Feb 5, 2018 - Stem cells self-renew and produce precursor cells that differentiate to become specialized cell types. Land plants generate several types of stem cells that give rise to most organs of the plant…

Rumiko Kofuji, Yasushi Yagita, Takashi Murata, Mitsuyasu Hasebe

Jul 5, 2018 - Stem cell technology in regenerative medicine has the potential to provide an unlimited supply of cells for drug testing, medical transplantation and academic research. In order to engineer a realistic tissue model using stem…

Gregor Skeldon, Baltasar Lucendo-Villarin, Wenmiao Shu

Jun 6, 2018 - A challenge in regenerative medicine is governed by the need to have control over the fate of stem cells that is regulated by the physical and chemical microenvironment in vitro and in vivo. The differentiation of the stem cells…

Jekaterina Kazantseva, Irina Hussainova, Roman Ivanov, Toomas Neuman, Michael Gasik

Apr 6, 2013 - Haematopoietic stem cells (HSCs) are responsible for maintaining immune cells, red blood cells and platelets throughout life. HSCs must be located in their ecological niche (the bone marrow) to function correctly, that is, to…

Adam L. MacLean, Cristina Lo Celso, Michael P. H. Stumpf

Jul 5, 2018 - The capacity to culture stem cells in a controllable, robust and scalable manner is necessary in order to develop successful strategies for the generation of cellular and tissue platforms for drug screening, toxicity testing, tissue engineering and

Sara Schmidt, Annamaria Lilienkampf, Mark Bradley

Dec 24, 2019 - Commitment of stem cells to different lineages is inherently stochastic but regulated by a range of environmental bio/chemo/mechanical cues. Here, we develop an integrated stochastic modelling framework for predicting the differentiation of hMSCs in

H. Suresh, S. S. Shishvan, A. Vigliotti, V. S. Deshpande

Jul 5, 2018 - Effective and efficient generation of human neural stem cells and subsequently functional neural populations from pluripotent stem cells has facilitated advancements in the study of human development and disease modelling. This…

Sarah F. McComish, Maeve A. Caldwell

Oct 19, 2015 - The appearance of stem cells coincides with the transition from single-celled organisms to metazoans. Stem cells are capable of self-renewal as well as differentiation. Each tissue is maintained by self-renewing tissue-specific…

Irving Weissman