May 29, 2004 - The fundamental basis of our work is that organs are generated by multipotent stem cells, whose properties we must understand to control tissue assembly or repair. Central nervous system (CNS) stem cells are now recognized as a…

R. D. McKay

Mar 28, 2008 - Haematopoietic stem cells (HSCs) can supply all blood cells throughout the adult life of individuals. Based on this property, HSCs have been used for bone marrow and cord blood transplantation. Among various stem…

Hideo Ema, Hiromitsu Nakauchi

Nov 21, 2006 - We present an optical imaging system and mathematical algorithms for three-dimensional sensing and identification of stem cells. Data acquisition of stem cells is based on holographic microscopy in the Fresnel domain by…

Inkyu Moon, Bahram Javidi

Jun 6, 2018 - There is urgent need to improve the clinical outcome of peripheral nerve injury. Many efforts are directed towards the fabrication of bioengineered conduits, which could deliver stem cells to the site of injury to promote and guide peripheral nerve

Andrea Francesco Verre, Alessandro Faroni, Maria Iliut, Claudio Silva, Cristopher Muryn, Adam J. Reid, Aravind Vijayaraghavan

Jun 29, 1998 - The mammalian intestinal mucosa, with its distinctive polarity, high rate of proliferation and rapid cell migration, is an excellent model system to study proliferative hierarchies and the regulation of cell division, differentiation and cell death.

Christopher S. Potten

Jul 5, 2018 - Bone has many functions. It is responsible for protecting the underlying soft organs, it allows locomotion, houses the bone marrow and stores minerals such as calcium and phosphate. Upon damage, bone tissue can efficiently repair itself. However,

Wai Long Tam, Frank P. Luyten, Scott J. Roberts

Jul 5, 2018 - Over the past few decades, a variety of different reagents for stem cell maintenance and differentiation have been commercialized. These reagents share a common goal in facilitating the manufacture of products suitable for cell therapy while

Louise Hagbard, Katherine Cameron, Paul August, Christopher Penton, Malin Parmar, David C. Hay, Therése Kallur

Jan 12, 2011 - Adult stem cells maintain the mature tissues of metazoans. They do so by reproducing in such a way that their progeny either differentiate, and thus contribute functionally to a tissue, or remain uncommitted and replenish the stem…

Gregory W. Charville, Thomas A. Rando

Aug 12, 2011 - Stem cells with the potential to form many different cell types are actively studied for their possible use in cell replacement therapies for several diseases. In addition, the differentiated derivatives of stem…

D. A. Melton

Apr 29, 2002 - The recent derivation of human embryonic stem (ES) cell lines, together with results suggesting an unexpected degree of plasticity in later, seemingly more restricted, stem cells (so–called adult stem…

Peter W. Andrews