Oct 12, 2020 - Retinoic acid (RA), derived from vitamin A, is a major teratogen, clinically recognized in 1983. Identification of its natural presence in the embryo and dissection of its molecular mechanism of action became possible in the animal model with the

Ségolène Bernheim, Sigolène M. Meilhac

Jul 5, 2018 - Gastrointestinal diseases are becoming increasingly prevalent in developed countries. Immortalized cells and animal models have delivered important but limited insight into the mechanisms that initiate and propagate these diseases. Human-specific

Kathryn L. Fair, Jennifer Colquhoun, Nicholas R. F. Hannan

Aug 31, 2018 - The cellular age distribution of hierarchically organized tissues can reveal important insights into the dynamics of cell differentiation and self-renewal and associated cancer risks. Here, we examine the effect of progenitor compartments with

Marvin A. Böttcher, David Dingli, Benjamin Werner, Arne Traulsen

Apr 29, 2020 - Micro-computed tomography (micro-CT) provides a means to analyse and model three-dimensional (3D) tissue engineering scaffolds. This study proposes a set of micro-CT-based tools firstly for evaluating the microstructure of scaffolds and secondly for

Aleksi Palmroth, Sanna Pitkänen, Markus Hannula, Kaarlo Paakinaho, Jari Hyttinen, Susanna Miettinen, Minna Kellomäki

Nov 5, 2017 - X-chromosome inactivation (XCI) is an exemplar of epigenetic regulation that is set up as pluripotent cells differentiate. Once established, XCI is stably propagated, but can be reversed in vivo or by pluripotent reprogramming in vitro. Although

Irene Cantone, Amanda G. Fisher

Aug 21, 1987 - The development of a cell-culture system for the cloning and clonal differentiation of different types of blood cell has made it possible to identify: (i), the proteins that regulate growth and differentiation of different cell…

Sep 14, 2020 - Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer with a short median survival time. GBM is characterized by the hallmarks of aggressive proliferation and cellular infiltration of normal brain tissue. miR-451 and its

Yangjin Kim, Donggu Lee, Sean Lawler