Jul 5, 2018 - We describe the production of a human induced pluripotent stem cell (iPSC) line, SFCi55-ZsGr, that has been engineered to express the fluorescent reporter gene, ZsGreen, in a constitutive manner. The CAG-driven ZsGreen expression cassette was

Martha Lopez-Yrigoyen, Antonella Fidanza, Luca Cassetta, Richard A. Axton, A. Helen Taylor, Jose Meseguer-Ripolles, Anestis Tsakiridis, Valerie Wilson, David C. Hay, Jeffrey W. Pollard, Lesley M. Forrester

Feb 5, 2007 - The assembly of neural circuits in the vertebrate central nervous system depends on the organized generation of specific neuronal subtypes. Studies over recent years have begun to reveal the principles and elucidate some of the detailed mechanisms

James Briscoe, Bennett G Novitch

Jul 19, 2016 - Genome sequencing studies of de novo mutations in humans have revealed surprising incongruities in our understanding of human germline mutation. In particular, the mutation rate observed in modern humans is substantially lower than that estimated

Aylwyn Scally

Mar 5, 2018 - The integrity of chromosome ends, or telomeres, depends on myriad processes that must balance the need to compact and protect the telomeric, G-rich DNA from detection as a double-stranded DNA break, and yet still permit access to enzymes that process

Lea Harrington, Fabio Pucci

Nov 6, 2013 - Surface properties of biomaterials play a major role in the governing of cell functionalities. It is well known that mechanical, chemical and nanotopographic cues, for example, influence cell proliferation and differentiation. Here, we present a

Nadège Sachot, Oscar Castaño, Miguel A. Mateos-Timoneda, Elisabeth Engel, Josep A. Planell

Oct 6, 2015 - Sap transport in trees has long fascinated scientists, and a vast literature exists on experimental and modelling studies of trees during the growing season when large negative stem pressures are generated by transpiration from leaves. Much less

Isabell Graf, Maurizio Ceseri, John M. Stockie

Feb 27, 1993 - Gene therapy is defined as the delivery of a functional gene for expression in somatic tissues with the intent to cure a disease. Different gene transfer strategies may be required to target different tissues. Adenosine deaminase (ADA) deficiency is

Dec 5, 2014 - In the mouse blastocyst, epiblast cells are newly formed shortly before implantation. They possess a unique developmental plasticity, termed naive pluripotency. For development to proceed, this naive state must be subsumed by multi-lineage

Tüzer Kalkan, Austin Smith