Jul 5, 2018 - Gastrointestinal diseases are becoming increasingly prevalent in developed countries. Immortalized cells and animal models have delivered important but limited insight into the mechanisms that initiate and propagate these diseases. Human-specific

Kathryn L. Fair, Jennifer Colquhoun, Nicholas R. F. Hannan

Aug 31, 2018 - The cellular age distribution of hierarchically organized tissues can reveal important insights into the dynamics of cell differentiation and self-renewal and associated cancer risks. Here, we examine the effect of progenitor compartments with

Marvin A. Böttcher, David Dingli, Benjamin Werner, Arne Traulsen

Nov 5, 2017 - X-chromosome inactivation (XCI) is an exemplar of epigenetic regulation that is set up as pluripotent cells differentiate. Once established, XCI is stably propagated, but can be reversed in vivo or by pluripotent reprogramming in vitro. Although

Irene Cantone, Amanda G. Fisher

Aug 29, 2003 - During the development of multicellular organisms, the processes of growth and differentiation are kept in balance to generate and maintain tissues and organs of the correct size, shape and cellular composition. We have investigated the molecular

Sarah L. Crittenden, Christian R. Eckmann, Liaoteng Wang, David S. Bernstein, Marvin Wickens, Judith Kimble

Apr 29, 2020 - Micro-computed tomography (micro-CT) provides a means to analyse and model three-dimensional (3D) tissue engineering scaffolds. This study proposes a set of micro-CT-based tools firstly for evaluating the microstructure of scaffolds and secondly for

Aleksi Palmroth, Sanna Pitkänen, Markus Hannula, Kaarlo Paakinaho, Jari Hyttinen, Susanna Miettinen, Minna Kellomäki

Aug 12, 2011 - Reprogramming differentiated cells towards pluripotency can be achieved by different experimental strategies including the forced expression of specific ‘inducers’ and nuclear transfer. While these offer unparalleled opportunities to generate

Francesco M. Piccolo, Carlos F. Pereira, Irene Cantone, Karen Brown, Tomomi Tsubouchi, Jorge Soza-Ried, Matthias Merkenschlager, Amanda G. Fisher