Jun 21, 2007 - Although recent progress in cardiovascular tissue engineering has generated great expectations for the exploitation of stem cells to restore cardiac form and function, the prospects of a common mass-produced cell resource for clinically viable

Puspa Batten, Nadia A Rosenthal, Magdi H Yacoub

Jan 5, 2013 - In recent times, the epigenetic study of pluripotency based on cellular reprogramming techniques led to the creation of induced pluripotent stem cells. It has come to represent the forefront of a new wave of alternative therapeutic approaches in the

Huan-Ting Lin, Makoto Otsu, Hiromitsu Nakauchi

Aug 7, 2012 - Metabolomics is a method for investigation of changes in the global metabolite profile of cells. This paper discusses the technical application of the approach, considering metabolite extraction, separation, mass spectrometry and data interpretation.

Laura E. McNamara, Terje Sjöström, R. M. Dominic Meek, Richard O. C. Oreffo, Bo Su, Matthew J. Dalby, Karl E. V. Burgess

Feb 5, 2007 - All the neurons and glial cells of the central nervous system are generated from the neuroepithelial cells in the walls of the embryonic neural tube, the ‘embryonic neural stem cells’. The stem…

Nicoletta Kessaris, Nigel Pringle, William D Richardson

Nov 6, 2014 - It is very important to understand the onset and growth pattern of breast primary tumours as well as their metastatic dissemination. In most cases, it is the metastatic disease that ultimately kills the patient. There is increasing evidence that

Kerri-Ann Norton, Aleksander S. Popel

Dec 23, 2020 - A recent hypothesis proposed that the total number of stem cell divisions in a tissue (TSCD model) determine its intrinsic cancer risk; however, a different model—the multistage model—has long been used to understand how cancer originates.

Leonard Nunney, Kevin Thai

Mar 13, 2008 - Recent advances in stem cell research, including the selective expansion of neural stem cells (NSCs) in vitro, the induction of particular neural cells from embryonic stem cells in …

Hideyuki Okano, Kazunobu Sawamoto