Nov 6, 2013 - Surface properties of biomaterials play a major role in the governing of cell functionalities. It is well known that mechanical, chemical and nanotopographic cues, for example, influence cell proliferation and differentiation. Here, we present a

Nadège Sachot, Oscar Castaño, Miguel A. Mateos-Timoneda, Elisabeth Engel, Josep A. Planell

May 19, 2017 - The shoot apical meristem (SAM) is a small population of stem cells that continuously generates organs and tissues. We will discuss here flower formation at the SAM, which involves a complex network of regulatory genes and signalling molecules. A

Ursula Abad, Massimiliano Sassi, Jan Traas

Feb 27, 1993 - Gene therapy is defined as the delivery of a functional gene for expression in somatic tissues with the intent to cure a disease. Different gene transfer strategies may be required to target different tissues. Adenosine deaminase (ADA) deficiency is

Dec 5, 2014 - In the mouse blastocyst, epiblast cells are newly formed shortly before implantation. They possess a unique developmental plasticity, termed naive pluripotency. For development to proceed, this naive state must be subsumed by multi-lineage

Tüzer Kalkan, Austin Smith

Dec 29, 2002 - We review results on the in vivo properties of neurons in the dorsal lateral geniculate nucleus (dLGN) that receives its afferent input from the retina and projects to the visual cortex. In addition, the dLGN receives input from the brain stem and

Florentin Wörgötter, Dirk Eyding, Jeffrey D. Macklis, Klaus Funke

Jul 5, 2018 - We describe the production of a human induced pluripotent stem cell (iPSC) line, SFCi55-ZsGr, that has been engineered to express the fluorescent reporter gene, ZsGreen, in a constitutive manner. The CAG-driven ZsGreen expression cassette was

Martha Lopez-Yrigoyen, Antonella Fidanza, Luca Cassetta, Richard A. Axton, A. Helen Taylor, Jose Meseguer-Ripolles, Anestis Tsakiridis, Valerie Wilson, David C. Hay, Jeffrey W. Pollard, Lesley M. Forrester

Jul 19, 2016 - Genome sequencing studies of de novo mutations in humans have revealed surprising incongruities in our understanding of human germline mutation. In particular, the mutation rate observed in modern humans is substantially lower than that estimated

Aylwyn Scally

Mar 5, 2018 - The integrity of chromosome ends, or telomeres, depends on myriad processes that must balance the need to compact and protect the telomeric, G-rich DNA from detection as a double-stranded DNA break, and yet still permit access to enzymes that process

Lea Harrington, Fabio Pucci