to metazoans. Stem cells are capable of self-renewal as well as differentiation. Each tissue is maintained by self-renewing tissue-specific…

Irving Weissman

Dec 24, 2019 - Commitment of stem cells to different lineages is inherently stochastic but regulated by a range of environmental bio/chemo/mechanical cues. Here, we develop an integrated stochastic modelling framework for predicting the differentiation of hMSCs in

H. Suresh, S. S. Shishvan, A. Vigliotti, V. S. Deshpande

Jul 5, 2018 - Effective and efficient generation of human neural stem cells and subsequently functional neural populations from pluripotent stem cells has facilitated advancements in the study of human development and disease modelling. This…

Sarah F. McComish, Maeve A. Caldwell

Feb 6, 2007 - Stem cells, although difficult to define, hold great promise as tools for understanding development and as therapeutic agents. However, as with any new field, uncritical enthusiasm can outstrip reality. In this review, we have listed nine common

Tim Magnus, Ying Liu, Graham C Parker, Mahendra S Rao