Oct 6, 2011 - Stem cell therapy is an emerging technique which is being translated into treatment of degenerated tissues. However, the success of translation relies on the stem cell lineage commitment in the degenerated regions of interest. This …

Hu Zhang, Sheng Dai, Jingxiu Bi, Kuo-Kang Liu

Mar 5, 2007 - In the past 5 years, China has increased its efforts in the field of stem cell research and practice. Basic research mainly focuses on bone marrow and embryonic stem cells. Clinical applications of stem…

Lianming Liao, Lingsong Li, Robert Chunhua Zhao

Oct 19, 2015 - Stem cells are but one class of the myriad types of cells within an organism. With potential to self-renew and capacity to differentiate, stem cells play essential roles at multiple stages of development. In the…

George Q. Daley

Dec 20, 2011 - This paper elucidates the origins of scientific work on stem cells. From the late nineteenth century onwards, the notion of stem cells became customary in scientific communities of Imperial Germany. Adopting the term Stammzelle…

Andreas-Holger Maehle

Dec 7, 2011 - Understanding how stem cells are regulated in adult tissues is a major challenge in cell biology. In the basal layer of human epidermis, clusters of almost quiescent stem cells are interspersed with proliferating…

Allon M. Klein, Varvara Nikolaidou-Neokosmidou, David P. Doupé, Philip H. Jones, Benjamin D. Simons

Feb 6, 2007 - Stem cells, although difficult to define, hold great promise as tools for understanding development and as therapeutic agents. However, as with any new field, uncritical enthusiasm can outstrip reality. In this review, we have listed nine common

Tim Magnus, Ying Liu, Graham C Parker, Mahendra S Rao

Sep 30, 2016 - Despite the importance of immune cell–biomaterial interactions for the regenerative outcome, few studies have investigated how distinct three-dimensional biomaterials modulate the immune cell-mediated mesenchymal stem/stromal cells …

Hugo R. Caires, Tiago Esteves, Pedro Quelhas, Mário A. Barbosa, Melba Navarro, Catarina R. Almeida

Aug 31, 2017 - The capacity of bone and cartilage to regenerate can be attributed to skeletal stem cells (SSCs) that reside within the bone marrow (BM). Given SSCs are rare and lack specific surface markers, antibody-based sorting has failed to deliver the cell

Miguel Xavier, María C. de Andrés, Daniel Spencer, Richard O. C. Oreffo, Hywel Morgan

Jul 5, 2018 - In recent years, protocols have been established to differentiate stem and precursor cells into more mature cell types. However, progress in this field has been hampered by difficulties to assess the differentiation status of stem…

Patricio Godoy, Wolfgang Schmidt-Heck, Birte Hellwig, Patrick Nell, David Feuerborn, Jörg Rahnenführer, Kathrin Kattler, Jörn Walter, Nils Blüthgen, Jan G. Hengstler