Jan 5, 2016 - Eukaryotic cells convert external stimuli into membrane depolarization, which in turn triggers effector responses such as secretion and contraction. Here, we put forward an evolutionary hypothesis for the origin of the

Thibaut Brunet, Detlev Arendt

Aug 19, 2016 - Differentiation within multicellular organisms is controlled by epigenetic markers transmitted across cell division. The process of differentiation will modify these epigenetic markers so that information that one cell type possesses can be lost in

Michael Lachmann, Eric Libby

Dec 5, 2014 - Embryonic stem (ES) cells are characterized by their functional potency and capacity to self-renew in culture. Historically, ES cells have been defined as pluripotent, able to make the embryonic but not the extraembryonic lineages (such as the yolk

Sophie M. Morgani, Joshua M. Brickman

Jan 7, 2012 - World Health Organization estimated that heart failure initiated by coronary artery disease and myocardial infarction (MI) leads to 29 per cent of deaths worldwide. Heart failure is one of the leading causes of death in industrialized countries and

Jayarama Reddy Venugopal, Molamma P. Prabhakaran, Shayanti Mukherjee, Rajeswari Ravichandran, Kai Dan, Seeram Ramakrishna

Feb 5, 2015 - Cadherins are mediators of cell–cell adhesion in epithelial tissues. E-cadherin is a known tumour suppressor and plays a central role in suppressing the invasive phenotype of cancer cells. However, the abnormal expression of N- and P-cadherin

Richard T. Bryan

Mar 12, 1990 - As part of our attempts to understand principles that underly organism development, we have been studying the development of the rat optic nerve. This simple tissue is composed of three glial cell types derived from two distinct cellular lineages.

Jun 29, 2002 - Arabidopsis leaf hairs (trichomes) are polyploid epidermal cells with a predictable branching pattern. More than 15 genes have been identified that are involved in the regulation of branching. The cloning of the ZWICHEL, ANGUSTIFOLIA and STICHEL

A. Schnittger, M. Hülskamp

Jan 5, 2018 - During metastasis, tumour cells must communicate with their microenvironment by secreted soluble factors and extracellular vesicles. Different stromal cell types (e.g. bone marrow–derived cells, endothelial cells and fibroblasts)…

Lucía Robado de Lope, Olwen Leaman Alcíbar, Ana Amor López, Marta Hergueta-Redondo, Héctor Peinado

Feb 7, 2012 - An exacerbated inflammatory response questions biomaterial biocompatibility, but on the other hand, inflammation has a central role in the regulation of tissue regeneration. Therefore, it may be argued that an ‘ideal’ inflammatory response is

Catarina R. Almeida, Daniela P. Vasconcelos, Raquel M. Gonçalves, Mário A. Barbosa