Aug 12, 2011 - Modern stem cell biology has achieved a transformation that was thought by many to be every bit as unattainable as the ancient alchemists' dream of transforming base metals into gold. Exciting opportunities arise from the process known as

Ian Wilmut, Gareth Sullivan, Ian Chambers

Dec 4, 1984 - We have used differential cDNA cloning techniques to isolate a number of genes that are activated as a result of transformation by the DNA tumour virus Simian virus 40. From the nucleotide sequences of the cDNA clones we have been able to identify

Jan 12, 2011 - Telomeres protect the chromosome ends from unscheduled DNA repair and degradation. Telomeres are heterochromatic domains composed of repetitive DNA (TTAGGG repeats) bound to an array of specialized proteins. The length of telomere repeats and the

Luis E. Donate, Maria A. Blasco

Jul 5, 2018 - Hepatic stress and injury from drugs continues to be a major concern within the pharmaceutical industry, leading to preclinical and clinical attrition precautionary warnings and post-market withdrawal of drugs. There is a requirement for more

Dominic P. Williams

Mar 6, 2013 - A very high number of different types of blood cells must be generated daily through a process called haematopoiesis in order to meet the physiological requirements of the organism. All blood cells originate from a population of relatively few

Erica Manesso, José Teles, David Bryder, Carsten Peterson

Feb 7, 2012 - Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative—hollow nerve guidance conduits (NGCs)—have a number of limitations that need to be

W. Daly, L. Yao, D. Zeugolis, A. Windebank, A. Pandit

Oct 6, 2011 -

Kuo-Kang Liu, Vincent Chan

Feb 5, 2007 - The assembly of neural circuits in the vertebrate central nervous system depends on the organized generation of specific neuronal subtypes. Studies over recent years have begun to reveal the principles and elucidate some of the detailed mechanisms

James Briscoe, Bennett G Novitch