Feb 6, 2007 - Stem cells, although difficult to define, hold great promise as tools for understanding development and as therapeutic agents. However, as with any new field, uncritical enthusiasm can outstrip reality. In this review, we have listed nine common

Tim Magnus, Ying Liu, Graham C Parker, Mahendra S Rao

May 27, 2010 - This article will provide an updated review of spermatogonial stem cells and their role in maintaining the spermatogenic lineage. Experimental tools used to study spermatogonial stem cells (SSCs) will be described, along with…

Bart T. Phillips, Kathrin Gassei, Kyle E. Orwig

Sep 30, 2016 - Despite the importance of immune cell–biomaterial interactions for the regenerative outcome, few studies have investigated how distinct three-dimensional biomaterials modulate the immune cell-mediated mesenchymal stem/stromal cells …

Hugo R. Caires, Tiago Esteves, Pedro Quelhas, Mário A. Barbosa, Melba Navarro, Catarina R. Almeida

Jan 12, 2010 - In recent years, there has been an explosion of interest in stem cells, not just within the scientific and medical communities but also among politicians, religious groups and ethicists. Here, we summarize the different types of stem…

Fiona M. Watt, Ryan R. Driskell

May 6, 2014 - In the adult hippocampus, neurogenesis—the process of generating mature granule cells from adult neural stem cells—occurs throughout the entire lifetime. In order to investigate the involved regulatory mechanisms, knockout (KO) experiments,

Frederik Ziebell, Ana Martin-Villalba, Anna Marciniak-Czochra

Aug 31, 2017 - The capacity of bone and cartilage to regenerate can be attributed to skeletal stem cells (SSCs) that reside within the bone marrow (BM). Given SSCs are rare and lack specific surface markers, antibody-based sorting has failed to deliver the cell

Miguel Xavier, María C. de Andrés, Daniel Spencer, Richard O. C. Oreffo, Hywel Morgan

Oct 19, 2015 - Human pluripotent stem cells can in principle be used as a source of any differentiated cell type for disease modelling, drug screening, toxicology testing or cell replacement therapy. Type I diabetes is considered a major target…

Maria Rostovskaya, Nicholas Bredenkamp, Austin Smith

Feb 23, 2007 - Neurogenesis persists in two germinal regions in the adult mammalian brain, the subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal formation. Within these two neurogenic niches, specialized astrocytes are

Patricio A Riquelme, Elodie Drapeau, Fiona Doetsch

Feb 5, 2007 - The role of stem cells has long been known in reproductive organs and various tissues including the haematopoietic system and skin. During the last decade, stem cells have also been identified in other organs, including the nervous …

Jeffrey J Ross, Catherine M Verfaillie

Jul 5, 2018 - In recent years, protocols have been established to differentiate stem and precursor cells into more mature cell types. However, progress in this field has been hampered by difficulties to assess the differentiation status of stem…

Patricio Godoy, Wolfgang Schmidt-Heck, Birte Hellwig, Patrick Nell, David Feuerborn, Jörg Rahnenführer, Kathrin Kattler, Jörn Walter, Nils Blüthgen, Jan G. Hengstler