Oct 19, 2015 - Stem cells are but one class of the myriad types of cells within an organism. With potential to self-renew and capacity to differentiate, stem cells play essential roles at multiple stages of development. In the…

George Q. Daley

May 27, 2010 - This article will provide an updated review of spermatogonial stem cells and their role in maintaining the spermatogenic lineage. Experimental tools used to study spermatogonial stem cells (SSCs) will be described, along with…

Bart T. Phillips, Kathrin Gassei, Kyle E. Orwig

Jan 12, 2010 - In recent years, there has been an explosion of interest in stem cells, not just within the scientific and medical communities but also among politicians, religious groups and ethicists. Here, we summarize the different types of stem…

Fiona M. Watt, Ryan R. Driskell

May 6, 2014 - In the adult hippocampus, neurogenesis—the process of generating mature granule cells from adult neural stem cells—occurs throughout the entire lifetime. In order to investigate the involved regulatory mechanisms, knockout (KO) experiments,

Frederik Ziebell, Ana Martin-Villalba, Anna Marciniak-Czochra

Sep 30, 2016 - Despite the importance of immune cell–biomaterial interactions for the regenerative outcome, few studies have investigated how distinct three-dimensional biomaterials modulate the immune cell-mediated mesenchymal stem/stromal cells …

Hugo R. Caires, Tiago Esteves, Pedro Quelhas, Mário A. Barbosa, Melba Navarro, Catarina R. Almeida

Feb 23, 2007 - Neurogenesis persists in two germinal regions in the adult mammalian brain, the subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal formation. Within these two neurogenic niches, specialized astrocytes are

Patricio A Riquelme, Elodie Drapeau, Fiona Doetsch

Aug 31, 2017 - The capacity of bone and cartilage to regenerate can be attributed to skeletal stem cells (SSCs) that reside within the bone marrow (BM). Given SSCs are rare and lack specific surface markers, antibody-based sorting has failed to deliver the cell

Miguel Xavier, María C. de Andrés, Daniel Spencer, Richard O. C. Oreffo, Hywel Morgan

Feb 5, 2007 - The role of stem cells has long been known in reproductive organs and various tissues including the haematopoietic system and skin. During the last decade, stem cells have also been identified in other organs, including the nervous …

Jeffrey J Ross, Catherine M Verfaillie

Oct 19, 2015 - Human pluripotent stem cells can in principle be used as a source of any differentiated cell type for disease modelling, drug screening, toxicology testing or cell replacement therapy. Type I diabetes is considered a major target…

Maria Rostovskaya, Nicholas Bredenkamp, Austin Smith

May 29, 2004 - The fundamental basis of our work is that organs are generated by multipotent stem cells, whose properties we must understand to control tissue assembly or repair. Central nervous system (CNS) stem cells are now recognized as a…

R. D. McKay