Oct 26, 2022 - The maintenance and regeneration of adult tissues rely on the self-renewal of stem cells. Regeneration without over-proliferation requires precise regulation of the stem cell proliferation and differentiation rates. The nature of…

Rodrigo García-Tejera, Linus Schumacher, Ramon Grima

Feb 19, 2007 - Conceptual and technical advances in neural stem cell biology are being applied to the study of human brain tumours. These studies suggest that human brain tumours are organized as a hierarchy and are maintained by a small number of tumour cells

Peter B Dirks

Jan 25, 2023 - In many animals, the germline differentiates early in embryogenesis, so only mutations that accumulate in germ cells are inherited by offspring. Exceptions to this developmental process may indicate other mechanisms have evolved to limit the effects

Elora H. López-Nandam, Rebecca Albright, Erik A. Hanson, Elizabeth A. Sheets, Stephen R. Palumbi

Jan 5, 2013 - Somatic cell nuclear transfer (SCNT) cloning is the sole reproductive engineering technology that endows the somatic cell genome with totipotency. Since the first report on the birth of a cloned sheep from adult somatic cells in…

Atsuo Ogura, Kimiko Inoue, Teruhiko Wakayama

Jun 29, 1998 - Within the epidermis, proliferation takes place in the basal layer of keratinocytes that are attached to an underlying basement membrane. Cells that leave the basal layer undergo terminal differentiation as they move towards the tissue surface. The

Fiona M. Watt

Recent developments in genetic technologies have accelerated us towards a new era of medicine. Personalised medicine is quickly moving from the realm of science fiction to everyday healthcare, whilst scientific ability to alter human genetics is

Aug 31, 2018 - Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues and self-renew, hold great promise for both regenerative medicine and novel therapeutic discovery. However, their regenerative capacity is retained only

Hannah Donnelly, Manuel Salmeron-Sanchez, Matthew J. Dalby