May 28, 2018 - Mechanical signals are ubiquitous in our everyday life and the process of converting these mechanical signals into a biological signalling response is known as mechanotransduction. Our understanding of mechanotransduction, and its contribution to

Shaun N. Robertson, Paul Campsie, Peter G. Childs, Fiona Madsen, Hannah Donnelly, Fiona L. Henriquez, William G. Mackay, Manuel Salmerón-Sánchez, Monica P. Tsimbouri, Craig Williams, Matthew J. Dalby, Stuart Reid

Nov 25, 2019 - Understanding the origins of animal multicellularity is a fundamental biological question. Recent genome data have unravelled the role that co-option of pre-existing genes played in the origin of animals. However, there were also some important

David López-Escardó, Xavier Grau-Bové, Amy Guillaumet-Adkins, Marta Gut, Michael E. Sieracki, Iñaki Ruiz-Trillo

Aug 21, 1987 - The development of a cell-culture system for the cloning and clonal differentiation of different types of blood cell has made it possible to identify: (i), the proteins that regulate growth and differentiation of different cell…

Dec 6, 2013 - Cellular differentiation, reprogramming and transdifferentiation are determined by underlying gene regulatory networks. Non-adiabatic regulation via slow binding/unbinding to the gene can be important in these cell fate decision-making processes.

Chunhe Li, Jin Wang

Aug 12, 2011 - There has been an immense interest in embryonic stem cells owing to their pluripotent property, which refers to the ability to differentiate into all cell types of an embryo. In the maintenance of this pluripotent nature, transcription factors play

Kun Xue, Jia-Hui Ng, Huck-Hui Ng

Oct 12, 2020 - Retinoic acid (RA), derived from vitamin A, is a major teratogen, clinically recognized in 1983. Identification of its natural presence in the embryo and dissection of its molecular mechanism of action became possible in the animal model with the

Ségolène Bernheim, Sigolène M. Meilhac

Aug 16, 2005 - Immune self-tolerance is controlled by a subset of T lymphocytes that are regulatory (Treg) and epigenetically programmed to suppress auto-reactive immune effector cells in vivo. By extrapolation, donor-specific transplantation tolerance might be

Su M Metcalfe