Aug 21, 1987 - The development of a cell-culture system for the cloning and clonal differentiation of different types of blood cell has made it possible to identify: (i), the proteins that regulate growth and differentiation of different cell…

Dec 6, 2013 - Cellular differentiation, reprogramming and transdifferentiation are determined by underlying gene regulatory networks. Non-adiabatic regulation via slow binding/unbinding to the gene can be important in these cell fate decision-making processes.

Chunhe Li, Jin Wang

Aug 12, 2011 - There has been an immense interest in embryonic stem cells owing to their pluripotent property, which refers to the ability to differentiate into all cell types of an embryo. In the maintenance of this pluripotent nature, transcription factors play

Kun Xue, Jia-Hui Ng, Huck-Hui Ng

Oct 12, 2020 - Retinoic acid (RA), derived from vitamin A, is a major teratogen, clinically recognized in 1983. Identification of its natural presence in the embryo and dissection of its molecular mechanism of action became possible in the animal model with the

Ségolène Bernheim, Sigolène M. Meilhac

Jul 5, 2018 - Gastrointestinal diseases are becoming increasingly prevalent in developed countries. Immortalized cells and animal models have delivered important but limited insight into the mechanisms that initiate and propagate these diseases. Human-specific

Kathryn L. Fair, Jennifer Colquhoun, Nicholas R. F. Hannan

Aug 31, 2018 - The cellular age distribution of hierarchically organized tissues can reveal important insights into the dynamics of cell differentiation and self-renewal and associated cancer risks. Here, we examine the effect of progenitor compartments with

Marvin A. Böttcher, David Dingli, Benjamin Werner, Arne Traulsen