Jul 5, 2018 - Pluripotent stem cells (PSCs) lie at the heart of modern regenerative medicine due to their properties of unlimited self-renewal in vitro and their ability to differentiate into cell types representative of the three embryonic germ layers—mesoderm,

R. Abu-Dawud, N. Graffmann, S. Ferber, W. Wruck, J. Adjaye

Aug 12, 2011 - Stem cells with the potential to form many different cell types are actively studied for their possible use in cell replacement therapies for several diseases. In addition, the differentiated derivatives of stem…

D. A. Melton

Oct 31, 2016 - During embryogenesis, the spherical inner cell mass (ICM) proliferates in the confined environment of a blastocyst. Embryonic stem cells (ESCs) are derived from the ICM, and mimicking embryogenesis in vitro, mouse ESCs (mESCs) are often cultured in

Sebastian V. Hadjiantoniou, David Sean, Maxime Ignacio, Michel Godin, Gary W. Slater, Andrew E. Pelling

Oct 19, 2015 - Growing old is our destiny. However, the mature differentiated cells making up our body can be rejuvenated to an embryo-like fate called pluripotency which is an ability to differentiate into all cell types by enforced expression of defined

Mari Ohnuki, Kazutoshi Takahashi

Oct 19, 2015 - Since the first publication of the derivation of human embryonic stem cells in 1998, there has been hope and expectation that this technology will lead to a wave of regenerative medicine therapies with the potential to revolutionize our approach to

Paul Whiting, Julie Kerby, Peter Coffey, Lyndon da Cruz, Ruth McKernan

Apr 29, 2002 - The recent derivation of human embryonic stem (ES) cell lines, together with results suggesting an unexpected degree of plasticity in later, seemingly more restricted, stem cells (so–called adult stem…

Peter W. Andrews

Jun 21, 2007 - Although recent progress in cardiovascular tissue engineering has generated great expectations for the exploitation of stem cells to restore cardiac form and function, the prospects of a common mass-produced cell resource for clinically viable

Puspa Batten, Nadia A Rosenthal, Magdi H Yacoub

Jan 5, 2013 - In recent times, the epigenetic study of pluripotency based on cellular reprogramming techniques led to the creation of induced pluripotent stem cells. It has come to represent the forefront of a new wave of alternative therapeutic approaches in the

Huan-Ting Lin, Makoto Otsu, Hiromitsu Nakauchi

Aug 6, 2019 - An excessive foreign body response (FBR) has contributed to the adverse events associated with polypropylene mesh usage for augmenting pelvic organ prolapse surgery. Consequently, current biomaterial research considers the critical role of the FBR

Shayanti Mukherjee, Saeedeh Darzi, Kallyanashis Paul, Jerome A. Werkmeister, Caroline E. Gargett

Aug 7, 2012 - Metabolomics is a method for investigation of changes in the global metabolite profile of cells. This paper discusses the technical application of the approach, considering metabolite extraction, separation, mass spectrometry and data interpretation.

Laura E. McNamara, Terje Sjöström, R. M. Dominic Meek, Richard O. C. Oreffo, Bo Su, Matthew J. Dalby, Karl E. V. Burgess