Jul 31, 2006 - Diseases of the brain and spinal cord represent especially daunting challenges for cell-based strategies of repair, given the multiplicity of cell types within the adult central nervous system, and the precision with which they must interact in both

Steven A Goldman, Martha S Windrem

Oct 5, 2017 - Nucleosome remodelling (NR) regulates transcription in an ATP-dependent manner, and influences gene expression required for development and cellular functions, including those involved in anti-cancer and anti-ageing processes. ATP-utilizing

Reiko Watanabe, Shin-ichiro Kanno, Amaneh Mohammadi Roushandeh, Ayako Ui, Akira Yasui

Jul 6, 2014 - Urological reconstructive surgery is sometimes hampered by a lack of tissue. In some cases, autologous urothelial cells (UCs) are not available for cell expansion and ordinary tissue engineering. In these cases, we wanted to explore whether

J. Zhao, S. Zeiai, Å. Ekblad, A. Nordenskjöld, J. Hilborn, C. Götherström, M. Fossum

Jul 5, 2018 - A large body of data have accumulated that characterize the gene regulatory network of stem cells. Yet, a comprehensive and integrative understanding of this complex network is lacking. Network reverse engineering methods that use transcriptome data

Johannes Meisig, Nils Blüthgen

Oct 12, 2020 - Advances in fluorescence microscopy approaches have made it relatively easy to generate multi-dimensional image volumes and have highlighted the need for flexible image analysis tools for the extraction of quantitative information from such data.

Karolis Leonavicius, Christophe Royer, Antonio M. A. Miranda, Richard C. V. Tyser, Annemarie Kip, Shankar Srinivas

Aug 6, 2020 - Animal tissue requires low-oxygen conditions for its maintenance. The need for low-oxygen conditions contrasts with the idea of an evolutionary leap in animal diversity as a result of expanding oxic conditions. To accommodate tissue renewal at oxic

Emma U. Hammarlund

Oct 19, 2015 - The predominant view of embryonic development and cell differentiation has been that rigid and even irreversible epigenetic marks are laid down along the path of cell specialization ensuring the proper silencing of unrelated lineage programmes. This

Koji Tanabe, Daniel Haag, Marius Wernig

Nov 7, 2012 - The cell walls in plants are made up of just four basic building blocks: cellulose (the main structural fibre of the plant kingdom) hemicellulose, lignin and pectin. Although the microstructure of plant cell walls varies in different types of plants,

Lorna J. Gibson