Jul 19, 2015 - Peto's paradox is the lack of the expected trend in cancer incidence as a function of body size and lifespan across species. The leading hypothesis to explain this pattern is natural selection for differential cancer prevention in larger, longer

Robert Noble, Oliver Kaltz, Michael E. Hochberg

Aug 29, 2003 - During the development of multicellular organisms, the processes of growth and differentiation are kept in balance to generate and maintain tissues and organs of the correct size, shape and cellular composition. We have investigated the molecular

Sarah L. Crittenden, Christian R. Eckmann, Liaoteng Wang, David S. Bernstein, Marvin Wickens, Judith Kimble

Sep 14, 2020 - Collective migration, the movement of groups in which individuals affect the behaviour of one another, occurs at practically every scale, from bacteria up to whole species' populations. Universal principles of collective movement can be applied at

Adam Shellard, Roberto Mayor

Jul 26, 2019 - Cancer develops from mutated cells in normal tissues. Whether somatic mutations alter normal cell dynamics is key to understanding cancer risk and guiding interventions to reduce it. An analysis of the first incomplete moment of size distributions

Michael W. J. Hall, Philip H. Jones, Benjamin A. Hall

Mar 29, 2021 - In nervous systems, there are two main modes of transmission for the propagation of activity between cells. Synaptic transmission relies on close contact at chemical or electrical synapses while volume transmission is mediated by diffusible chemical

Gáspár Jékely

Aug 12, 2011 - Reprogramming differentiated cells towards pluripotency can be achieved by different experimental strategies including the forced expression of specific ‘inducers’ and nuclear transfer. While these offer unparalleled opportunities to generate

Francesco M. Piccolo, Carlos F. Pereira, Irene Cantone, Karen Brown, Tomomi Tsubouchi, Jorge Soza-Ried, Matthias Merkenschlager, Amanda G. Fisher

Aug 31, 2018 - The intestinal epithelium is a single layer of cells which provides the first line of defence of the intestinal mucosa to bacterial infection. Cohesion of this physical barrier is supported by renewal of epithelial stem cells, residing in

Daniele Muraro, Aimee Parker, Laura Vaux, Sarah Filippi, Axel A. Almet, Alexander G. Fletcher, Alastair J. M. Watson, Carmen Pin, Philip K. Maini, Helen M. Byrne

Feb 20, 2007 - The anticipated therapeutic uses of neural stem cells depend on their ability to retain a certain level of developmental plasticity. In particular, cells must respond to developmental manipulations designed to specify precise neural fates. Studies

Nicholas D Allen