Aug 16, 2005 - Immune self-tolerance is controlled by a subset of T lymphocytes that are regulatory (Treg) and epigenetically programmed to suppress auto-reactive immune effector cells in vivo. By extrapolation, donor-specific transplantation tolerance might be

Su M Metcalfe

Nov 5, 2017 - X-chromosome inactivation (XCI) is an exemplar of epigenetic regulation that is set up as pluripotent cells differentiate. Once established, XCI is stably propagated, but can be reversed in vivo or by pluripotent reprogramming in vitro. Although

Irene Cantone, Amanda G. Fisher

Apr 29, 2020 - Micro-computed tomography (micro-CT) provides a means to analyse and model three-dimensional (3D) tissue engineering scaffolds. This study proposes a set of micro-CT-based tools firstly for evaluating the microstructure of scaffolds and secondly for

Aleksi Palmroth, Sanna Pitkänen, Markus Hannula, Kaarlo Paakinaho, Jari Hyttinen, Susanna Miettinen, Minna Kellomäki

Aug 29, 2003 - During the development of multicellular organisms, the processes of growth and differentiation are kept in balance to generate and maintain tissues and organs of the correct size, shape and cellular composition. We have investigated the molecular

Sarah L. Crittenden, Christian R. Eckmann, Liaoteng Wang, David S. Bernstein, Marvin Wickens, Judith Kimble

Sep 14, 2020 - Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer with a short median survival time. GBM is characterized by the hallmarks of aggressive proliferation and cellular infiltration of normal brain tissue. miR-451 and its

Yangjin Kim, Donggu Lee, Sean Lawler

Aug 12, 2011 - Reprogramming differentiated cells towards pluripotency can be achieved by different experimental strategies including the forced expression of specific ‘inducers’ and nuclear transfer. While these offer unparalleled opportunities to generate

Francesco M. Piccolo, Carlos F. Pereira, Irene Cantone, Karen Brown, Tomomi Tsubouchi, Jorge Soza-Ried, Matthias Merkenschlager, Amanda G. Fisher

Jun 28, 2019 - We have developed a novel electro-osmotic microfluidic system to apply precisely controlled osmolarity gradients to cancer cells in micro-channels. We observed that albeit adhesion is not required for cells to migrate in such a confined

T. H. Hui, W. C. Cho, H. W. Fong, M. Yu, K. W. Kwan, K. C. Ngan, K. H. Wong, Y. Tan, S. Yao, H. Jiang, Z. Gu, Y. Lin