Aug 12, 2011 - Somatic cells have been reprogrammed into pluripotent stem cells by introducing a combination of several transcription factors, such as Oct3/4, Sox2, Klf4 and c-Myc. Induced pluripotent stem (iPS) cells from a…

Keisuke Okita, Shinya Yamanaka

Feb 12, 2008 - The understanding of cellular response to the shape of their environment would be of benefit in the development of artificial extracellular environments for potential use in the production of biomimetic surfaces. Specifically, the understanding of

Matthew J Dalby, Abhay Andar, Abhijit Nag, Stanley Affrossman, Rahul Tare, Sara McFarlane, Richard O.C Oreffo

Mar 19, 2018 - Solid progress has occurred over the last decade in our understanding of the molecular genetic basis of neurodevelopmental disorders, and of schizophrenia and autism in particular. Although the genetic architecture of both disorders is far more

David St. Clair, Mandy Johnstone

Feb 27, 1993 - Embryonic stem (ES) cells derived from pluripotent cells of the early mouse embryo provide a powerful tool for genome manipulation in mammals. Dominantly acting effects can be achieved by introducing constructs to misexpress or ectopically express a

Jun 6, 2014 - Stem cells receive numerous cues from their associated substrate that help to govern their behaviour. However, identification of influential substrate characteristics poses difficulties because of their complex nature. In this study, we developed an

Keith Task, Antonio D'Amore, Satish Singh, Joe Candiello, Maria Jaramillo, William R. Wagner, Prashant Kumta, Ipsita Banerjee

Jun 6, 2013 - The cell–substrate interface plays a key role in the regulation of cell behaviour. Defining the properties of this interface is particularly important for human embryonic stem (hES) cell culture, because changes in this environment …

Deepak M. Kalaskar, Joan E. Downes, Patricia Murray, David H. Edgar, Rachel L. Williams

Mar 12, 1990 - Haemopoietic stem cells in vivo proliferate and develop in association with stromal cells of the bone marrow. Proliferation and differentiation of haemopoietic stem cells also occurs in vitro, either in association …

Jul 6, 2013 - Experimental control over progenitor cell lineage specification can be achieved by modulating properties of the cell's microenvironment. These include physical properties of the cell adhesion substrate, such as rigidity, topography and deformation

Luke MacQueen, Yu Sun, Craig A. Simmons

Aug 5, 2016 - In the central nervous system (CNS), during both brain and spinal cord development, purinergic and pyrimidinergic signalling molecules (ATP, UTP and adenosine) act synergistically with peptidic growth factors in regulating the synchronized

Davide Lecca, Marta Fumagalli, Stefania Ceruti, Maria P. Abbracchio