Feb 6, 2014 - Multi-potent adult mesenchymal stem cells (MSCs) derived from bone marrow have therapeutic potential for bone diseases and regenerative medicine. However, an intrinsic heterogeneity in their phenotype, which in turn results in various

Rebecca Medda, Arne Helth, Patrick Herre, Darius Pohl, Bernd Rellinghaus, Nadine Perschmann, Stefanie Neubauer, Horst Kessler, Steffen Oswald, Jürgen Eckert, Joachim P. Spatz, Annett Gebert, Elisabetta A. Cavalcanti-Adam

Apr 6, 2014 - The regulation of cell growth in animal tissues is a question of critical importance: most tissues contain different types of cells in interconversion and the fraction of each type has to be controlled in a precise way, by mechanisms that remain

E. Hannezo, J. Prost, J.-F. Joanny

Jul 5, 2018 - Stem cell-derived hepatocyte-like cells (HLCs) offer great opportunities for studies of host–pathogen interactions and tissue regeneration, as well as hepatotoxicity. To reliably predict the outcome of infection or to enhance graft survival, a

Lena Fischer, David C. Hay, Cliona O'Farrelly

Mar 28, 2008 - Neural stem cells (NSCs) possess the ability to self-renew and to differentiate along neuronal and glial lineages. These processes are defined by the dynamic interplay between extracellular cues including cytokine signalling and intracellular

Masakazu Namihira, Jun Kohyama, Masahiko Abematsu, Kinichi Nakashima

Jul 6, 2015 - Three-dimensional imaging of human stem cells using transmission soft X-ray tomography (SXT) is presented for the first time. Major organelle types—nuclei, nucleoli, mitochondria, lysosomes and vesicles—were discriminated at approximately 50 nm

J. C. Niclis, S. V. Murphy, D. Y. Parkinson, A. Zedan, A. H. Sathananthan, D. S. Cram, P. Heraud

Feb 28, 2017 - Spheroids formed of mesenchymal stem cells (MSCs) exhibit increased cell survival and trophic factor secretion compared with dissociated MSCs, making them therapeutically advantageous for cell therapy. Presently, there is no…

Kaitlin C. Murphy, Ben P. Hung, Stephen Browne-Bourne, Dejie Zhou, Jessica Yeung, Damian C. Genetos, J. Kent Leach

Jun 29, 1998 - The efficiency of liver regeneration in response to the loss of hepatocytes is widely acknowledged, and this is usually accomplished by the triggering of normally proliferatively quiescent hepatocytes into the cell cycle. However, when regeneration

Malcolm Alison, Matthew Golding, El–Nasir Lalani, Catherine Sarraf

Aug 12, 2011 - Induced pluripotent stem (iPS) cells have considerable promise as a novel tool for modelling human disease and for drug discovery. While the generation of disease-specific iPS cells has become routine, realizing the potential of iPS…

Gabsang Lee, Lorenz Studer

Aug 12, 2011 - Somatic cells have been reprogrammed into pluripotent stem cells by introducing a combination of several transcription factors, such as Oct3/4, Sox2, Klf4 and c-Myc. Induced pluripotent stem (iPS) cells from a…

Keisuke Okita, Shinya Yamanaka