Feb 12, 2008 - The understanding of cellular response to the shape of their environment would be of benefit in the development of artificial extracellular environments for potential use in the production of biomimetic surfaces. Specifically, the understanding of

Matthew J Dalby, Abhay Andar, Abhijit Nag, Stanley Affrossman, Rahul Tare, Sara McFarlane, Richard O.C Oreffo

Feb 27, 1993 - Embryonic stem (ES) cells derived from pluripotent cells of the early mouse embryo provide a powerful tool for genome manipulation in mammals. Dominantly acting effects can be achieved by introducing constructs to misexpress or ectopically express a

Jun 6, 2014 - Stem cells receive numerous cues from their associated substrate that help to govern their behaviour. However, identification of influential substrate characteristics poses difficulties because of their complex nature. In this study, we developed an

Keith Task, Antonio D'Amore, Satish Singh, Joe Candiello, Maria Jaramillo, William R. Wagner, Prashant Kumta, Ipsita Banerjee

Jun 6, 2013 - The cell–substrate interface plays a key role in the regulation of cell behaviour. Defining the properties of this interface is particularly important for human embryonic stem (hES) cell culture, because changes in this environment …

Deepak M. Kalaskar, Joan E. Downes, Patricia Murray, David H. Edgar, Rachel L. Williams

Mar 12, 1990 - Haemopoietic stem cells in vivo proliferate and develop in association with stromal cells of the bone marrow. Proliferation and differentiation of haemopoietic stem cells also occurs in vitro, either in association …

Jul 6, 2013 - Experimental control over progenitor cell lineage specification can be achieved by modulating properties of the cell's microenvironment. These include physical properties of the cell adhesion substrate, such as rigidity, topography and deformation

Luke MacQueen, Yu Sun, Craig A. Simmons

Mar 6, 2015 - The study of mesenchymal stem cell (MSC) migration under flow conditions with investigation of the underlying molecular mechanism could lead to a better understanding and outcome in stem-cell-based cell therapy and …

Brandon D. Riehl, Jeong Soon Lee, Ligyeom Ha, Jung Yul Lim