Jun 21, 2007 - Although recent progress in cardiovascular tissue engineering has generated great expectations for the exploitation of stem cells to restore cardiac form and function, the prospects of a common mass-produced cell resource for clinically viable

Puspa Batten, Nadia A Rosenthal, Magdi H Yacoub

Jan 5, 2013 - In recent times, the epigenetic study of pluripotency based on cellular reprogramming techniques led to the creation of induced pluripotent stem cells. It has come to represent the forefront of a new wave of alternative therapeutic approaches in the

Huan-Ting Lin, Makoto Otsu, Hiromitsu Nakauchi

Dec 23, 2020 - A recent hypothesis proposed that the total number of stem cell divisions in a tissue (TSCD model) determine its intrinsic cancer risk; however, a different model—the multistage model—has long been used to understand how cancer originates.

Leonard Nunney, Kevin Thai

Oct 19, 2015 - Growing old is our destiny. However, the mature differentiated cells making up our body can be rejuvenated to an embryo-like fate called pluripotency which is an ability to differentiate into all cell types by enforced expression of defined

Mari Ohnuki, Kazutoshi Takahashi

Aug 7, 2012 - Metabolomics is a method for investigation of changes in the global metabolite profile of cells. This paper discusses the technical application of the approach, considering metabolite extraction, separation, mass spectrometry and data interpretation.

Laura E. McNamara, Terje Sjöström, R. M. Dominic Meek, Richard O. C. Oreffo, Bo Su, Matthew J. Dalby, Karl E. V. Burgess

Feb 5, 2007 - All the neurons and glial cells of the central nervous system are generated from the neuroepithelial cells in the walls of the embryonic neural tube, the ‘embryonic neural stem cells’. The stem…

Nicoletta Kessaris, Nigel Pringle, William D Richardson

Oct 31, 2016 - During embryogenesis, the spherical inner cell mass (ICM) proliferates in the confined environment of a blastocyst. Embryonic stem cells (ESCs) are derived from the ICM, and mimicking embryogenesis in vitro, mouse ESCs (mESCs) are often cultured in

Sebastian V. Hadjiantoniou, David Sean, Maxime Ignacio, Michel Godin, Gary W. Slater, Andrew E. Pelling