Feb 5, 2015 - Cadherins are mediators of cell–cell adhesion in epithelial tissues. E-cadherin is a known tumour suppressor and plays a central role in suppressing the invasive phenotype of cancer cells. However, the abnormal expression of N- and P-cadherin

Richard T. Bryan

Jun 1, 2021 - Anne Warner applied physiological techniques to developmental biology, elucidating the mechanisms of cell interaction and communication that pattern the early embryo. Through her determination and passion for science, she contributed crucial

Sarah Guthrie

Feb 7, 2012 - An exacerbated inflammatory response questions biomaterial biocompatibility, but on the other hand, inflammation has a central role in the regulation of tissue regeneration. Therefore, it may be argued that an ‘ideal’ inflammatory response is

Catarina R. Almeida, Daniela P. Vasconcelos, Raquel M. Gonçalves, Mário A. Barbosa

Apr 30, 2017 - In this review, we discuss recent developments in the field of nanoparticles and their use in tissue regeneration approaches. Owing to their unique chemical properties and flexibility in design, nanoparticles can be used as drug delivery systems, to

Sabine van Rijt, Pamela Habibovic

Jan 5, 2016 - Eukaryotic cells convert external stimuli into membrane depolarization, which in turn triggers effector responses such as secretion and contraction. Here, we put forward an evolutionary hypothesis for the origin of the

Thibaut Brunet, Detlev Arendt

Aug 19, 2016 - Differentiation within multicellular organisms is controlled by epigenetic markers transmitted across cell division. The process of differentiation will modify these epigenetic markers so that information that one cell type possesses can be lost in

Michael Lachmann, Eric Libby

Apr 24, 2019 - Arm loss through a separation at a specialized autotomy plane in echinoderms is inextricably linked to regeneration, but the link between these phenomena is poorly explored. We investigated nervous system regeneration post-autotomy in the asteriid

Maria Byrne, Franca Mazzone, Maurice R. Elphick, Michael C. Thorndyke, Paula Cisternas

Jun 29, 1998 - The main pathways of epithelial differentiation in the intestine, Paneth, mucous, endocrine and columnar cell lineages are well recognized. However, in abnormal circumstances, for example in mucosal ulceration, a cell lineage with features distinct

Nicholas A. Wright