May 31, 2016 - The use of skeletal stem cells (SSCs) for cell-based therapies is currently one of the most promising areas for skeletal disease treatment and skeletal tissue repair. The ability for controlled modification of SSCs could provide significant

Catarina Costa Moura, Rahul S. Tare, Richard O. C. Oreffo, Sumeet Mahajan

Jul 5, 2018 - Liver transplantation represents the standard treatment for people with an end-stage liver disease and some liver-based metabolic disorders; however, shortage of liver donor tissues limits its availability. Furthermore, whole liver replacement

Valeria Iansante, Anil Chandrashekran, Anil Dhawan

Feb 5, 2015 - Anchorage-dependent cells are of great interest for various biotechnological applications. (i) They represent a formidable production means of viruses for vaccination purposes at very large scales (in 1000–6000 l reactors) using microcarriers, and

Otto-Wilhelm Merten

May 28, 2018 - Mechanical signals are ubiquitous in our everyday life and the process of converting these mechanical signals into a biological signalling response is known as mechanotransduction. Our understanding of mechanotransduction, and its contribution to

Shaun N. Robertson, Paul Campsie, Peter G. Childs, Fiona Madsen, Hannah Donnelly, Fiona L. Henriquez, William G. Mackay, Manuel Salmerón-Sánchez, Monica P. Tsimbouri, Craig Williams, Matthew J. Dalby, Stuart Reid

Oct 19, 2015 - The clinical trials with intrastriatal transplantation of human fetal mesencephalic tissue, rich in dopaminergic neurons, in Parkinson's disease (PD) patients show that cell replacement can work and in some cases induce major, long-lasting

Olle Lindvall

Jan 5, 2016 - Hydra continuously differentiates a sophisticated nervous system made of mechanosensory cells (nematocytes) and sensory–motor and ganglionic neurons from interstitial stem cells. However, this dynamic adult neurogenesis is dispensable for

Y. Wenger, W. Buzgariu, B. Galliot

Oct 19, 2015 - This review addresses the progress in cartilage repair technology over the decades with an emphasis on cartilage regeneration with cell therapy. The most abundant cartilage is the hyaline cartilage that covers the surface of our joints and, due to

Anders Lindahl

Nov 25, 2019 - Understanding the origins of animal multicellularity is a fundamental biological question. Recent genome data have unravelled the role that co-option of pre-existing genes played in the origin of animals. However, there were also some important

David López-Escardó, Xavier Grau-Bové, Amy Guillaumet-Adkins, Marta Gut, Michael E. Sieracki, Iñaki Ruiz-Trillo

Aug 12, 2011 - Stem cells are defined by the simultaneous possession of the seemingly incongruent properties of self-renewal and multi-lineage differentiation potential. To maintain a stem cell population, these opposing forces must be balanced.…

Rodrigo Osorno, Ian Chambers

Mar 28, 2008 - Embryonic stem cells are promising donor cell sources for cell transplantation therapy, which may in the future be used to treat various diseases and injuries. However, as is the case for organ transplantation, immune rejection…

Shinya Yamanaka