Aug 12, 2011 - Small molecules have been playing important roles in elucidating basic biology and treatment of a vast number of diseases for nearly a century, making their use in the field of stem cell biology a comparatively recent phenomenon. Nonetheless, the

Jem A. Efe, Sheng Ding

Apr 6, 2020 - As the field of tissue engineering continues to advance rapidly, so too does the complexity of cell culture techniques used to generate in vitro tissue constructs, with the overall aim of mimicking the in vivo microenvironment. This complexity

H. W. Hoyle, L. A. Smith, R. J. Williams, S. A. Przyborski

Jun 28, 2019 - Low-intensity electric fields can induce changes in cell differentiation and cytoskeletal stresses that facilitate manipulation of osteoblasts and mesenchymal stem cells; however, the application times (tens of minutes) are of the order of

Ram Anand Vadlamani, Yaohui Nie, David A. Detwiler, Agni Dhanabal, Alan M. Kraft, Shihuan Kuang, Timothy P. Gavin, Allen L. Garner

Mar 30, 2020 - Thousands of unfixed transposable element (TE) insertions segregate in the human population, but little is known about their impact on genome function. Recently, a few studies associated unfixed TE insertions to mRNA levels of adjacent genes, but

Clément Goubert, Nicolas Arce Zevallos, Cédric Feschotte

Jul 5, 2018 - Recent advances in the isolation of tissue-resident adult stem cells and the identification of inductive factors that efficiently direct differentiation of human pluripotent stem cells along specific lineages have facilitated the…

Sharmin Alhaque, Michael Themis, Hassan Rashidi

Nov 5, 2017 - Already during early embryogenesis, before sex-specific hormone production is initiated, sex differences in embryonic development have been observed in several mammalian species. Typically, female embryos develop more slowly than their male siblings.

Edda G. Schulz

Nov 25, 2019 - The mechanical performance of cardiomyocytes (CMs) is an important indicator of their maturation state and of primary importance for the development of therapies based on cardiac stem cells. As the mechanical analysis of adherent cells at

Ricardo H. Pires, Nithya Shree, Emmanuel Manu, Ewa Guzniczak, Oliver Otto