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Nobel Prizes go to Royal Society Fellows

The Royal Society is a Fellowship of the world's most eminent scientists and is the oldest scientific academy in continuous existence. We aim to expand the frontiers of knowledge by championing the development and use of science, mathematics,

Journal - Journal of The Royal Society Interface

Genomic expression of mesenchymal stem cells to altered nanoscale topographies

Feb 12, 2008 - The understanding of cellular response to the shape of their environment would be of benefit in the development of artificial extracellular environments for potential use in the production of biomimetic surfaces. Specifically, the understanding of

Journal - Proceedings of the Royal Society B: Biological Sciences

Evolutionary origins of germline segregation in Metazoa: evidence for a germ stem cell lineage in the coral Orbicella…

Jan 13, 2016 - The ability to segregate a committed germ stem cell (GSC) lineage distinct from somatic cell lineages is a characteristic of bilaterian Metazoans. However, the occurrence of GSC lineage specification in basally branching Metazoan phyla, such as

Journal - Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences

Genome manipulation in embryonic stem cells

Feb 27, 1993 - Embryonic stem (ES) cells derived from pluripotent cells of the early mouse embryo provide a powerful tool for genome manipulation in mammals. Dominantly acting effects can be achieved by introducing constructs to misexpress or ectopically express a

Journal - Journal of The Royal Society Interface

Systems level approach reveals the correlation of endoderm differentiation of mouse embryonic stem cells with specific…

Jun 6, 2014 - Stem cells receive numerous cues from their associated substrate that help to govern their behaviour. However, identification of influential substrate characteristics poses difficulties because of their complex nature. In this study, we developed an

Journal - Journal of The Royal Society Interface

Characterization of the interface between adsorbed fibronectin and human embryonic stem cells

Jun 6, 2013 - The cell–substrate interface plays a key role in the regulation of cell behaviour. Defining the properties of this interface is particularly important for human embryonic stem (hES) cell culture, because changes in this environment …

Journal - Journal of The Royal Society Interface

Mesenchymal stem cell mechanobiology and emerging experimental platforms

Jul 6, 2013 - Experimental control over progenitor cell lineage specification can be achieved by modulating properties of the cell's microenvironment. These include physical properties of the cell adhesion substrate, such as rigidity, topography and deformation