Oct 19, 2015 - Since the first publication of the derivation of human embryonic stem cells in 1998, there has been hope and expectation that this technology will lead to a wave of regenerative medicine therapies with the potential to revolutionize our approach to

Paul Whiting, Julie Kerby, Peter Coffey, Lyndon da Cruz, Ruth McKernan

Nov 6, 2014 - It is very important to understand the onset and growth pattern of breast primary tumours as well as their metastatic dissemination. In most cases, it is the metastatic disease that ultimately kills the patient. There is increasing evidence that

Kerri-Ann Norton, Aleksander S. Popel

Aug 12, 2011 - Research into the pathophysiological mechanisms of human disease and the development of targeted therapies have been hindered by a lack of predictive disease models that can be experimentally manipulated in vitro. This review describes the current

Juli J. Unternaehrer, George Q. Daley

Mar 13, 2008 - Recent advances in stem cell research, including the selective expansion of neural stem cells (NSCs) in vitro, the induction of particular neural cells from embryonic stem cells in …

Hideyuki Okano, Kazunobu Sawamoto

Dec 6, 2018 - The metaphor of a potential epigenetic differentiation landscape broadly suggests that during differentiation a stem cell approaches a stable equilibrium state from a higher free energy towards a stable equilibrium state which represents the final

K. Wiesner, J. Teles, M. Hartnor, C. Peterson

Jul 5, 2018 - Pluripotent stem cells (PSCs) lie at the heart of modern regenerative medicine due to their properties of unlimited self-renewal in vitro and their ability to differentiate into cell types representative of the three embryonic germ layers—mesoderm,

R. Abu-Dawud, N. Graffmann, S. Ferber, W. Wruck, J. Adjaye

Jun 29, 2004 - The potential use of pluripotent stem cells for tissue repair or replacement is now well recognized. While the ability of embryonic stem (ES) cells to differentiate into all cells of the body is undisputed, their…

Patricia Murray, David Edgar

Aug 12, 2011 - Recent advances in stem cell technology have generated enthusiasm for their potential to study and treat a diverse range of human disease. Pluripotent human stem cells for therapeutic use may, in principle, be obtained from two…

Craig J. Taylor, Eleanor M. Bolton, J. Andrew Bradley

Dec 5, 2014 - To date, many regulatory genes and signalling events coordinating mammalian development from blastocyst to gastrulation stages have been identified by mutational analyses and reverse-genetic approaches, typically on a gene-by-gene basis. More recent

David-Emlyn Parfitt, Michael M. Shen